論文

査読有り
2021年

Effects of a Tea Cultivar "MK5601" on Behaviors and Hippocampal Neurotrophin-3 Levels in Middle-Aged Mice.

Journal of nutritional science and vitaminology
  • Sachiko Nomura
  • ,
  • Manami Monobe
  • ,
  • Kaori Ema
  • ,
  • Katsuyuki Yoshida
  • ,
  • Shuya Yamashita
  • ,
  • Akiko Ogino
  • ,
  • Atsushi Nesumi

67
3
開始ページ
170
終了ページ
179
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3177/jnsv.67.170
出版者・発行元
CENTER ACADEMIC PUBL JAPAN

Dietary factors are thought to play an important role in the prevention of cognition diseases and depression in late life. In the present study, we compared the effects between the theogallin-rich tea cultivar, "MK5601" and a common Japanese tea cultivar, "Yabukita" on behaviors and hippocampal neurotrophin levels in experimental animals. Middle-aged mice (aged 8 mo) were given either of the tea infusions or water ad libitum for 4 mo. In the novel object location test, the middle-aged mice drinking water or "Yabukita" performed worse than young mice (aged 2-3 mo) although the middle-aged mice drinking "MK5601" retained spatial memory at the same level as the young mice. We also found that the middle-aged mice drinking "MK5601" showed high levels of neurotrophin-3 in the hippocampus. In conclusion, the "MK5601" tea infusion appears to be effective in preventing age-related changes in cognitive function, as compared with a common Japanese tea cultivar.

リンク情報
DOI
https://doi.org/10.3177/jnsv.67.170
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34193676
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000667993700004&DestApp=WOS_CPL
ID情報
  • DOI : 10.3177/jnsv.67.170
  • ISSN : 0301-4800
  • eISSN : 1881-7742
  • PubMed ID : 34193676
  • Web of Science ID : WOS:000667993700004

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