論文

査読有り
2018年6月1日

Double helix formation from non-natural amylose analog polysaccharides

Carbohydrate Polymers
  • Toshifumi Yui
  • ,
  • Takuya Uto
  • ,
  • Takuya Nakauchida
  • ,
  • Kazuya Yamamoto
  • ,
  • Jun ichi Kadokawa

189
開始ページ
184
終了ページ
189
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.carbpol.2018.02.026

© 2018 Elsevier Ltd Double helix formation from the non-natural anionic and cationic amylose analog polysaccharides (amylouronic acid and amylosamine, respectively) was achieved through electrostatic interactions. A water-insoluble complex was obtained by simply mixing the two polysaccharides in water. The 1H NMR analysis indicated that the formation of the complexes with an approximately equimolar unit ratio from the two polysaccharides was resulted regardless of feed ratios for mixing. The powder X-ray diffraction (XRD) measurement suggested that the helix had larger sizes both in diameter and pitch compared with well-known amylose double helix. The formation of the double helical structure was also examined by theoretical calculations. The double helix models, differing in a chain polarity and a charge state of the residues, were constructed based on the 6-fold left-handed amylose chain of the A-amylose crystal structure. Molecular dynamics calculations indicated that those with an antiparallel chain polarity retained an intertwined form. The antiparallel double helical model with the free form residues was suggested to be the most likely structure for the non-natural polysaccharides.

リンク情報
DOI
https://doi.org/10.1016/j.carbpol.2018.02.026
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29580397
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042209189&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85042209189&origin=inward
ID情報
  • DOI : 10.1016/j.carbpol.2018.02.026
  • ISSN : 0144-8617
  • PubMed ID : 29580397
  • SCOPUS ID : 85042209189

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