J-GLOBAL         Last updated: May 16, 2019 at 10:50
Kindai University
Faculty of Medicine
Job title
MD, PhD(Kyoto University)


Makoto Hosono, MD, PhD, is Professor of Department of Radiology and Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Osaka, Japan, and serves as a member of ICRP C3 since 2017. After graduating from Kyoto University School of Medicine, Japan, he has been contributing to the fields including nuclear oncology, tumor targeting, and radiation protection as well as neurology and cardiology. He serves as the Chair of PET Committee since 2011 and as an active member of Radionuclide Therapy Committee of Japanese Society of Nuclear Medicine (JSNM). He also served as the Chief of Working Group for establishment of National Diagnostic Reference Levels in 2015 (Japan DRLs 2015) for diagnostic radiology and nuclear medicine by organizing cooperation among radiology-related academic and professional organizations in the framework of Japan Network for Research and Information on Medical Exposure (J-RIME). Since 2017, he is the Chair of J-RIME. He has been the principal Investigator of a Research Group on Radiation Protection in Medicine of Ministry of Health in Japan since 2007. He was responsible for the clinical trials of Ra-223 dichloride in Japan as one of principal investigators since 2011. He has participated in numerous educational activities for PET and SPECT oncology imaging and radionuclide therapy at national and international events.

Research Areas


Academic & Professional Experience

Oct 2005
Professor, Department of Radiology, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine
Apr 2003
Sep 2005
Associate Professor, Department of Radiology, Kindai University Faculty of Medicine
Oct 1995
Apr 2003
Lecturer, Department of Radiology, Saitama Medical University
Oct 1994
Sep 1995
Research Fellow, INSERM U211, Nantes University, French Government Research Fellowship
Oct 1993
Sep 1994
Humboldt Foundation Research Fellow, Bonn University Department of Nuclear Medicine, Humboldt Foundation Research Fellowship
Apr 1993
Sep 1993
Fellow, Department of Radiology and Nuclear Medicine, Kyoto University Hospital
Apr 1986
Mar 1989
Fellow, Department of Radiology, Kitano Hospital (Osaka)
Apr 1985
Mar 1986
Resident, Department of Radiology and Nuclear Medicine, Kyoto University Hospital


Apr 1989
Mar 1993
Radiology and Nuclear Medicine, Internal Medicine System, Kyoto University Graduate School of Medicine
Apr 1979
Mar 1985
Kyoto University Faculty of Medicine

Committee Memberships

Oct 2017
The Humboldt Association of Japan  Kansai Chapter Board Member
Jul 2017
ICRP C3  Member
Apr 2017
Japan Network for Research and Information in Medical Exposure  Chair
Jul 2016
Japan Neuroendocrine Tumor Society  Chair, Nuclear Medicine Committee
Jul 2016
Japan Neuroendocrine Tumor Society  Board Member
Apr 2016
Japan Radioisotope Association  Chair, Radionuclide Therapy Committee
Oct 2011
Japanese Society of Nuclear Medicine  Board Member
Oct 2011
Japanese Society of Nuclear Medicine  Chair, PET Committee
Apr 2006
Japan Radiological Society  Member, Representative Assembly

Awards & Honors

Oct 2009
48th Japanese Society of Nuclear Medicine Award, Japanese Society of Nuclear Medicine
Oct 1997
Award, Atomic Energy Research Foundation in Medicine, Atomic Energy Research Foundation in Medicine

Published Papers

Rapid progression of metastatic pulmonary calcification diagnosed by 99mTc-MDP scintigraphy
Fukumoto G, Hosono M, Kanagaki M, Otani T, Ikegaki S.
Japanese Archive of Cases Conference of Clinical Nuclear Medicine   1(3) 17-22   May 2019   [Refereed]
Projects for revision of DRLs in nuclear medicine and prospects
Innervision   34(3) 32-33   Mar 2019   [Invited]
Otani T, Hosono M, Kanagaki M, Oka S, Fukumoto G, Onishi Y, Matsubara N, Kawabata K, Kimura H.
American J Roentgenology   in press    2019   [Refereed]
Nuclear Medicine and Molecular Imaging   in press    2019   [Refereed][Invited]
Uemura H, Uemura H, Nagamori S, Wakumoto Y, Kimura G, Kikukawa H, Yokomizo A, Mizokami A, Kosaka T, Masumori N, Kawasaki Y, Yonese J, Nasu Y Fukasawa S, Sugiyama T, Kinuya S, Hosono M, Yamaguchi I, Akagawa T, Matsubara N
Int J Clin Oncol   2019(5) 557-566   May 2019   [Refereed]
Hosono M, Ikebuchi H, Nakamura Y, Yanagida S, Kinuya S
Annals of Nuclear Medicine   in press    2019   [Refereed]
International Journal of Radiation Biology   in press    2019   [Refereed][Invited]
Hayashi S, Takenaka M, Hosono M, Nishida T
World Journal of Clinical Cases   6(16) 1087-1093   2018   [Refereed][Invited]
Radiation Effects Association   10(97) 21-22   Oct 2018   [Invited]
Yukie Yoshii, Mitsuyoshi Yoshimoto, Tatsuya Higashi, Makoto Hosono
Kakuigaku   55(1) 77-87   Jul 2018   [Refereed]

Books etc

Heterogeneity of intratumoral antibody distribution
HANAOKA Kohei, HOSONO Makoto (Part:Joint Work)
Springer International Publishing   Apr 2018   ISBN:978-3-319-78237-9
Features of ibritumomab as radionuclide therapy. Resistance to ibritumomab in lymphoma
HOSONO Makoto (Part:Joint Work, Resistance to ibritumomab in lymphoma)
Springer International Publishing   Apr 2018   ISBN:978-3-319-78238-6
Gamut of FDG-PET
HOSONO Makoto (Part:Joint Work)
JSNM   Oct 2012   
Safety and Efficient Use of Radiation in Medicine
HOSONO Makoto (Part:Joint Work, Comprehensive Report)
Mar 2012   
Comparison of functions of CT, MRI, and PET
Oct 2005   

Conference Activities & Talks

Radiation protection standards in novel radionuclide therapy [Invited]
The 13th Asia Oceania Congress of Nuclear Medicine and Biology   10 May 2019   Asia Oceania Federation of Nuclear Medicine and Biology
ICRP perspectives for individualized radionuclide therapy [Invited]
Theranostics World Congress 2019 (TWC2019)   2 Mar 2019   
Radiation protection for patients and practitioner in fluoroscopy-guided procedures [Invited]
9th Meeting of FIGHT-Japan   24 Feb 2019   
Contribution to PET and RNT as Pharmacist [Invited]
ASAMI Keita, HOSONO Makoto, et al.
Japanese Society of Hospital Pharmacists   20 Jan 2019   
ICRP C3 [Invited]
Radiation Effect Association   26 Dec 2018   
Management of radiation control in short-lived radionuclides including alpha emitters [Invited]
Japanese Society of Radiation Safety Management   6 Dec 2018   
Nuclear Medicine in Oncology [Invited]
62nd Meeting of Fukuoka RI Conference   27 Oct 2018   Fukuoka RI Conference
Domestic Situations of Nuclear Medicine Therapy and Future Prospects [Invited]
56th Annual Meeting of Japanese Society of Clinical Oncology   19 Oct 2018   Japanese Society of Clinical Oncology
Radionuclide Therapy [Invited]
31st Annual Meeting of Japanese Society of Radiation Oncology   11 Oct 2018   Japanese Society of Radiation Oncology
Interpretation and determination of images [Invited]
36th Safety handling course of radioimmunotherapy using Yttrium-90 labeled anti-CD20 antibody   29 Sep 2018   

Research Grants & Projects

Research on standards for radiation protection in conventional and innovative radiological practices
Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: Apr 2019 - Mar 2022    Investigator(s): HOSONO Makoto
Dosimetry and personalized therapy in radionuclide therapy using novel nuclides
Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2018 - Mar 2021    Investigator(s): HOSONO Makoto
Research on reasonable radiation management for short-lived alpha emitters
Nuclear Regulatory Agency: Project for promotion of radiation safety regulations
Project Year: Apr 2017 - Mar 2019    Investigator(s): HOSONO Makoto
Research on radiation protection for novel therapeutic procedures
Ministry of Health, Labour and Welfare: Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants
Project Year: Apr 2016 - Mar 2019    Investigator(s): HOSONO Makoto
Ministry of Education,Culuture,Sports,Science and Technology: Grant-in-Aid for Scientific Research
Project Year: Apr 2013 - Mar 2017    Investigator(s): HOSONO Makoto
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2012    Investigator(s): Makoto HOSONO
In patients with CD20 positive B-cell non-Hodgkin lymphoma who underwent yttrium-90 labeled anti-CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes wer...
Grant-in-Aid for Scientific Research
Project Year: 2003 - 2006
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2006    Investigator(s): Makoto HOSONO
Molecular targeting concept and technology have recently been established and applied to disease entities, and have proved efficient and indispensable in some pathological status. As one of molecular targeting applications, radioimmunoscintigraphy...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2002    Investigator(s): Makoto HOSONO
The "affinity enhancement system", a two-step targeting technique using bispecific antibody and radiolabeled bivalent hapten, has been reported to be useful for the targeting of carcinoembryonic antigen-expressing tumors. The purpose of this study...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 2001    Investigator(s): Kikuo MACHIDA
Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality enabling differential diagnosis of dementia. The purpose was to measure inter-obserYer variations in diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 ...