ISHISAKI Akira

J-GLOBAL         Last updated: Apr 16, 2019 at 15:11
 
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Name
ISHISAKI Akira
E-mail
aishisaiwate-med.ac.jp
Affiliation
Iwate Medical University
Section
Division of Cellular Biosignal Sciences, Department of Biochemistry
Job title
Professor
Degree
PhD (Dentistry)(Tokyo Medical and Dental University)
Research funding number
20356439

Research Areas

 
 

Academic & Professional Experience

 
Apr 2011
 - 
Today
Professor, Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University
 
Jul 2008
 - 
Mar 2011
Professor, Department of Oral Biochemistry, Iwate Medical School of Dentistry
 
2005
 - 
2008
Associate Professor, Division of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University
 
2003
 - 
2005
Instructor, Department of Pharmacology, Gifu University Graduate School of Medicine
 
2002
 - 
2003
Senior Research Scientist, AIST
 
1998
 - 
2002
NEDO Fellow, National Institute of Advanced Industrial Science and Technology (AIST)
 
1997
 - 
1998
Post-Doctoral Fellow, Japan Health Sciences Foundation (National Institute of Infectious Diseases)
 
1994
 - 
1997
Post-Doctoral Fellow, Ludwig Institute for Cancer Research (Upplasa Branch)
 

Education

 
Apr 1989
 - 
Mar 1993
Graduate School, Division of Dental Research, Tokyo Medical and Dental University
 
Apr 1982
 - 
Mar 1988
Faculty of Dentistry, Tokyo Medical and Dental University
 

Committee Memberships

 
Apr 2019
 - 
Today
Molecular Medicine Reports  Editorial Board member
 
Apr 2016
 - 
Today
Editor-in-Chief  Dental Journal of Iwate Medical University
 
Jul 2015
 - 
Today
The Japanese Dental Science Review  Editorial Board
 
Jan 2014
 - 
Today
Journal of Biochemistry  Advisory Board
 
2014
 - 
Today
Japanese Society of Oral Implantology  Editorial Advisory Board
 
2012
 - 
Today
Journal of Oral Biosciences  Associate Editor
 
2010
 - 
Today
The Stomatological Society, Japan  Councilor
 
2009
 - 
Today
Japan Tissue Culture Society for Dental Research  Director
 
2009
 - 
Today
The Japanese Dental Education Association  Councilor
 
2009
 - 
Today
The Japanese Biochemical Society  Councilor
 
2008
 - 
Today
Iwate Association for Dental Science  Councilor
 
2005
 - 
Today
Hokkaido Association for Dental Science  Councilor
 
2005
 - 
Today
The Japanese Association for Oral Biology  Councilor
 

Awards & Honors

 
1994
The Fellowship from The Japan-Sweden Foundation
 

Published Papers

 
Novel strategy for regenerative medicine with mesenchymal stem cells
ISHISAKI Akira
Ochanomizu igaku zasshi   66 247-258   2018   [Refereed]
Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint.
Ibi, M., Horie, S., Kyakumoto, S, Chosa, N., Yoshida, M., Kamo, M., Ohtsuka, M., and Ishisaki, A.
Biosci. Rep.   38 BSR20171217   2018   [Refereed]
*Ohta, M., *Nemoto, A., Chosa, N., Kyakumoto, S., Yokota, S., Kamo, M., Shibata, S., Joh, S., Satoh, K., Ishisaki, A. *Co-first authors.
Dent. J Iwate Med. Univ.   43 61-73   2018   [Refereed]
IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3-, and p38 MAPK-mediated signals.
Ohta, M., Chosa, N., Kyakumoto, S., Yokota, S., Okubo, N., Nemoto, A., Kamo, M., Joh, S., Satoh, K., and Ishisaki A.
Int. J. Mol. Med.   43 1484-1494   2018   [Refereed]
Chosa, N., and Ishisaki, A.
Jpn. Dent. Sci. Rev.   54 37-44   2018   [Refereed][Invited]
Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells.
Nemoto, A., Chosa, N., Kyakumoto, S., Yokota, S., Kamo, M., Noda, M., and Ishisaki, A.
Mol. Med. Rep.   17 3448-3454   2018   [Refereed]
Inoue, M., Ohtsu, K., Ohtsuka, M., Takafuji, K., Harada, H., Ishisaki, A., Kondo, H.
J. Oral Tissue Eng.   14 74-85   2017   [Refereed]
SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells.
Inoue, M., Yamada, J, Aomatsu-Kikuchi, E., Satoh, K., Kondo, H., Ishisaki, A., and Chosa N.
Mol. Med. Rep.   15 4069-4076   2017   [Refereed]
ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint.
Yokota, S., Chosa, N., Kyakumoto, S., Kimura, H., Ibi, M., Kamo, M., Satoh, K., and Ishisaki, A.
Int. J. Mol. Med.   39 799-808   2017   [Refereed]
*Takizawa, N., *Okubo, N., Kamo, M., Chosa, N., Mikami, T., Suzuki, K., Yokota, S., Ibi, M., Ohtsuka, M., Taira, M., Yaegashi, T., Ishisaki, A., and Kyakumoto, S. *Co-first authors.
Exp. Cell Res.   358 411-420   2017   [Refereed]

Books etc

 
Oral Bioscience (6th Edition)
Akira Ishisaki (Part:Joint Work)
Ishiyaku Publishers, Inc.   Sep 2018   
Angiogenic capacity of periodontal ligament-derived stem cells. [Advances in oral tissue engineering. Murata M. & Um IW. (ed.)]
Okubo, N. & Ishisaki, A. (Part:Joint Work, Pages 9 to 14)
Quintessence Publishing   2014   
Interface oral health science 2011.
Sasaki, K. (ed.) (Part:Joint Work, Eatablishment of periodontal ligament cell line derived from human deciduous teeth (5th in 6 authors) Regulation of SDF-1 expression in periodontal ligament cells derived from human permanent teeth(5th in 6 authors))
Springer, New York   Mar 2012   
Oral Biochemistry (5th Edition)
Akira Ishisaki (Part:Joint Work)
Ishiyaku Publishers. Inc.   Jul 2011   

Conference Activities & Talks

 
Biological effects of extracellular nucleotides on fibroblast-like synovial cells derived from TMJ
Matsumoto S, Yokota S, Chosa N, Kikuchi E, Kimura H, Kamo M, Stach K, Ishisaki A
The 43rd Annual Meeting of the Molecular Biology Society of Japan   Nov 2018   
Roles of Sox9 and Hippo pathway on epithelial-mesenchymal transition in human squamous cell carcinoma cells.
Hirano T, Takeda K, Saito D, Shibata T, Yamada H, Ishisaki A, Kamo M
The 43rd Annual Meeting of the Molecular Biology Society of Japan   Nov 2018   
Biological effects of prinergic receptor-mediated signals on fibroblast-like synovial cells derived from TMJ
Yokota S, Chosa N, Matsumoto S, Kyakumoto S, Kamo M, Satoh K, Ishisaki A
The 43rd Annual Meeting of the Molecular Biology Society of Japan   Nov 2018   
Availability of in vitro-cultured immunosuppressive macrophages under hypoxic condition for periodontitis treatment
Takizawa N, Suzuki K, Itoh S, Murai O, Sasaki D, Kyakumoto S, Ishisaki A, Yaegashi T
The 61st Spring Meeting of the Japanese Society of Periodontology   Jun 2018   
Role of Hippo pathway on epithelial-to-mesenchymal transition in human squamous cell carcinoma cells
Hirano T, Saito D, Komatsu Y, Chiba T, Hino M, Yokota S, Kyakumoto S, Chosa N, Yamada H, Ishisaki A, Kamo M
The Japanese Biochemical Society, Tohoku Branch   May 2018   
Elucidation of molecular mechanisms underlying bone resorption of mandibular condyle in temporomandibular joint-osteoarthritis
Matsumoto S, Yokota S, Chose N, Kikuchi E, Himura H, Kamo M, Satoh K, Ishisaki A
Consortium of Biological Sciences (ConBio) 2017   Dec 2017   
Study on molecular mechanism of expression of nerve growth factor in periodontal ligament-derived cells
Ohta M, Chosa N, Yokota S, Kyakumoto S, Kamo M, Satoh K, Joh S, Ishisaki A
Consortium of Biological Sciences (ConBio) 2017   Dec 2017   
Water-soluble factors eluted from surface pre-reacted glass-ionomer promote osteoblastic differentiation of human mesenchymal stem cells
Nemoto A, Chosa N, Kyakumoto S, Yokota S, Kamo M, Noda M, Ishisaki A
Consortium of Biological Society (ConBio) 2017   Dec 2017   
Bone marrow-derived mesenchymeal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and –dependent manners under hypoxic culture
Kyakumoto S, Takizawa N, Okubo N, Kamo M, Chosa N, Yokota S, Ohtsuka M, Ibi M, Ishisaki A
Consortium of Biological Society (ConBio) 2017   Dec 2017   
Water-soluble factors eluted from dental material promote osteoblastic differentiation of human mesenchymal stem cells
Nemoto A, Shimizu S, Aoki T, Yokota S, Chosa N, Kyakumoto S, Kamo M, Sakurai H, Shiga H, Okada N, Asano A, Noda M, Ishisaki A
The 54th Annual Meeting of Japan Tissue Culture Society for Dental Research   Nov 2017   

Research Grants & Projects

 
Establishment of novel therapy for dentin regeneration by using GDF-5 and dental pulp stem cell niche
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2017 - Mar 2021    Investigator(s): Yuriko MARUYA (Project member: Akira ISHISAKI)
Elucidation of molecular mechanism underlying EMT/MET in oral squamous cell carcinoma cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2017 - Mar 2021    Investigator(s): Masaharu KAMO (Project member: Akira ISHISAKI)
Establishment of novel functionally graded implant therapy with dental pulp stem cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2016 - Mar 2021    Investigator(s): Jun TAKEBE (Project member: Akira ISHISAKI)
Establishment of novel therapy against refractory osteonecrosis of the jaw by using myofibroblasts and progenitors of vascular endothelial cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (B)
Project Year: Apr 2016 - Mar 2020    Investigator(s): Akira ISHISAKI
Establishment of novel therapy against refractory osteonecrosis of the jaw by using mesenchymal stem cells-propagated M2-macrophages
Japan Society for the Promotion of Science: Grants-in-Aid for Challenging Research (Exploratory)
Project Year: Apr 2017 - Mar 2019    Investigator(s): Akira ISHISAKI
Development of efficient and improved method for generation of iPS cells from human dental pulp stem cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (B)
Project Year: Apr 2014 - Mar 2019    Investigator(s): Toshiyuki SHIBATA (Project member: Akira ISHISAKI)
Establishment of novel therapy for periodontal tissue regeneration by application of angiogenic and hematopoietic abilities of periodontal ligament-derived cells
Japan Society for the Promotion of Science: Grants-in-Aid for Challenging Exploratory Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): Akira ISHISAKI
Novel bone regenerative therapy by application of gene transfer and nanobiomaterials
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2014 - Mar 2017    Investigator(s): Hisatomo KONDO (Project member: Akira ISHISAKI)
Elucidation of transforming mechanism underlying interaction between bone marrow-derived fibrocytes and oral carcinoma cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2014 - Mar 2017    Investigator(s): Seiko KYAKUMOTO (Project member: Akira ISHISAKI)
Elucidation of molecular mechanism of bovine mammary gland reconstruction in dry period
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: Apr 2015 - Mar 2016    Investigator(s): Keiichi NAKAJIMA (Project member: Akira ISHISAKI)