2021年4月
Molecular Recognition of G-quadruplex DNA by Pheophorbide a
Chemistry Letters
- ,
- ,
- ,
- 巻
- 50
- 号
- 6
- 開始ページ
- 1278
- 終了ページ
- 1281
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.210130
- 出版者・発行元
- CHEMICAL SOC JAPAN
Pheophorbide a (Phed-a), a naturally occurring chlorophyll catabolite, has been receiving much attention as a biologically-derived photosensitizer in photodynamic therapy (PDT) because of its high phototoxicity even in anoxic environments. Interaction of phed-a with G-quadruplex DNAs possessing a variety of folding topologies has been investigated to elucidate the molecular recognition of G-quadruplex DNA by phed-a, which is crucial to determine its PDT efficacy in tumor hypoxia. We found that phed-a binds selectively to the 3'-terminal G-quartet of parallel G-quadruplex DNAs.
- リンク情報
- ID情報
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- DOI : 10.1246/cl.210130
- ISSN : 0366-7022