Exchange protein directly activated by cAMP (EPAC) promotes transcriptional activation of the decidual prolactin gene via CCAAT/enhancer-binding protein in human endometrial stromal cells.
Kusama K, Tamura K, Bai H, Sakurai T, Nishi H, Isaka K, Imakawa K, Yoshie M.
In this study, we demonstrated that cAMP-mediated Epac/Rap1 signaling pathway may regulate trophoblast cell differentiation and syncytialization and endometrial stromal cell decidualization which are crucial for human placentation.
Involvement of exchange protein directly activated by cAMP (Epac) in placentation.
