2011年12月
Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)
DIABETOLOGIA
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- 巻
- 54
- 号
- 12
- 開始ページ
- 3028
- 終了ページ
- 3036
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00125-011-2310-6
- 出版者・発行元
- SPRINGER
Aims/hypothesis Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2-3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population.
Methods We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA(1c) and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG >= 7.0 mmol/l or HbA(1c) >= 6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively.
Results Glycated albumin levels were significantly correlated with HbA(1c) levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of >= 15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%.
Conclusions/interpretation There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.
Methods We studied 1,575 men and women (mean age, 49.9 years; range, 26-78 years) who participated in a periodic health examination in a suburban Japanese town. HbA(1c) and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG >= 7.0 mmol/l or HbA(1c) >= 6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively.
Results Glycated albumin levels were significantly correlated with HbA(1c) levels (r=0.766, p<0.001) and FPG (r=0.706, p<0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p=0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of >= 15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%.
Conclusions/interpretation There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.
- リンク情報
- ID情報
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- DOI : 10.1007/s00125-011-2310-6
- ISSN : 0012-186X
- Web of Science ID : WOS:000297740000009