2016年11月15日
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program
Genes and Development
- 巻
- 30
- 号
- 22
- 開始ページ
- 2475
- 終了ページ
- 2485
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1101/gad.290593.116
- 出版者・発行元
- Cold Spring Harbor Laboratory Press
In general, cell fate is determined primarily by transcription factors, followed by epigenetic mechanisms fixing the status. While the importance of transcription factors controlling cell fate has been well characterized, epigenetic regulation of cell fate maintenance remains to be elucidated. Here we provide an obvious fate conversion case, in which the inactivation of polycomb-medicated epigenetic regulation results in conversion of T-lineage progenitors to the B-cell fate. In T-cell-specific Ring1A/B-deficient mice, T-cell development was severely blocked at an immature stage. We found that these developmentally arrested T-cell precursors gave rise to functional B cells upon transfer to immunodeficient mice. We further demonstrated that the arrest was almost completely canceled by additional deletion of Pax5. These results indicate that the maintenance of T-cell fate critically requires epigenetic suppression of the B-lineage gene program.
- ID情報
-
- DOI : 10.1101/gad.290593.116
- ISSN : 1549-5477
- ISSN : 0890-9369
- PubMed ID : 27913604
- SCOPUS ID : 85005942732