2002年
A patient with primary human immunodeficiency virus infection for whom highly active antiretroviral therapy was successful
Journal of Infection and Chemotherapy
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- 巻
- 8
- 号
- 4
- 開始ページ
- 361
- 終了ページ
- 364
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10156-002-0198-2
- 出版者・発行元
- Springer Japan
We report the case of a 25-year-old male Japanese homosexual with primary human immunodeficier virus (HIV)-1 infection and early stage syphilis. Approximately 60 days after HIV exposure by sex with another man, the patient abruptly had high fever, after which he experienced a variety of severe, prolonged symptoms such as painful oral mucosa ulcerations, rash, lymphadenopathy, splenomegaly, and a 5.5-kg weight loss. Serum lactate dehydrogenase and liver biochemical test values were elevated. Antibodies to HIV by both enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) test were negative at the time of symptom onset, but serum HIV-1 RNA level was 1585000 copies/ml. Antibody seroconversions were found on day 9 after the onset of symptoms by ELISA and on day 16 by WB test, suggesting primary HIV infection. Within 2 weeks of starting highly active antiretroviral therapy (HAART), all symptoms except lymphadenopathy were resolved, and the serum HIV-1 RNA level dramatically decreased to 5011 copies/ml, eventually becoming undetectable by the standard method. The patient has remained asymptomatic for the 18 months since symptom resolution after HAART, and HIV-1 RNA remains undetectable.
- リンク情報
- ID情報
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- DOI : 10.1007/s10156-002-0198-2
- ISSN : 1341-321X
- CiNii Articles ID : 10013893292
- PubMed ID : 12525900
- SCOPUS ID : 0036934477