Ishii Isao

J-GLOBAL         Last updated: Oct 16, 2018 at 19:27
 
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Name
Ishii Isao
Affiliation
Showa Pharmaceutical University
Section
Department of Health Chemistry
Job title
Professor
Research funding number
90292953
ORCID ID
0000-0002-5367-205X

Research Areas

 

Awards & Honors

 
2006
皮膚表皮層構造におけるシステイン生合成系の役割, 中冨健康科学振興財団研究助成
Winner: Ishii Isao
 
2005
細胞膜受容体欠損マウスを用いたスフィンゴシン1リン酸の生理作用の解析, 武田科学振興財団薬学系研究奨励
Winner: Ishii Isao
 
2005
生体内におけるシステイン生合成経路の役割の解明, 薬学研究奨励財団研究助成
Winner: Ishii Isao
 
2004
システイン生合成酵素(シスタチオニンガンマライエース)の生理的役割の解析, 金原一郎記念医学医療振興財団基礎医学医療研究助成
Winner: Ishii Isao
 
2004
てんかんモデルとしての生理活性脂質スフィンゴシン1リン酸受容体欠損マウスの解析, 精神・神経科学振興財団調査研究助成
Winner: Ishii Isao
 

Published Papers

 
Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H
Endocrinology   157(5) 1839-1851   May 2016   [Refereed]
Klionsky DJ, Ishii I et al
Autophagy   12(1) 1-222   Jan 2016   [Refereed]
Wedmann R, Onderka C, Wei S, Szijártó I, Miljkovic J, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR*
Chemical Science   in press(5) 3414-3426   Feb 2016   [Refereed]
Kamata S, Yamamoto J, Ohtani H, Tosaka Y, Yoshikawa S, Akahoshi N, Ishii I
FEBS open bio   8(9) 1524-1543   Sep 2018   [Refereed]
Ishii I*, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y
J Toxicol Sci   40(6) 837-841   Sep 2015   [Refereed]
Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M
Hypertension (Dallas, Tex. : 1979)   71(6) 1210-1217   Jun 2018   [Refereed]
Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y*
Chem Res Toxicol   28(9) 1796-1802   Aug 2015   [Refereed]
Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, Martinon F, Busso N
The Journal of biological chemistry   293(7) 2546-2557   Feb 2018   [Refereed]
Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE*
Am J Physiol Lung Cell Mol Physiol   309(7) L710-L724   Jul 2015   [Refereed]
Nakashima F, Shibata T, Kamiya K, Yoshitake J, Kikuchi R, Matsushita T, Ishii I, Giménez-Bastida JA, Schneider C, Uchida K
Scientific reports   8(1) 932   Jan 2018   [Refereed]
Kamata S, Akahoshi N, Ishii I*
FEBS Open Bio   5 535-541   Jun 2015   [Refereed]
Kamata S, Ishii I
Methods in molecular biology (Clifton, N.J.)   1664 153-166   2018   [Refereed]
Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I*
FEBS Open Bio   5 357-368   Apr 2015   [Refereed]
Akiyama M, Shinkai Y, Unoki T, Shim I, Ishii I, Kumagai Y
Chemical research in toxicology   30(12) 2209-2217   Dec 2017   [Refereed]
Han SJ, Noh MR, Jung JM, Ishii I, Yoo J, Kim JI, Park KM
Free radical biology & medicine   112 423-432   Nov 2017   [Refereed]
Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K
Nucleic acids research   45(1) 435-445   Jan 2017   [Refereed]
Sarkar S, Ha YS, Soni N, An GI, Lee W, Kim MH, Huynh PT, Ahn H, Bhatt N, Lee YJ, Kim JY, Park KM, Ishii I, Kang SG, Yoo J
Angewandte Chemie (International ed. in English)   55(32) 9365-9370   Aug 2016   [Refereed]
Markó L, Szijártó IA, Filipovic MR, Kaßmann M, Balogh A, Park JK, Przybyl L, N'diaye G, Krämer S, Anders J, Ishii I, Müller DN, Gollasch M
Scientific reports   6 27517   Jun 2016   [Refereed]
Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M
PloS one   11(8) e0160521   2016   [Refereed]
Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y*
Chem Res Toxicol   28(6) 1301-1306   Apr 2015   [Refereed]
Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y*
Chem Res Toxicol   28(5) 838-847   Mar 2015   [Refereed]
Nakano S, Ishii I*, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M
J Mol Med   93(8) 879-889   Feb 2015   [Refereed]
Shinmura K*, Tamaki K, Ito K, Yan X, Yamamoto T, Katsumata Y, Matsuhashi T, Sano M, Fukuda K, Suematsu M, Ishii I
Am J Physiol Heart Circ Physiol   308 H894-H903   Feb 2015   [Refereed]
Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I*
Toxicol Appl Pharmacol   282(2) 195-206   Jan 2015   [Refereed]
Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I*
Am J Physiol Renal Physiol   306(12) F1462-F1476   Jun 2014   [Refereed]
Kamata S, Yamamoto J, Kamijo K, Ochiai T, Morita T, Yoshitomi Y, Hagiya Y, Kubota M, Ohkubo R, Kawaguchi M, Himi T, Kasahara T, Ishii I*
Mol Nutr Food Res   58(6) 1309-1321   May 2014   [Refereed]
Okamoto M, Yamaoka M, Takei M, Ando T, Taniguchi S, Ishii I, Tohya K, Ishizaki T, Niki I, Kimura T*
Biochem Biophys Res Commun   442(3-4) 227-233   Nov 2013   [Refereed]
Ang A, Rivers J, Hedge A, Ishii I, Bhatia M*
Am J Physiol Gastrointest Liver Physiol   305(10) G712-G721   Sep 2013   [Refereed]
Ishii I*, Harada Y, Kasahara T
Front Oncol   2 137   Oct 2012   [Refereed]
Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M,Ishii I*
Free Radic Biol Med   52(9) 1716-1726   Mar 2012   [Refereed]
Morikawa T, Kajimura M*, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH*, Suematsu M*
Proc Natl Acad Sci USA   109(4) 1293-1298   Jan 2012
Harada Y, Ishii I*, Hatake K, Kasahara T
Cancer Lett   319(1) 83-88   Jan 2012   [Refereed]
Akahoshi N, Ishizaki I, Naya M, Maekawa T, Yamazoe S, Horiuchi T, Kajimura M, Ohashi Y, Suematsu M*, Ishii I*
Anal Bioanal Chem   402(5) 1859-1864   Dec 2011   [Refereed]
Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I*
Mol Cell Endocrinol   350(1) 31-38   Nov 2011
Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I*
Epilepsy Behav   22(4) 659-665   Oct 2011   [Refereed]
Ikeda K, Kubo A, Akahoshi N, Yamada H, Miura N, Hishiki T, Nagahata, Y, Matsuura T, Suematsu M, Taguchi R, Ishii I*
Anal Bioanal Chem   400(7) 1853-1863   Feb 2011   [Refereed]
Ishii I*, Akahoshi N, Yamada H, Nakano S, Izumi T, and Suematsu M
J Biol Chem   285(34) 26358–26368   Aug 2010   [Refereed]
Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y*
Cardiovasc Res   85(3) 484-493   Feb 2010   [Refereed]
Imasawa T*, Koike K, Ishii I, Chun J, and Yatomi Y
Biochem Biophys Res Commun   392(2) 207-211   Jan 2010   [Refereed]
Ikeda H*, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y.
J Lipid Res   50(3) 556-564   Mar 2009   [Refereed]
Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, and Ishii I*
Hum Mol Genet   17(13) 1994-2005   2008   [Refereed]
Akahoshi N, Murashima YL, Himi T, Ishizaki Y, and Ishii I*
Neurosci Lett   429(2-3) 136-141   2007   [Refereed]
Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, and Brown JH*
Am J Physiol Heart Circ Physiol   292(6) H2944-2951   2007   [Refereed]
Schicho R, Krueger D, Zeller F, Von Weyhern CW, Frieling T, Kimura H, Ishii I, De Giorgio R, Campi B, and Schemann M*
Gastroenterology   131(5) 1542-1552   2006   [Refereed]
Akahoshi N, Izumi T, Ishizaki Y, and Ishii I*.
Biol Pharm Bull   29(9) 1799-1802   2006   [Refereed]
Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, and Spiegel S*
Mol Cell Biol   25(10) 4237-4249   2005   [Refereed]
Namekata K, Enokido Y, Ishii I, Nagai Y, Harada T, and Kimura H*
J Biol Chem   279(51) 52961-52969   2004   [Refereed]
Ishii I, Fukushima N, Ye X, and Chun J.
Annu Rev Biochem   73 321-354   2004   [Refereed]
Ishii I*, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, and Kimura H
Biochem J   381 113-123   2004   [Refereed]
Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Godecke A, Ishii I, Kleuser B, Schafers M, Fobker M, Zidek W, Assmann G, Chun J, and Levkau B.
J Clin Invest   113(4) 569-581   2004   [Refereed]
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).
Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, and Xu Y.
FASEB J   18(2) 341-343   2004   [Refereed]
Olivera A, Rosenfeldt HM, Bektas M, Wang F, Ishii I, Chun J, Milstien S, and Spiegel S.
J Biol Chem   278(47) 46452-46460   2003   [Refereed]
Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, and Spiegel S.
J Biol Chem   278(41) 40330-40336   2003   [Refereed]
Ye X, Ishii I, Kingsbury MA, and Chun J.
Biochim Biophys Acta   1585(2-3) 108-113   2002   [Refereed]
Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, and Chun J.
Mol Cell Biol   22(19) 6921-6929   2002   [Refereed]
Yang AH, Ishii I, and Chun J.
Biochim Biophys Acta   1582(1-3) 197-203   2002   [Refereed]
Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, and Chun J.
J Biol Chem   277(28) 25152-25159   2002   [Refereed]
Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.
Ishii I* and Chun J
Neuroreport   13(5) 593-596   2002   [Refereed]
Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ, Kingsbury MA, Zhang G, Brown JH, and Chun J.
J Biol Chem   276(36) 33697-33704   2001   [Refereed]
Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda AR, and Chun J.
J Biol Chem   276(18) 15208-15215   2001   [Refereed]
Fukushima N, Ishii I, Contos JJ, Weiner JA, and Chun J.
Annu Rev Pharmacol Toxicol   41 507-534   2001   [Refereed]
Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system.
Ishii I, Contos JJ, Fukushima N, and Chun J.
Mol Pharmacol   58(5) 895-902   2000   [Refereed]
Lysophosphatidic acid receptors.
Contos JJ, Ishii I, and Chun J.
Mol Pharmacol   58(6) 1188-1196   2000   [Refereed]
Chun J, Weiner JA, Fukushima N, Contos JJ, Zhang G, Kimura Y, Dubin A, Ishii I, Hecht JH, Akita C, and Kaushal D.
Ann N Y Acad Sci   905 110-117   2000   [Refereed]
Ishii I, Saito E, Izumi T, Ui M, and Shimizu T.
J Biol Chem   273(16) 9878-9885   1998   [Refereed]
High and low affinity mutants of platelet-activating factor receptor.
Ishii I, Izumi T, Ui M, and Shimizu T.
Adv Exp Med Biol   433 249-253   1997   [Refereed]
Ishii I, Izumi T, Tsukamoto H, Umeyama H, Ui M, and Shimizu T*
J Biol Chem   272(12) 7846-7854   1997   [Refereed]

Books etc

 
RSSの生合成系とタンパク質機能制御
渡邉 泰男, 石井 功, 蕨 栄治 (Part:Joint Work, 372-376)
学研メディカル秀潤社   Mar 2015   
ホモシステイン血症再考
石井 功*.
日本生化学会   Dec 2013   
Methionine: Biosynthesis, Chemical Structure and Toxicity.
Shotaro Kamata, Ishii Isao (Part:Joint Work, 143-153)
Nova Science Publishers, Inc.   Jul 2013   ISBN:978-1-62618-246-2
システイン生合成経路の破綻による病態
石井 功, 赤星 軌征 (Part:Joint Work)
日本アミノ酸学会   2007   
分子栄養学の基礎
石井 功
第一出版   2006   

Conference Activities & Talks

 
心虚血再灌流障害におけるホモシステインの新規作用機序
石井 功、中埜 信太郎、新村 健、玉城 香代子、菱木 貴子、赤星 軌征、井田 智章、中西 豪、鎌田 祥太郎、熊谷 嘉人、赤池 孝章、福田 恵一、佐野 元昭、末松 誠
第38回日本分子生物学会年会・第88回日本生化学会大会合同年会   4 Dec 2015   
絶食によるマウス臓器タンパク質リモデリングの網羅的プロテオーム解析
鎌田 祥太郎、山本 隼也、海沼 亮、大谷 遥香、戸坂 優花、笠原 忠、石井 功
第38回日本分子生物学会年会・第88回日本生化学会大会合同年会   2 Dec 2015   
Cytathionine β synthase is required to maintain glutathione hydropersulfide, a novel antioxidant molecule, in the murine lens
Yoshioka T, Goto S, Okuda Y, Kubo A, Ishii Isao, Hishiki T, Yamamoto T, Takano N, Hoshino T, Nakamura T, Nagaoka T, Yoshida A, Suematsu M, Kajimura M
10th World Congress for Microcirculation   25 Sep 2015   
食餌誘導性高ホモシステイン血症感受性マウスの解析
戸坂 優花、大谷 遥香、三浦 あす美、長田 知子、鎌田 祥太郎、石井 功
第59回日本薬学会関東支部大会   12 Sep 2015   
短期絶食によるマウス全身性応答2(臓器別タンパク質発現変化)
大谷 遥香、山本 隼也、戸坂 優花、鎌田 祥太郎、石井 功
第59回日本薬学会関東支部大会   12 Sep 2015