Chifumi FUJII - My portal

Profile Information

Affiliation: Assistant Professor, Interdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical Sciences , Department of Advanced Medicine for Health Promotion, Shinshu University

Degree: 博士（理学）(Mar, 2001, 金沢大学)
修士（理学）(Mar, 1998, 金沢大学)

J-GLOBAL ID: 200901010460725848
researchmap Member ID: 5000055353

Research History

Apr, 2014

信州大学学術研究院（医学系）助教バイオメディカル研究所主担当
Apr, 2013 - Mar, 2014

Graduate School of Medicine, Shinshu University
Apr, 2007 - Mar, 2013

信州大学医学部医学科助教
Apr, 2007 - Mar, 2013

School of Medicine, Department of Medicine, Shinshu University
Sep, 2006 - Mar, 2007

信州大学医学部医学科助手
Sep, 2006 - Mar, 2007

School of Medicine, Department of Medicine, Shinshu University
Apr, 2003 - Aug, 2006

金沢大学がん研究所助手
Apr, 2001 - Mar, 2003

金沢大学がん研究所非常勤研究員

Education

Apr, 1998 - Mar, 2001

Kanazawa University
Apr, 1996 - Mar, 1998

Kanazawa University
Apr, 1992 - Mar, 1996

Kanazawa University

Papers

Biological Defenses and Regulation of Epithelial Tumor Development by the Gastric Gland Mucus-type Glycan

FUJII Chifumi, NAKAYAMA Jun

Shinshu Medical Journal, 70(5) 257-269, Oct, 2022
α1,4-linked N-acetylglucosamine suppresses gastric cancer development by inhibiting Mucin-1-mediated signaling.

Fujii C (corresponding author), Harumiya S, Sato Y, Kawakubo M, Matoba H, Nakayama J.

Cancer Sci., in press(11) 3852-3863, 2022 Peer-reviewedLead authorCorresponding author
MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung.

Yamanoi K, Fujii C (co-first author), Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J.

Histochem. Cell Biol., 157(6) 671-684, 2022 Peer-reviewedLead author
Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.

Yuki A, Fujii C (co-first author, corresponding author), Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J.

Cancer Sci., 113 576-586, 2022 Peer-reviewedLead authorCorresponding author
Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL

Kobayashi J, Kawakubo M, Fujii C, Arisaka N, Miyashita M, Sato Y, Komura H, Matoba H, and Nakayama J

Proc. Natl. Acad. Sci. USA, 118 e2016469118, 2021 Peer-reviewed
Cecal tumorigenesis in Aryl hydrocarbon receptor-deficient mice depends on cecum-specific mitogen-activated protein kinase pathway activation and inflammation

Matoba H, Takamoto M*, Fujii C*,Kawakubo M, Kasuga E, Matsumura T, Natori T,Misawa K, Taniguchi S, and Nakayama J (*: Corresponding author)

Am. J. Pathol., 190 253-268, 2020 Peer-reviewedCorresponding author
Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda

Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, and Nakayama J

J. Histtochem. & Cytochem., 67 759-770, 2019 Peer-reviewed
Annexin A1 expression is correlated with malignant potential of renal cell carcinoma

Yamanoi M, Yamanoi K, Fujii C, Fukuda MN, Nakayama J, Contributed equally, Corresponding author

Int. J. Urol., 26 284-290, 2019 Corresponding author
Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer

Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI

J. Bilo. Chem., 293 6329-6336, 2018
Potential role of ASC, a proapoptotic protein, for determining the cisplatin susceptibility of lung cancer cells

Takao Sakaizawa, Tomio Matsumura, Chifumi Fujii, Shigeaki Hida, Masayuki Toishi, Takayuki Shiina, Kazuo Yoshida, Kazutoshi Hamanaka, Ken-Ichi Ito, Shun’ichiro Taniguchi

Tohoku Journal of Experimental Medicine, 244(2) 133-144, Jan 1, 2018
Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer

Ayumi Ohya, Kazuhiro Yamanoi, Hisashi Shimojo, Chifumi Fujii, Jun Nakayama

CANCER SCIENCE, 108(9) 1897-1902, Sep, 2017
ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction - Mediated Intercellular Communication

Masato Kitazawa, Shigeaki Hida, Chifumi Fujii, Shun'ichiro Taniguchi, Kensuke Ito, Tomio Matsumura, Nagisa Okada, Takashi Sakaizawa, Akira Kobayashi, Michiko Takeoka …

PLOS ONE, 12(1) e0169340, Jan, 2017
Novel role of ASC as a regulator of metastatic phenotype

Nagisa Okada, Chifumi Fujii, Tomio Matsumura, Masato Kitazawa, Ryuhei Okuyama, Shun'ichiro Taniguchi, Shigeaki Hida

CANCER MEDICINE, 5(9) 2487-2500, Sep, 2016 Lead authorCorresponding author
NFB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training

Y. Zhang, S. Hashimoto, C. Fujii, S. Hida, K. Ito, T. Matsumura, T. Sakaizawa, M. Morikawa, S. Masuki, H. Nose …

INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 36(9) 769-775, Aug, 2015
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

Y. Wu, Y. Y. Wang, Y. Nakamoto, Y-Y Li, T. Baba, S. Kaneko, C. Fujii, N. Mukaida

ONCOGENE, 29(15) 2228-2237, Apr, 2010
In vivo immunological toxicity in mice of carbon nanotubes with impurities

Shozo Koyama, Yoon Ahm Kim, Takuya Hayashi, Kenji Takeuchi, Chifumi Fujii, Naomi Kuroiwa, Haruhide Koyama, Tamotsu Tsukahara, Morinobu Endo

CARBON, 47(5) 1365-1372, Apr, 2009
Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

Hua-Chuan Zheng, Koichi Tsuneyama, Hiroyuki Takahashi, Shigeharu Miwa, Toshiro Sugiyama, Boryana Konstantinova Popivanova, Chifumi Fujii, Kazuhiro Nomoto, Naofumi Mukaida, Yasuo Takano

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 134(4) 481-488, Apr, 2008
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis

Boryana K. Popivanova, Kazuya Kitamura, Yu Wu, Toshikazu Kondo, Takashi Kagaya, Shiuchi Kaneko, Masanobu Oshima, Chifurni Fujii, Naofumi Mukaida

JOURNAL OF CLINICAL INVESTIGATION, 118(2) 560-570, Feb, 2008
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

Boryana Konstantinova Popivanova, Ying-Yi Li, Huachuan Zheng, Kenji Omura, Chifumi Fujii, Koichi Tsuneyama, Naofumi Mukaida

CANCER SCIENCE, 98(3) 321-328, Mar, 2007
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines

Ying-Yi Li, Boryana K. Popivanova, Yuichiro Nagai, Hiroshi Ishikura, Chifumi Fujii, Naofumi Mukaida

CANCER RESEARCH, 66(13) 6741-6747, Jul, 2006

Presentations

αGlcNAc binding to MUC6 enhances suppression of malignant phenotypes of pancreatic cancer cells

Sep, 2022
Phenotypic change of pyloric gland mucin represents potentially malignant biomarker for various neoplasm

Sep, 2022
Regulation of pancreatic cancer malignancy by αGlcNAc and MUC6

Jul, 2022
淡明細胞型腎細胞癌にて悪性度と相関するアネキシンA1は、紡錘細胞型腎細胞癌でも発現した

山ノ井万里子、藤井千文、山ノ井一裕、中山淳

第109回日本泌尿器科学会総会, Dec, 2021
MUC6発現は、粘液産生型肺腺癌における予後良好の指標になる

山ノ井一裕、藤井千文、中山淳、下田将之

第79回日本癌学会学術総会, Oct, 2021
胃腺粘液特異的糖鎖αGlcNAcによる胃がん細胞でのMUC1シグナル伝達制御

藤井千文、中山淳

第79回日本癌学会学術総会, Oct, 2021
胃腺粘液特異的糖鎖αGlcNAc結合新規タンパク質の同定と胃がん細胞における役割

藤井千文、佐藤佳子、春宮覚、川久保雅友、中山淳

第28回日本がん転移学会学術集会, Jul, 2021
αGlcNAcとMUC6による膵癌の悪性化制御機能

結城淳子、藤井千文、中山淳

第118回日本内科学会講演会, Apr, 2021
Sirt3のノックダウンはライディッヒ細胞腫由来細胞株MA-10にROS依存性の細胞死を誘導する

的場久典、藤井千文、川久保雅友、丸山和晃、中山淳

第110回日本病理学会総会, Apr, 2021
胃腺粘液特異的糖鎖αGlcNAcはがん細胞の悪性度を制御する

藤井千文、中山淳

第79回日本癌学会学術総会, Oct, 2020
AhRノックアウトマウスの回盲部における腫瘍発生は回盲部に特異的なMAPK経路の活性化と炎症反応に依存する

的場久典、高本雅哉、藤井千文、川久保雅友、春日恵理子、松村富穂、名取達矢、三沢健、谷口俊一郎、中山淳

第109回日本病理学会総会, Jul, 2020
胃腺粘液特異的糖鎖αGlcNAcによる胃がん細胞の悪性化制御機構

藤井千文、佐藤佳子、春宮覚、川久保雅友、中山淳

第29回日本がん転移学会, 2020
Gastritis Cystica Profundaの発生抑制における胃スルホムチンの役割の解明（神戸）

川久保雅友、小村仁美、五艘行信、奥村征大、佐藤佳子、藤井千文、宮下聖基、有坂宣彦、春宮覚、山ノ井一裕、山田重徳、角田茂、川島博人、福田道子、福田穰、中山淳

第60回日本組織細胞化学会総会・学術集会および第13回日中組織細胞化学セミナー合同大会（神戸）, Sep, 2019
Role of gastric gland mucin-specific O-glycan GlcNAc in gastric cancer development

Chifumi Fujii, Atsuko Yuki, Satoru Harumiya, Kazuhiro Yamanoi, Masatomo Kawakubo, Jun Nakayama

ASCB|EMBO meeting 2018(San Diego, USA), Dec, 2018
AhRノックアウトマウスの盲腸への腫瘍発生およびそれに対する腸内細菌叢の影響に関する研究

的場久典, 藤井千文, 谷口俊一郎, 中山淳

第77回日本癌学会学術集会（大阪）, Sep, 2018
腎細胞がんにおけるAnnexinA1発現の意義

山ノ井万里子, 山ノ井一裕, 藤井千文, 福田道子, 中山淳

第77回日本癌学会学術集会（大阪）, Sep, 2018
胃腺粘液特異的糖鎖αGlcNAcはがん細胞の浸潤能を制御する

藤井千文, 結城淳子, 五十嵐悠真, 春宮覚, 山ノ井一裕, 川久保雅友, 中山淳

第91回日本生化学会大会（京都）, Sep, 2018
胃腺粘液特異的糖鎖であるαGlcNAcによる胃がん細胞の悪性化制御機構

藤井千文, 中山淳

第27回日本がん転移学会学術集会（横浜）, Jul, 2018
AhRノックアウトマウスの盲腸への腫瘍発生および腸内細菌叢の影響に関する研究

的場久典, 藤井千文, 川久保雅友, 春日恵理子, 高本雅哉, 谷口俊一郎, 中山淳

第107回日本病理学会総会（札幌）, Jun, 2018
腎細胞がんにおけるAnnexinA1発現の意義

山ノ井万里子, 藤井千文, 山ノ井一裕, 福田道子, 中山淳

第106回日本泌尿器科学会総会（京都）, Apr, 2018

Professional Memberships

Research Projects

胃腺粘液特異的糖鎖を指標とした予後不良分化型胃がんの診断・治療法開発

科学研究費補助金（基盤研究（Ｃ））, Apr, 2023
胃腺粘液糖鎖αGlcNAcの消失による胃がん悪性化の制御機構

科学研究費補助金（基盤研究（Ｃ））, Apr, 2018 - Mar, 2021
インフラマソーム構成分子ASCによるがん細胞の転移制御機構の解明

科学研究費補助金（基盤研究（Ｃ））, Apr, 2014 - Mar, 2017
アダプタータンパク質ASC下流シグナルを標的とした新規大腸がん治療標的分子の同定

科学研究費補助金（若手研究（Ｂ））, Apr, 2012 - Mar, 2014
新規素材カーボンナノチューブの毒性および発がん性評価

科学研究費補助金（若手研究（Ｂ））, Apr, 2009 - Mar, 2011