2016年1月1日
Generation and regeneration of T cells
Synthetic Immunology
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- 開始ページ
- 31
- 終了ページ
- 56
- 記述言語
- 英語
- 掲載種別
- 論文集(書籍)内論文
- DOI
- 10.1007/978-4-431-56027-2_2
- 出版者・発行元
- Springer Japan
T cells contain a variety of lineages, each of which is formed by passing through a number of strictly regulated steps. In this article we aim to clarify essential factors and critical developmental steps during T cell development. First, we will describe the process of T cell development that occurs in vivo. Then, by presenting recent approaches in synthetic biology, we will show that, in the murine case, a feeder-free culture system using a combination of cytokines and Notch ligand is sufficient to support T cell development starting from multipotent hematopoietic progenitors to the TCR-expressing CD4+CD8+ stage. Finally, in the human case, we will show that mature functional CD8+ killer T cells can be produced in vitro starting as early as from the ES/iPS cell stage using feeder cells. These studies may help clarify “minimal requirements” for T cell development.
- ID情報
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- DOI : 10.1007/978-4-431-56027-2_2
- SCOPUS ID : 85018927320