2018年9月
PTH202 Pharmacological Studies of Spinal Cannabinoid Receptor Subtypes in a Rat Model of Trigeminal Neuropathic Pain
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- 記述言語
- 英語
- 掲載種別
Cannabinoidreceptorsarefamousfortheirimportantroleinpain.Inthisstudy,weconductedtheexperimentstorevealtheroleofcannabinoid(CB)receptorsinthespinallevelusingorofacialneuropathicpainmodelintherat.CB1receptorantagonistSR141716Ashowedtheeffecttoincreasemechanicalthresholdafterspinalinjection.CB2receptoragonistHU308alsoaffectedthemechanicalthresholdafterinjectionlikeCB1antagonist.Ontheotherhands,therewasnoeffectstothemechanicalthresholdafterCB1agonistR(+)-MethanandamideandCB2antagonistAM630injectiontothespinalcord.TheseresultssuggestedthatthepathwayrelatedtoCB1andCB2receptorshavetheoppositeeffectsinthespinalcord.