論文

国際誌
2021年11月

Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA (rs1801274) on lung transplant outcomes among Japanese lung transplant recipients.

Transplant international : official journal of the European Society for Organ Transplantation
  • Hidenao Kayawake
  • Toyofumi F Chen-Yoshikawa
  • Satona Tanaka
  • Yuka Tanaka
  • Hideki Ohdan
  • Yojiro Yutaka
  • Yoshito Yamada
  • Akihiro Ohsumi
  • Daisuke Nakajima
  • Masatsugu Hamaji
  • Hiroto Egawa
  • Hiroshi Date
  • 全て表示

34
11
開始ページ
2192
終了ページ
2204
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/tri.13974

This study aimed to analyze the influences of single nucleotide polymorphisms (SNPs) in Fc gamma receptor IIA (FCGR2A) on postoperative outcomes after lung transplantation (LTx). We enrolled 191 lung transplant recipients (80 undergoing living-donor lobar lung transplants [LDLLTs] and 111 undergoing deceased-donor lung transplants [DDLTs]) in this study. We identified SNPs in FCGR2A (131 histidine [H] or arginine [R]; rs1801274) and reviewed the infectious complication-free survival after ICU discharge. The SNPs in FCGR2A comprised H/H (n=53), H/R (n=24), and R/R (n=3) in LDLLT, and H/H (n=67), H/R (n=42), and R/R (n=2) in DDLT. Recipients with H/H (H/H group) and those with H/R or R/R (R group) were compared in the analyses of infectious complications. In multivariate analyses, the R group of SNPs in FCGR2A was associated with pneumonia-free survival (HR: 2.52 [95% confidence interval {CI}: 1.35-4.71], p=0.004), fungal infection-free survival (HR: 2.50 [95% CI: 1.07-5.84], p=0.035), and cytomegalovirus infection-free survival (HR: 2.24 [95% CI: 1.07-4.69], p=0.032) in LDLLT but it was not associated with infectious complication-free survival in DDLT. Therefore, in LDLLT, more attention to infectious complications might need to be paid for LTx recipients with H/R or R/R than for those with H/H.

リンク情報
DOI
https://doi.org/10.1111/tri.13974
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34255889
ID情報
  • DOI : 10.1111/tri.13974
  • ORCIDのPut Code : 96926675
  • PubMed ID : 34255889

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