J-GLOBAL         Last updated: Jan 15, 2019 at 00:28
Kindai University
Faculty of Medicine
Job title
MD, PhD(Kyoto University)


Makoto Hosono, MD, PhD, is Professor of Institute of Advanced Clinical Medicine and Department of Radiology, Kindai University, Osaka, Japan, and serves as a member of ICRP C3 since 2017. After graduating from Kyoto University School of Medicine, Japan, he has been contributing to the fields including nuclear oncology, tumor targeting, and radiation protection as well as neurology and cardiology. He serves as the Chair of PET Committee since 2011 and as an active member of Radionuclide Therapy Committee of Japanese Society of Nuclear Medicine (JSNM). He also served as the Chief of Working Group for establishment of National Diagnostic Reference Levels in 2015 (Japan DRLs 2015) for diagnostic radiology and nuclear medicine by organizing cooperation among radiology-related academic and professional organizations in the framework of Japan Network for Research and Information on Medical Exposure (J-RIME). Since 2017, he is the Chief of J-RIME. He has been the principal Investigator of a Research Group on Radiation Protection in Medicine of Ministry of Health in Japan since 2007. He was responsible for the clinical trials of Ra-223 dichloride in Japan as one of principal investigators since 2011. He has participated in numerous educational activities for PET and SPECT oncology imaging and radionuclide therapy at national and international events.

Research Areas


Academic & Professional Experience

Oct 2005
Professor, Department of Radiology, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine
Apr 2003
Sep 2005
Associate Professor, Department of Radiology, Kindai University Faculty of Medicine
Oct 1995
Apr 2003
Lecturer, Department of Radiology, Saitama Medical University
Oct 1994
Sep 1995
Research Fellow, INSERM U211, Nantes University, French Government Research Fellowship
Oct 1993
Sep 1994
Humboldt Foundation Research Fellow, Bonn University Department of Nuclear Medicine, Humboldt Foundation Research Fellowship
Apr 1993
Sep 1993
Fellow, Department of Radiology and Nuclear Medicine, Kyoto University Hospital
Apr 1986
Mar 1989
Fellow, Department of Radiology, Kitano Hospital (Osaka)
Apr 1985
Mar 1986
Resident, Department of Radiology and Nuclear Medicine, Kyoto University Hospital


Apr 1989
Mar 1993
Radiology and Nuclear Medicine, Internal Medicine System, Kyoto University Graduate School of Medicine
Apr 1979
Mar 1985
Kyoto University Faculty of Medicine

Committee Memberships

Oct 2017
The Humboldt Association of Japan  Kansai Chapter Board Member
Jul 2017
ICRP C3  Member
Apr 2017
Japan Network for Research and Information in Medical Exposure  Chair
Jul 2016
Japan Neuroendocrine Tumor Society  Board Member
Jul 2016
Japan Neuroendocrine Tumor Society  Chair, Nuclear Medicine Committee
Apr 2016
Japan Radioisotope Association  Chair, Radionuclide Therapy Committee
Oct 2011
Japanese Society of Nuclear Medicine  Chair, PET Committee
Oct 2011
Japanese Society of Nuclear Medicine  Board Member
Apr 2006
Japan Radiological Society  Member, Representative Assembly

Awards & Honors

Oct 2009
48th Japanese Society of Nuclear Medicine Award, Japanese Society of Nuclear Medicine
Oct 1997
Award, Atomic Energy Research Foundation in Medicine, Atomic Energy Research Foundation in Medicine

Published Papers

Three year follow up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases
Uemura H, Uemura H, Nagamori S, Wakumoto Y, Kimura G, Kikukawa H, Yokomizo A, Mizokami A, Kosaka T, Masumori N, Kawasaki Y, Yonese J, Nasu Y Fukasawa S, Sugiyama T, Kinuya S, Hosono M, Yamaguchi I, Akagawa T, Matsubara N
Int J Clin Oncol   in press    2019   [Refereed]
Hosono M, Ikebuchi H, Nakamura Y, Yanagida S, Kinuya S
Annals of Nuclear Medicine   in press    2018   [Refereed]
Hayashi S, Takenaka M, Hosono M, Nishida T
World Journal of Clinical Cases   6(16) 1087-1093   2018   [Refereed][Invited]
International Journal of Radiation Biology   in press    2018   [Refereed][Invited]
Radiation Effects Association   10(97) 21-22   Oct 2018   [Invited]
Yukie Yoshii1, Mitsuyoshi Yoshimoto, Tatsuya Higashi, Makoto Hosono
Kakuigaku   55(1) 77-87   Jul 2018   [Refereed]
Watanabe Shota, Sakaguchi Kenta, Hosono Makoto, Ishii Kazunari, Murakami Takamichi, Ichikawa Katsuhiro
Japanese Journal of Radiological Technology   74(4) 375-381   Apr 2018
HOSONO Makoto, CHATAL Jean-François
Resistance to Targeted Anti-Cancer Therapeutics   1-158   Apr 2018   [Refereed][Invited]
Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yamada T, Yanagida S, Kitaoka A, Kojima K, Sugano H, Kinuya S, Inoue T, Hatazawa J
Annals of Nuclear Medicine   32(3) 217-235   Apr 2018   [Refereed][Invited]
Tachibana I, Nishimura Y, Hanaoka K, Inada M, Fukuda K, Tatebe H, Ishikawa K, Nakamatsu K, Kanamori S, Hosono M
Anticancer research   38(3) 1775-1781   Mar 2018   [Refereed]

Books etc

Heterogeneity of intratumoral antibody distribution
HANAOKA Kohei, HOSONO Makoto (Part:Joint Work)
Springer International Publishing   Apr 2018   ISBN:978-3-319-78237-9
Features of ibritumomab as radionuclide therapy. Resistance to ibritumomab in lymphoma
HOSONO Makoto (Part:Joint Work, Resistance to ibritumomab in lymphoma)
Springer International Publishing   Apr 2018   ISBN:978-3-319-78238-6
Gamut of FDG-PET
HOSONO Makoto (Part:Joint Work)
JSNM   Oct 2012   
Safety and Efficient Use of Radiation in Medicine
HOSONO Makoto (Part:Joint Work, Comprehensive Report)
Mar 2012   
Comparison of functions of CT, MRI, and PET
Oct 2005   

Conference Activities & Talks

Nuclear Medicine in Oncology [Invited]
62nd Meeting of Fukuoka RI Conference   27 Oct 2018   Fukuoka RI Conference
Domestic Situations of Nuclear Medicine Therapy and Future Prospects [Invited]
56th Annual Meeting of Japanese Society of Clinical Oncology   19 Oct 2018   Japanese Society of Clinical Oncology
Radionuclide Therapy [Invited]
31st Annual Meeting of Japanese Society of Radiation Oncology   11 Oct 2018   Japanese Society of Radiation Oncology
Interpretation and determination of images [Invited]
36th Safety handling course of radioimmunotherapy using Yttrium-90 labeled anti-CD20 antibody   29 Sep 2018   
Significance and application of diagnostic reference levels in ICRP recommendation (Explanation of Pub.135) [Invited]
Course held by Radiation Effect Association (ICRP Seminar)   26 Sep 2018   
Medical use and reasonable safety management of radionuclides (including alpha emitting radionuclides) [Invited]
平成30年度秋期放射線安全管理研修会 放射線障害防止中央協議会   20 Sep 2018   
Radiological Protection for Innovative Targeted Therapy [Invited]
Annual Meeting of Society of Nuclear Medicine and Molecular Imaging 2018   26 Jun 2018   Society of Nuclear Medicine and Molecular Imaging
Effectiveness of targeted alpha therapy [Invited]
14th Workshop on safety handling of Ra-223   26 May 2018   
Guidelines in radionuclide therapy [Invited]
!8th Spring Meeting of JSNM   13 May 2018   
Perspectives of radionuclide therapy [Invited]
18th Spring Meeting of JSNM   12 May 2018   

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2012    Investigator(s): Makoto HOSONO
In patients with CD20 positive B-cell non-Hodgkin lymphoma who underwent yttrium-90 labeled anti-CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes wer...
Grant-in-Aid for Scientific Research
Project Year: 2003 - 2006
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2006    Investigator(s): Makoto HOSONO
Molecular targeting concept and technology have recently been established and applied to disease entities, and have proved efficient and indispensable in some pathological status. As one of molecular targeting applications, radioimmunoscintigraphy...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2002    Investigator(s): Makoto HOSONO
The "affinity enhancement system", a two-step targeting technique using bispecific antibody and radiolabeled bivalent hapten, has been reported to be useful for the targeting of carcinoembryonic antigen-expressing tumors. The purpose of this study...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 2001    Investigator(s): Kikuo MACHIDA
Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality enabling differential diagnosis of dementia. The purpose was to measure inter-obserYer variations in diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Kikuo MACHIDA
Fifteen-four studies of ^<20l>T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-obser...