2007年12月
Hydrodynamic gene delivery: Its principles and applications
MOLECULAR THERAPY
- ,
- 巻
- 15
- 号
- 12
- 開始ページ
- 2063
- 終了ページ
- 2069
- 記述言語
- 英語
- 掲載種別
- 書評論文,書評,文献紹介等
- DOI
- 10.1038/sj.mt.6300314
- 出版者・発行元
- NATURE PUBLISHING GROUP
Efficient and safe methods for delivering genetic materials into cells must be developed before the clinical potential of gene therapy can be fully realized. Recently, hydrodynamic gene delivery using a rapid injection of a relatively large volume of DNA solution has opened up a new avenue for gene therapy studies in vivo. This method is superior to the existing delivery systems because of its simplicity, efficiency, and versatility. Wide success in applying hydrodynamic principles to delivery of DNA, RNA, proteins, and synthetic compounds, into the cells in various tissues of small animals, has inspired the recent attempts at establishing a hydrodynamic procedure for clinical use. In this review, we provide an overview of the theory and practice of hydrodynamic gene delivery so as to aid researchers for the use of this method in their pre-clinical and translational gene therapy studies.
- リンク情報
- ID情報
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- DOI : 10.1038/sj.mt.6300314
- ISSN : 1525-0016
- Web of Science ID : WOS:000251266800004