論文

査読有り
2021年4月

Molecular Recognition of G-quadruplex DNA by Pheophorbide a

Chemistry Letters
  • Okamoto, China
  • ,
  • Momotake, Atsuya
  • ,
  • Kobayashi, Masami
  • ,
  • Yamamoto, Yasuhiko

50
6
開始ページ
1278
終了ページ
1281
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1246/cl.210130
出版者・発行元
CHEMICAL SOC JAPAN

Pheophorbide a (Phed-a), a naturally occurring chlorophyll catabolite, has been receiving much attention as a biologically-derived photosensitizer in photodynamic therapy (PDT) because of its high phototoxicity even in anoxic environments. Interaction of phed-a with G-quadruplex DNAs possessing a variety of folding topologies has been investigated to elucidate the molecular recognition of G-quadruplex DNA by phed-a, which is crucial to determine its PDT efficacy in tumor hypoxia. We found that phed-a binds selectively to the 3'-terminal G-quartet of parallel G-quadruplex DNAs.

リンク情報
DOI
https://doi.org/10.1246/cl.210130
ID情報
  • DOI : 10.1246/cl.210130
  • ISSN : 0366-7022

エクスポート
BibTeX RIS