Takeshi Taketani

J-GLOBAL         Last updated: Jan 9, 2019 at 15:38
Takeshi Taketani
Shimane University
Faculty of Medicine
Job title
Associate Professor
Novel NUP98-HOXC11 fusion gene resulted from a chromosonal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15:q13)(Shimane Medical University (Japan))
Research funding number

Research Areas



Faculty of Medicine, Shimane Medical University

Published Papers

Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases
Bo R, Yamada K, Kobayashi H, Jamiyan P, Hasegawa Y, Taketani T, Fukuda S, Hata I, Niida Y, Shigematsu Y, Iijima K, Yamaguchi S
Clin Pediatr Endocrinol   62(9) 809-814   Sep 2017   [Refereed]
Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway
Li Y, Ohira M, Zhou Y, Xiong T, Luo W, Yang C, Li X, Gao Z, Zhou R, Nakamura Y, Kamijo T, Kaneko Y, Taketani T, Ueyama J, Tajiri T, Zhang H, Wang J, Yang H, Yin Y, Nakagawara A
J Hum Genet   8(34) 56684-56697   May 2017   [Refereed]
A newborn case with carnitine palmitoyltransferase II deficiency initially judged as unaffected by acylcarnitine analysis soon after birth
Yamada K, Bo R, Kobayashi H, Hasegawa Y, Ago M, Fukuda S, Yamaguchi S, Taketani T
Oncotarget   11 59-61   May 2017   [Refereed]
Single nucleotide polymorphisms of the DGKB and VCAM1 genes are associated with granulocyte colony stimulating factor-mediated peripheral blood stem cell mobilization
Mishima S, Matsuda C, Ishihara T, Nagase M, Taketani T, Nagai A
Mol Genet Metab Rep   56(2) 154-159   Apr 2017   [Refereed]
Efficacy of bezafibrate on fibroblasts of glutaric acidemia type II patients evaluated using an in vitro probe acylcarnitine assay
Yamada K, Kobayashi H, Bo R, Purevsuren J, Mushimoto Y, Takahashi T, Hasegawa Y, Taketani T, Fukuda S, Yamaguchi S
Transfus Apher Sci   39(1) 48-57   Jan 2017   [Refereed]
A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy
Wada K, Kobayashi H, Moriyama A, Haneda Y, Mushimoto Y, Hasegawa Y, Onigata K, Kumori K, Ishikawa N, Maruyama R, Sogo T, Murphy L, Taketani T
26(4) 251-257   2017   [Refereed]
Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells
Abe M, Pelus LM, Singh P, Hirade T, Onishi C, Purevsuren J, Taketani T, Yamaguchi S, Fukuda S
Brain Dev   11(7)    Jul 2016   [Refereed]
Fatal pulmonary arterial hypertension in an infant girl with incontinentia pigmenti
Yasuda K, Minami N, Yoshikawa Y, Taketani T, Fukuda S, Yamaguchi S
PLoS One   58(5) 394-396   May 2016   [Refereed]
Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases
Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S
Pediatr Int   38(3) 293-301   Mar 2016   [Refereed]
Pediatric granulomatous orchitis: Case report and review of the literature
Matsumura M, Taketani T, Horie A, Mizota Y, Nakata S, Kumori K, Nagase M, Harada Y, Tanaka Y, Yamaguchi S
Brain Dev   58(2) 155-158   Feb 2016   [Refereed]
Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells
Hirade T, Abe M, Onishi C, Taketani T, Yamaguchi S, Fukuda S
Pediatr Int   103(1) 95-106   Jan 2016   [Refereed]
A fetus with mitochondrial trifunctional protein deficiency: Elevation of
Bo R, Hasegawa Y, Yamada K, Kobayashi H, Taketani T, Fukuda S, Yamaguchi S
Int J Hematol   6 1-4   Dec 2015   [Refereed]
Ex Vivo Expanded Allogeneic Mesenchymal Stem Cells With Bone Marrow Transplantation Improved Osteogenesis in Infants With Severe Hypophosphatasia
Taketani T, Oyama C, Mihara A, Tanabe Y, Abe M, Hirade T, Yamamoto S, Bo R, Kanai R, Tadenuma T, Michibata Y, Yamamoto S, Hattori M, Katsube Y, Ohnishi H, Sasao M, Oda Y, Hattori K, Yuba S, Ohgushi H, Yamaguchi S
Subcell Biochem   24(10) 1931-1943   Oct 2015   [Refereed]
Diffuse and multifocal nephrogenic adenoma with Familial Mediterranean Fever: a case report with molecular study
Ishikawa N, Amano C, Taketani T, Kumori K, Harada Y, Hiraiwa H, Itamura K, Maruyama R
Cell Transplant   10 104   Jul 2015   [Refereed]
Metabolic disease in 10 patients with sudden unexpected death in infancy or acute life-threatening events
Takahashi T, Yamada K, Kobayashi H, Hasegawa Y, Taketani T, Fukuda S, Yamaguchi S
Diagn Pathol   57(3) 348-353   Jun 2015   [Refereed]
Clinical and genetic investigation of 17 Japanese patients with hyperekplexia. Dev Med Child Neurol
Mine J, Taketani T, Yoshida K, Yokochi F, Kobayashi J, Maruyama K, Nanishi E, Ono M, Yokoyama A, Arai H, Tamaura S, Suzuki Y, Otsubo S, Hayashi T, Kimura M, Kishi K, Yamaguchi S
Pediatr Int   57(4) 372-377   Apr 2015   [Refereed]
Neurological Symptoms of Hypophosphatasia
Taketani T
Mol Genet Metab Rep   76 309-322   2015   [Refereed]
Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan
Moriwaki K, Manabe A, Taketani T, Kikuchi A, Nakahata T, Hayashi Y
Dev Med Child Neurol   100(5) 478-484   Nov 2014   [Refereed]
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis
Onishi C, Mori-Kimachi S, Hirade T, Abe M, Taketani T, Suzumiya J, Sugimoto T, Yamaguchi S, Kapur R, Fukuda S
Int J Hematol   289(45) 31053-31065   Nov 2014   [Refereed]
Simple and rapid detection of HLA-A*31:01 for prediction of carbamazepine-induced hypersensitivity using loop-mediated isothermal amplification method
Niihara H, Kohno K, Taketani T, Kaneko S, Ito T, Sugamori T, Takahashi N, Miyaoka T, Okazaki S, Yasuda H, Furuya M, Nagahama M, Morita E
J Biol Chem   74(1) 88-92   Apr 2014   [Refereed]
Clinical and genetic aspects of hypophosphatasia in Japanese patients
Taketani T, Onigata K, Kobayashi H, Mushimoto Y, Fukuda S, Yamaguchi S
J Dermatol Sci   99(3) 211-215   Mar 2014   [Refereed]
Ectopic neuroblastoma in monozygotic twins with different ages of onset: possible twin-to-twin metastasis in utero with distinct genetic alterations after birth
Taketani T, Takita J, Ueyama J, Kanai R, Kumori K, Maruyama R, Hayashi K, Ogawa S, Fukuda S, Yamaguchi S
Arch Dis Child   36(2) 166-168   Mar 2014   [Refereed]
A 14-year-old girl with hyperekplexia having GLRB mutations
Mine J, Taketani T, Otsubo S, Kishi K, Yamaguchi S
J Pediatr Hematol Oncol   35(7) 660-663   Aug 2013   [Refereed]
Low-density lipoprotein as a biomarker for the mobilization of hematopoietic stem cells in peripheral blood
Ishihara T, Mishima S, Kodama R, Yoshino I, Adachi E, Suyama T, Shibata H, Taketani T, Nagai A
Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi   49(3) 539-541   Dec 2013   [Refereed]
A case with sacrococcygeal primitive myxoid mesenchymal tumor of infancy: a case report and review of the literature
Saito A, Taketani T, Kanai R, Kanagawa T, Kumori K, Yamamoto N, Ishikawa N, Takita J, Yamaguchi S
Transfus Apher Sci   35(7) 280-282   Oct 2013   [Refereed]
Therapy-related Ph+ leukemia after both bone marrow and mesenchymal stem cell transplantation for hypophosphatasia
Taketani T, Kanai R, Abe M, Mishima S, Tadokoro M, Katsube Y, Yuba S, Ogushi H, Fukuda S, Yamaguchi S
Brain Dev.   55(3) 52-55   Jun 2013   [Refereed]
Bezafibrate can be a new treatment option for mitochondrial fatty acid oxidation disorders: evaluation by in vitro probe acylcarnitine assay
Yamaguchi S, Li H, Purevsuren J, Yamada K, Furui M, Takahashi T, Mushimoto Y, Kobayashi H, Hasegawa Y, Taketani T, Fukao T, Fukuda S
Pediatr Int   107 87-91   Sep 2012   [Refereed]
Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)
Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K,Takahashi Y, Kojima S, Kato K
Mol Genet Metab   95(5) 577-580   May 2012   [Refereed]
Clinical and molecular investigation of 19 Japanese cases of glutaric acidemia type 1
Mushimoto Y, Fukuda S, Hasegawa Y, Kobayashi H, Purevsuren J, Li H, Taketani T, Yamaguchi S
Int J Hematol   102(3) 343-348   Mar 2011   [Refereed]
Survivin selectively modulates genes deregulated in human leukemia stem cells
Fukuda S, Abe M, Onishi C, Taketani T, Purevsuren J, Yamaguchi S, Conway EM, Pelus LM
Mol Genet Metab   2011    Jan 2011   [Refereed]
High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes
Taketani T, Taki T, Nakamura T, Kobayashi Y, Ito E, Fukuda S, Yamaguchi S, Hayashi Y
J Oncol   24(11) 1975-1977   Dec 2010   [Refereed]
Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent
Mishima S, Nagai A, Abdullah S, Matsuda C, Taketani T, Kumakura S, Shibata H, Ishikura H, Kim SU, Masuda J
Leukemia   84(6) 538-546   Jun 2010   [Refereed]
Familial outbreak of Yersinia enterocolitica serotype O9 biotype 2
Moriki S, Nobata A, Shibata H, Nagai A, Minami N, Taketani T, Fukushima H
Eur J Haematol   16(1) 56-58   Feb 2010   [Refereed]
Pure red cell precursor toxicity by linezolid in a pediatric case
Taketani T, Kanai R, Fukuda S, Uchida Y, Yasuda K, Mishima S, Suyama T, Kodama R, Yoshino I, Kunishi H, Yamaguchi S, Masuda J
J Infect Chemother   31(9) 684-686   Sep 2009   [Refereed]
Septic shock induced by Lecythophora mutabilis in a patient with mitochondrial encephalomyopathy
Taniguchi Y, Taketani T, Moriyama H, Moriki S, Nishimura K, Sato E, Notsu Y, Higuchi T, Sugitani Y, Yasuda K, Nagai A, Yamaguchi S, Shibata H, Masuda J
J Pediatr Hematol Oncol   58(9) 1255-1258   Sep 2009   [Refereed]
Enzymatic evaluation of glutaric acidemia type 1 by an in vitro probe assay of acylcarnitine profiling using fibroblasts and electrospray ionization/tandem mass spectrometry (MS/MS)
Mushimoto Y, Hasegawa Y, Kobayashi H, Li H, Purevsuren J, Nakamura I, Taketani T, Fukuda S, Yamaguchi S
J Med Microbio   877(25) 2648-2651   Sep 2009   [Refereed]
Pharmaceutical analysis and clinical efficacy of Kampo medicine, maoto, extract suppository against pediatric febrile symptoms
Nishimura N, Doi N, Uemura T, Taketani T, Hayashi G, Kasai T, Kanai R, Yamaguchi S, Iwamoto K, Naora K
J Chromatogr B Analyt Technol Biomed Life Sci   129(6) 759-766   Jun 2009   [Refereed]
NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes
Taketani T, Taki T, Nakamura H, Taniwaki M, Masuda J, Hayashi Y
Yakugaku Zasshi   190(2) 108-112   Apr 2009   [Refereed]
Clinical and electrophysiological features of Japanese pediatric long QT syndrome patients with KCNQ1 mutations
Yasuda K, Hayashi G, Horie A, Taketani T, Yamaguchi S
Cancer Genet Cytogenet   50(5) 611-614   Oct 2008   [Refereed]
MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines
Taketani T, Taki T, Sako M, Ishii T, Yamaguchi S, Hayashi Y
Cancer Genet Cytogenet   186(2) 115-119   Oct 2008   [Refereed]
Neonatal isoimmune thrombocytopenia caused by type I CD36 deficiency having novel splicing isoforms of the CD36 gene
Taketani T, Ito K, Mishima S, Kanai R, Uchiyama A, Hirata Y, Kumakura S, Ishikura H, Yamaguchi S
Cancer Genet Cytogenet   81(1) 70-74   Jul 2008   [Refereed]
Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A
Horie A, Akimoto M, Tsumura H, Makishima M, Taketani T, Yamaguchi S, Honma Y
Eur J Haematol   32(7) 1112-1123   Jul 2008   [Refereed]
Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese childhood AML Cooperative Study Group
Shimada A, Taki T, Tabuchi K, Taketani T, Hanada R, Tawa A, Tsuchida M, Horibe K, Tsukimoto I, Hayashi Y
Cancer Genet Cytogenet   50(2) 264-269   Feb 2008   [Refereed]
Mutations of GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis
Kawamura M, Kaku H, Taketani T, Taki T, Shimada A, Hayashi Y
Leuk Res   180(1) 74-78   Jan 2008   [Refereed]
AML1 mutation and FLT3-internal tandem duplication in leukemia transformed from myelodysplastic syndrome
Shimada A, Taketani T, Kikuchi A, Hanada R, Arakawa H, Kimura H, Chen Y, Hayashi Y
Pediatr Blood Cancer   29(9) 666-667   Sep 2007   [Refereed]
Two Japanese families with hyperekplexia who have a Arg271Gln mutation in the glycine receptor alpha 1 subunit gene
Kimura M, Taketani T, Horie A, Isumi H, Sejima H, Yamaguchi S
J Pediatr Hematol Oncol   28(4) 228-231   Mar 2006   [Refereed]
TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease
Kanazawa T, Ogawa C, Taketani T, Taki T, Hayashi Y, Morikawa A
Brain Dev   46(12) 1833-1835   Dec 2005   [Refereed]
A case of hyperinsulinism/hyperammonaemia syndrome: usefulness of the oral protein tolerance for the evaluation of treatment
Toriumi Y, Murata K, Taketani T, Uchiyama A, Ohie T, Yamaguchi S
Leuk Lymphoma   164(3) 182-183   Mar 2005   [Refereed]
In vitro drug resistance to imatinib and mutation of ABL gene in childhood Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
Kawaguchi H, Taketani T, Hongo T, Park MJ, Koh K, Ida K, Kobayashi M, Takita J, Taki T, Yoshino H, Bessho F, Hayashi Y
Eur J Pediatr   46(2) 273-276   Feb 2005   [Refereed]
Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome
Xu G, Nagano M, Kanezaki R, Toki T, Hayashi Y, Taketani T, Taki T, Mitui T, Koike K, Kato K, Imaizumi M, Sekine I, Ikeda Y, Hanada R, Sako M, Kudo K, Kojima S, Ohneda O, Yamamoto M, Ito E
Blood   102(8) 2960-2968   Oct 2003   [Refereed]
AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies
Taketani T, Taki T, Takita J, Tsuchida M, Hanada R, Hongo T, Kaneko T, Manabe A, Ida K, Hayashi Y
Blood   38(1) 1-7   Sep 2003   [Refereed]
Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements
Tsutsumi S, Taketani T, Nishimura K, Ge X, Taki T, Sugita K, Ishii E, Hanada R, Ohki M, Aburatani H, Hayashi Y
Genes Chromosomes Cancer   63(16) 4882-4887   Aug 2003   [Refereed]
Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)
Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y
Cancer Res   22(18) 2851-28515   May 2003   [Refereed]
Successful treatment of acute myelomonocytic leukaemia with NUP98-HOXD11 fusion transcripts and monitoring of minimal residual disease
Terui K, Kitazawa J, Takahashi Y, Tohno C, Hayashi Y, Taketani T, Taki T, Ito E
Oncogene   120(2) 274-276   Jan 2003   [Refereed]
Mutation of the AML1/RUNX1 gene in a transient myeloproliferative disorder patient with Down syndrome
Taketani T, Taki T, Takita J, Ono R, Horikoshi Y, Kaneko Y, Sako M, Hanada R, Hongo T, Hayashi Y
Br J Haematol   16(9) 1866-1867   Sep 2002   [Refereed]
Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13)
Taketani T, Taki T, Shibuya N, Kikuchi A, Hanada R, Hayashi Y
Leukemia   62(16) 4571-4574   Aug 2002   [Refereed]
LCX,leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y
Genes Chromosomes Cancer   62(14) 4075-4080   Jul 2002   [Refereed]
SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24
Ono R, Taki T, Taketani T, Kawaguchi H, Taniwaki M, Okamura T, Kawa K, Hanada R, Kobayashi M, Hayashi Y
Cancer Res   62(2) 333-337   Jan 2002   [Refereed]
The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)
Taketani T, Taki T, Shibuya N, Ito E, Kitazawa J, Terui K, Hayashi Y
Cancer Res   62(1) 33-37   Jan 2002   [Refereed]
Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation
Liu M, Taketani T, Li R, Takita J, Taki T, Yang HW, Kawaguchi H, Ida K, Matsuo Y, Hayashi Y
Cancer Res   25(6) 441-447   Jun 2001   [Refereed]
Coduplication of the MLL and FLT3 genes in patients with acute myeloid leukemia
Jamal R, Taketani T, Taki T, Bessho F, Hongo T, Hamaguchi H, Horiike S, Taniwaki M, Hanada R, Nakamura H, Hayashi Y.
Leuk Res   31(2) 187-190   Jun 2001   [Refereed]

Association Memberships


Research Grants & Projects

Project Year: 1999