Yoshitami Hashimoto

Profile Information

Affiliation: Graduate student, School of Life Science, Tokyo University of Pharmacy and Life Sciences

Degree: Master(Science)(Mar, 2004, Osaka University)

Researcher number: 50616761
J-GLOBAL ID: 200901064238718240
researchmap Member ID: 5000050422

Research Interests

Research Areas

Research History

May, 2011 - Present

Assistant professor, School of Life Science, Department of Medical Sciences, Tokyo University of Pharmacy and Life Sciences
Apr, 2007 - Mar, 2011

Postdoctoral Research fellow, Genome Stability, Cancer Research UK, London Research Institute, Clare Hall Laboratories
Apr, 2004 - Mar, 2007

日本学術振興会特別研究員PD, 生命機能研究科, 大阪大学大学院
1998 - 2000

扶桑薬品工業（株）研究員
1998 - 2000

Researcher, Fuso Pharmaceutical Industries,
Ltd

Education

Apr, 2000 - Mar, 2004

Osaka University
- 2004

Biological Science, Graduate School, Division of Natural Science, Osaka University
Apr, 1996 - Mar, 1998

Osaka University
- 1996

Kyoto Institute of Technology
- 1996

Applied Biology, Faculty of Textile Science and Technology, Kyoto Institute of Technology

Committee Memberships

Papers

Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation

Yoshitami Hashimoto, Kota Sadano, Nene Miyata, Haruka Ito, Hirofumi Tanaka

The EMBO Journal, e114131, Jul 17, 2023 Peer-reviewedLead authorCorresponding author
Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress

Yoshitami Hashimoto, Hirofumi Tanaka

Life Science Alliance, 5(6) e202101249-e202101249, Jun, 2022 Peer-reviewedLead authorCorresponding author
Ongoing replication forks delay nuclear envelope breakdown upon mitotic entry

Yoshitami Hashimoto, Hirofumi Tanaka

Journal of Biological Chemistry, jbc.RA120.015142-jbc.RA120.015142, Nov 4, 2020 Peer-reviewedLead authorCorresponding author
Mitotic entry drives replisome disassembly at stalled replication forks.

Yoshitami Hashimoto, Hirofumi Tanaka

Biochemical and biophysical research communications, 506(1) 108-113, Nov 17, 2018 Peer-reviewedLead authorCorresponding author
Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Arnab Ray Chaudhuri, Yoshitami Hashimoto, Raquel Herrador, Kai J. Neelsen, Daniele Fachinetti, Rodrigo Bermejo, Andrea Cocito, Vincenzo Costanzo, Massimo Lopes

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 19(4) 417-423, Apr, 2012 Peer-reviewed
RAD51-and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

Yoshitami Hashimoto, Fabio Puddu, Vincenzo Costanzo

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 19(1) 17-U30, Jan, 2012 Peer-reviewedLead author
Studying DNA Replication Fork Stability in Xenopus Egg Extract

Yoshitami Hashimoto, Vincenzo Costanzo

Methods in Molecular Biology, 437-445, 2011 Lead author
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

Yoshitami Hashimoto, Arnab Ray Chaudhuri, Massimo Lopes, Vincenzo Costanzo

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 17(11) 1305-U268, Nov, 2010 Peer-reviewedLead author
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1

Yoshitami Hashimoto, Tsuyoshi Tsujimura, Akio Sugino, Haruhiko Takisawa

GENES TO CELLS, 11(9) 993-1007, Sep, 2006 Peer-reviewedLead author
The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication

K Matsuno, M Kumano, Y Kubota, Y Hashimoto, H Takisawa

MOLECULAR AND CELLULAR BIOLOGY, 26(13) 4843-4852, Jul, 2006 Peer-reviewed
A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication

Y Kubota, Y Takase, Y Komori, Y Hashimoto, T Arata, Y Kamimura, H Araki, H Takisawa

GENES & DEVELOPMENT, 17(9) 1141-1152, May, 2003 Peer-reviewed
Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication

Y Hashimoto, H Takisawa

EMBO JOURNAL, 22(10) 2526-2535, May, 2003 Peer-reviewedLead author
A Single Nucleotide Insertion in the 5′-Untranslated Region of Hepatitis C Virus Leads to Enhanced Cap-Independent Translation

Jing Zhang, Osamu Yamada, Takayoshi Ito, Masaki Akiyama, Yoshitami Hashimoto, Hiroshi Yoshida, Reiko Makino, Akinori Masago, Hidetoshi Uemura, Hiromasa Araki

Virology, 261(2) 263-270, Sep, 1999 Peer-reviewed
cDNA cloning and expression during development of Drosophila melanogaster MCM3, MCM6 and MCM7

Katsuhito Ohno, Fumiko Hirose, Yoshihiro H. Inoue, Haruhiko Takisawa, Satoru Mimura, Yoshitami Hashimoto, Tohru Kiyono, Yasuyoshi Nishida, Akio Matsukage

Gene, 217(1-2) 177-186, Sep, 1998 Peer-reviewed

Misc.

DNA複製装置、レプリソームの形成・維持を制御する機構

久保田弓子, 橋本吉民, 滝澤温彦

化学と生物, 43巻8号 519-527頁(8) 519-527, 2005

Books and Other Publications

基礎講義分子生物学 : アクティブラーニングにも対応

田中弘文, 井上英史 (Role: Contributor, 第５章（５−３真核生物のDNA複製）橋本吉民)

東京化学同人, Sep, 2020 (ISBN: 9784807909971)

Professional Memberships

Research Projects

Studying the molecular mechanism of replisome disassembly in mitosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Hashimoto Yoshitami
複製フォーク崩壊過程におけるレプリソーム動態制御

科学研究費補助金基盤研究（C）, 文部科学省, Apr, 2015 - Mar, 2018

橋本吉民
Roles of syntaxin 17 in the formation and function of the mitochondria-associated ER membrane

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

TAGAYA MITSUO, INOUE Hiroki, HASHIMOTO Yoshitami, ARASAKI Kohei
一方向からDNA鎖間架橋と衝突した複製フォークのプロセシング機構の解析

科学研究費補助金新学術領域研究（研究領域提案型）, 文部科学省, Apr, 2013 - Mar, 2015

橋本吉民
真核生物における組換え依存的複製再開機構の解明

科学研究費補助金若手研究（Ｂ）, 文部科学省, Apr, 2012 - Mar, 2015

橋本吉民
DNA複製モニター機構の試験管内再構成

科学研究費補助金特別研究員奨励費, 文部科学省, Apr, 2004 - Mar, 2006

橋本吉民
Cell Cycle Control

Gene Science Research, 2000 - 2004

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Papers

Misc.

Books and Other Publications

Professional Memberships

Research Projects

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