論文

査読有り
2006年11月

Synthesis and photochemical properties of a new water-soluble coumarin, designed as a chromophore for highly water-soluble and photolabile protecting group

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
  • Naoko Senda
  • ,
  • Atsuya Momotake
  • ,
  • Yoshinobu Nishimura
  • ,
  • Tatsuo Arai

79
11
開始ページ
1753
終了ページ
1757
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
CHEMICAL SOC JAPAN

The absorption spectra and fluorescence spectra of a coumarin derivative (1), designed to be a water-soluble photo-labile protecting group for caged compounds, were successfully observed in aqueous buffer solutions at pH 2.0-12.5 for the first time. Coumarin 1 is highly soluble (> 5 mM) in aqueous buffer at pH 7.2 and is stable in the dark at room temperature for up to a week. The pK(a) value for the protonation of anilino nitrogen in coumarin 1 was determined to be 4.5. Coumarin I has a fluorescence lifetime of 2.0 ns and undergoes intersystem crossing to the triplet state. Therefore, compound 1 can be used for the light absorbing part of the new water-soluble caged compounds, such as caged amino acids or caged nucteotides, which can release free amino acids or nucleotides, respectively, by excitation in the visible region.

Web of Science ® 被引用回数 : 13

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000243276100015&DestApp=WOS_CPL
ID情報
  • ISSN : 0009-2673
  • eISSN : 1348-0634
  • Web of Science ID : WOS:000243276100015

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