2008年1月
Behavior of host and graft cells in the early remodeling process of rotator cuff defects in a transgenic animal model
JOURNAL OF SHOULDER AND ELBOW SURGERY
- 巻
- 17
- 号
- 1
- 開始ページ
- 101S
- 終了ページ
- 107S
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jse.2007.07.008
- 出版者・発行元
- MOSBY-ELSEVIER
Autologous tissue graft is one of the treatment options for a large rotator cuff defect. To develop appropriate strategies for enhanced solid graft integration at the bone-tendon interface and tendon-tendon interface, clarifying the fate of the graft and host cells that contribute to repair and remodeling is necessary. We have developed a new grafting model using green fluorescent protein-transgenic rats and wild-type rats to simulate autologous transplantation for examining the behavior of the host and graft cells in the remodeling process after tendon grafting. We found that the host cells commenced proliferation in the graft at 1 day after grafting. The host cells infiltrated into the graft from the subacromial synovium, proximal tendon, and bone-tendon insertion. The number of graft-derived cells decreased with time. Our result clearly demonstrated that host cells, rather than graft cells, were essential for rotator cuff remodeling after tendon grafting for rotator cuff defect.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.jse.2007.07.008
- ISSN : 1058-2746
- PubMed ID : 18162414
- Web of Science ID : WOS:000252883100018