Papers

Peer-reviewed
Jan, 2011

Deep Anesthesia Suppresses Ventricular Tachyarrhythmias in Rabbit Model of the Acquired Long QT Syndrome

CIRCULATION JOURNAL
  • Hideko Inaba
  • ,
  • Noriyuki Hayami
  • ,
  • Kosuke Ajiki
  • ,
  • Tomoyuki Kunishima
  • ,
  • Hidenori Watanabe
  • ,
  • Kenta Tsutsui
  • ,
  • Noboru Yamagishi
  • ,
  • Satoshi Yamagishi
  • ,
  • Anna Sugiura
  • ,
  • Takashi Mikamo
  • ,
  • Yuji Murakawa

Volume
75
Number
1
First page
89
Last page
93
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1253/circj.CJ-10-0478
Publisher
JAPANESE CIRCULATION SOC

Background: Anesthesia sometimes suppresses ventricular tachyarrhythmias (VT) resistant to conventional pharmacological treatment.
Methods and Results: To know (1) whether deep anesthesia inhibits abnormal repolarization-related VT and (2) if alpha 2-adrenoreceptor (AR) agonistic action is associated with the antiarrhythmic effect of anesthetics, the incidence of VT in a rabbit model of acquired long QT syndrome using different anesthetic regimen was assessed. In Study 1 (n=30), 15 rabbits were lightly anesthetized with ketamine (123 +/- 46 mg/kg) and an alpha 2-AR agonist, xylazine (9.4 +/- 3.0 mg/kg), while combination of these anesthetics at high doses were used in the other 15 rabbits (343 +/- 78 mg/kg and 38.9 +/- 3.0 mg/kg). Administration of alpha 1-AR stimulant, methoxamine and nifekalant (Ikr blocker) caused VT in all lightly anesthetized rabbits. In contrast, VT was observed only in 1 of the 15 deeply anesthetized rabbits (P<0.01). In Study 2 (n=15), 10 rabbits were anesthetized with high-dose ketamine and low-dose xylazine. In the other 5 rabbits, low-dose ketamine and high-dose xylazine were used. QTc interval in the latter was longer than that of the former (399 +/- 56 ms vs. 494 +/- 57 ms, P<0.01). Although no VT appeared in high/low-rabbits, VT occurred in 3 out of 5 low/high-rabbits (P<0.05).
Conclusions: These results suggest that (1) deep anesthesia suppresses abnormal repolarization-related VT and (2) antiarrhythmic effect of anesthesia on this type of VT is not dependent on a2-AR agonistic action. (Circ J 2011; 75: 89-93)


Link information
DOI
https://doi.org/10.1253/circj.CJ-10-0478
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000285814300016&DestApp=WOS_CPL
ID information
  • DOI : 10.1253/circj.CJ-10-0478
  • ISSN : 1346-9843
  • Web of Science ID : WOS:000285814300016

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