Hase, Koji

J-GLOBAL         Last updated: Oct 20, 2019 at 02:42
 
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Name
Hase, Koji
URL
http://square.umin.ac.jp/keio-dbc/
Affiliation
Keio University
Section
Faculty of Pharmacy Department of Pharmaceutical Sciences
Job title
Professor

Research Areas

 
 

Awards & Honors

 
Nov 2016
宿主-腸内細菌叢相互作用, 第53回ベルツ賞(2等賞), べーリンガーインゲルハイム
 
Feb 2016
粘膜面における免疫制御機構の解明, 第12回日本学術振興会賞
 

Published Papers

 
Nagai M., Noguchi R., Takahashi D., Morikawa T., Koshida K., Komiyama S., Ishihara N., Yamada T., Kawamura Y., Muroi K., Hattori K., Kobayashi N., Fujimura Y., Hirota M., Matsumoto R., Aoki R., Tamura-Nakano M., Sugiyama M., Katakai T., Sato S., Takubo K., Dohi T., Hase K.
Cell   178(5) 1072-1087.e14   Aug 2019
© 2019 Elsevier Inc. Nutritional status potentially influences immune responses; however, how nutritional signals regulate cellular dynamics and functionality remains obscure. Herein, we report that temporary fasting drastically reduces the number...
Nishida K., Hasegawa A., Yamasaki S., Uchida R., Ohashi W., Kurashima Y., Kunisawa J., Kimura S., Iwanaga T., Watarai H., Hase K., Ogura H., Nakayama M., Kashiwakura J., Okayama Y., Kubo M., Ohara O., Kiyono H., Koseki H., Murakami M., Hirano T.
Sci. Rep.   9(1) 10842   Jul 2019   [Refereed]
The Author(s). Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role of the released Zn is c...
Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, and *HASE Koji
J. Exp. Med.   216(4) 831-846   Apr 2019   [Refereed]
Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell d...
Kimura S., Mutoh M., Hisamoto M., Saito H., Takahashi S., Asakura T., Ishii M., Nakamura Y., Iida J., Hase K., Iwanaga T.
Frontiers in Immunology   10(JUN)    2019
© 2019 Kimura, Mutoh, Hisamoto, Saito, Takahashi, Asakura, Ishii, Nakamura, Iida, Hase and Iwanaga. Microfold (M) cells residing in the follicle-associated epithelium of mucosa-associated lymphoid tissues are specialized for sampling luminal antig...
Ohashi W., Hara T., Takagishi T., Hase K., Fukada T.
Digestive Diseases and Sciences      2019
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has reveal...

Misc

 
腸内エコロジーを支える生物間代謝経路
山田恭央, 長谷 耕二
実験医学   36(18) 3964-3069   Nov 2018
腸内エコロジーの破綻と炎症性腸疾患
長谷 耕二
実験医学   36(18) 3054-3058   Nov 2018
M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance.
Nakamura Y, Kimura S, HASE K.
Inflamm Regen.   38 15   Sep 2018   [Refereed][Invited]
粘膜免疫組織としての小腸
長谷 耕二
消化器病サイエンス   2(3)    Sep 2018   [Invited]
粘膜面におけるバリア機能と免疫恒常性の維持に果たすM細胞の役割
石原成美, 小林伸英, 長谷 耕二
アレルギー   67(3) 171-187   May 2018   [Invited]

Books etc

 
ヒトマイクロバイオーム研究最前線
長谷 耕二 (Part:Contributor, 腸内細菌定着と宿主エピゲノム変化)
(株)エヌ・ティー・エス   Mar 2016   ISBN:978-4-86043-449-6
エピジェネティクスキーワード事典
長谷 耕二, 古澤之裕, 尾畑佑樹 (Part:Joint Work, 自己免疫・アレルギー疾患とエピジェネティクス)
羊土社   Dec 2013   
臨床粘膜免疫学
長谷 耕二 (Part:Joint Work, 粘膜上皮細胞における抗原捕捉と提示)
(株)シナジー   Dec 2010   

Conference Activities & Talks

 
飢餓ストレスによるリンパ球の動態制御 [Invited]
HASE Koji
2017年度生命科学系学会合同年次大会 (ConBio2017)   7 Dec 2017   
腸内細菌由来の酪酸による全身性自己免応答の制御
HASE Koji
第22回日本食物繊維学会   25 Nov 2017   
マイクロバイオータとアレルギー [Invited]
HASE Koji
第54回小児アレルギー学会   17 Nov 2017   
Intestinal microbiota-derived metabolites regulate autoimmunity through epigenetic modifications [Invited]
HASE Koji
Fujihara Seminar   13 Sep 2017   
Microbiota-derived metabolites shape host immunity [Invited]
HASE Koji
第59回歯科基礎医学会学術大会   8 Sep 2017   

Teaching Experience

 

Research Grants & Projects

 
多変量解析による慢性炎症スパイラル形成機構の解明
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Jul 2017 - Mar 2020    Investigator(s): 長谷 耕二
Elucidation of T-independent IgA class switch machinery
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): 長谷 耕二
生物間代謝経路によって制御される脂質クオリティの解析
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2018    Investigator(s): 長谷 耕二
Single cell analysis of T lymphocytes in the intestinal immune system
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2018    Investigator(s): 長谷 耕二