論文

査読有り
2000年9月

Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells

HYPERTENSION
  • U Ikeda
  • ,
  • M Shimpo
  • ,
  • R Ohki
  • ,
  • H Inaba
  • ,
  • M Takahashi
  • ,
  • K Yamamoto
  • ,
  • K Shimada

36
3
開始ページ
325
終了ページ
329
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Matrix metalloproteinase-1 (MMP-1), also called interstitial collagenase, may play an important role in the pathogenesis of atherosclerosis and atherosclerotic plaque rupture. We investigated the effects of fluvastatin on MMP-1 expression in human vascular endothelial cells (ECs). The addition of fluvastatin decreased the basal MMP-1 levels in the culture media of ECs in a time-dependent (0 to 48 hours) and dose-dependent (10(-8) to 10(-5) mol/L) manner. On the other hand, fluvastatin did not affect tissue inhibitor of metalloproteinase-1 levels. Collagenolytic activity in conditioned media of ECs was also dose-dependently reduced by fluvastatin. The effect of fluvastatin on MMP-1 expression was completely reversed in the presence of mevalonate or geranylgeranyl-pyrophosphate, but not in the presence of squalene. Inhibition of Rho by C3 exoenzyme also significantly decreased MMP-1 expression in ECs. Our findings revealed that fluvastatin decreases MMP-1 expression in human vascular ECs through inhibition of Rho.

Web of Science ® 被引用回数 : 98

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000089333800004&DestApp=WOS_CPL