論文

査読有り
2007年11月

Fucosylated fraction of alpha-fetoprotein, L3, as a useful prognostic factor in patients with hepatocellular carcinoma with special reference to low concentrations of serum alpha-fetoprotein

HEPATOLOGY RESEARCH
  • Makoto Kobayashi
  • ,
  • Takashi Kuroiwa
  • ,
  • Takeshi Suda
  • ,
  • Yasushi Tamura
  • ,
  • Hirokazu Kawai
  • ,
  • Masato Igarashi
  • ,
  • Yasuo Fukuhara
  • ,
  • Yutaka Aoyagi

37
11
開始ページ
914
終了ページ
922
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1872-034X.2007.00147.x
出版者・発行元
BLACKWELL PUBLISHING

Background: The aim of the present study was to establish L3 fraction before initial treatment as a useful prognostic factor in a prospective fashion in hepatocellular carcinoma (HCC) where the alpha-fetoprotein (AFP) was very low.
Methods: From 1990 to 2004, 298 HCC patients in whom L3 could be measured were examined in the present study. Enrolled patients with HCC underwent operation, transcatheter arterial chemoembolization and percutaneous ablation therapy. The current patient status was confirmed as of the end of March 2005. L3 was determined by crossed immuno-affinoelectrophoresis when AFP was >= 30 ng/mL. It was carried out by liquid-phase binding assay system on cases where AFP < 30 ng/mL. The tentative discriminating line of L3 was set at 15%.
Results: The HCC group included four subgroups: 110 patients with AFP concentrations <= 100 ng/mL, 70 with AFP <= 50 ng/mL, 38 with AFP <= 30 ng/mL and 29 with AFP <= 25 ng/mL. The mean survival rate in the HCC group, whose L3 was > 15% (high L3), was significantly lower than that in the HCC group whose L3 was <= 15% (low L3). There were also statistically significant differences in survival rates between high and low L3 in the four HCC subgroups. The statistically significant differences were more distinct in the subgroups with low AFP concentrations.
Conclusion: The present study indicates that the L3 fraction before treatment serves as a useful prognostic indicator when the serum concentrations of AFP were very low.

リンク情報
DOI
https://doi.org/10.1111/j.1872-034X.2007.00147.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249486200004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1872-034X.2007.00147.x
  • ISSN : 1386-6346
  • Web of Science ID : WOS:000249486200004

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