J-GLOBAL         Last updated: May 27, 2019 at 15:55
Nagasaki University
Graduate School of Biomedical Sciences, Medical and Dental Sciences
Job title
Assistant Professor
Ph.D(Nagasaki University)

Research Interests


Research Areas



Graduate School, Division of Dental Research, Nagasaki University
Faculty of Dentistry, Nagasaki University

Published Papers

Kuba S, Fujiyama R, Yamanouchi K, Morita M, Sakimura C, Hatachi T, Matsumoto M, Yano H, Takatsuki M, Hayashida N, Nagayasu T, Eguchi S.
Supportive Care in Cancer   26(11) 3883-3889   2018   [Refereed]
Rie Fujiyama, Kazuo Toda
Odontology   105(3) 275-282   Jul 2017   [Refereed]
© 2016 The Society of The Nippon Dental UniversityThermal modulation of signaling pathways leads to excitation of taste receptor cells, but the underlying mechanisms remain unclear. Furthermore, it has long been known that there are contrast effec...
Yukio Okada, Toshihiro Miyazaki, Rie Fujiyama, Kazuo Toda
Biochemistry and Biophysics Reports   4 175-179   Dec 2015
© 2015 The Authors.The rod cells in frog taste discs display the outward current and maintain the negative resting potential in the condition where internal K+ is replaced with Cs+. We analyzed the properties of the Cs+-permeable conductance in th...
Yukio Okada, Toshihiro Miyazaki, Rie Fujiyama, Kazuo Toda
Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology   166 434-440   Nov 2013
The effects of unsaturated fatty acids on membrane properties were studied using conventional whole-cell patch-clamp recording of isolated wing (Ib) cells in bullfrog (Lithobates catesbeianus) taste discs. Applying arachidonic acid to the bath ind...
1. Okada Y, Imendra KG, Miyazaki T, Hotokezaka H, Fujiyama R, Toda K
PLoS One   6(4)    2011   [Refereed]
Rie Fujiyama, Shingo Ishitobi, Keiko Honda, Yukio Okada, Kumiko Oi, Kazuo Toda
Odontology   98(1) 82-84   2010
Y Okada, KG Imendra, T Miyamoto, H Hotokezaka, R Fujiyama, JL Zeredo, K Toda
Cellular and Molecular Neurobiology   27(6) 771-781   2007
Toda K. Zeredo JL.Fujiyama R. Okada Y. and Nasution,FH
Brain Res. Bull   62 345-349   2004
Differential transduction mechanisms under lying NaCl-and KCl-induced responses in mouse taste cells
26(1) 67-77   2001
Non-synaptic transformation of gustatory receptor potential by stimulation of the parasympathetic fiber of the frog
26(1) 79-84   2001
Takashi Fukasawa, Takashi Kumazawa, Takenori Miyamoto, Rie Fujiyama, Yukio Okada, Toshihide Sato
Zoological Science   18(3) 299-307   2001
Comparison of a Ca2+-gated conductance and a second-messenger-gated conductance in rat Oltactory neurons
203(3) 567-573   2000
The origin of slow potentials on the tongue surface induced by frog glossopharyngeal efferent fiber stimulation
25(5) 583-589   2000
Sour transduction involves activation of NPPB-Sensitive Conductance in mouse taste cells
80(4) 1852-1859   1998

Conference Activities & Talks

Generation mechanism of the response elicited by calcimimetic R-467 in frog taste cells
Effects of anti-inflammatory drugs on nociceptive responses in rat's temporomandibular joint
Modulation of taste sensitivity following cold stimuli.
Comparison between PROP and four basic taste sensitivities.
Study of a clinical examination for dysgeusia.

Research Grants & Projects

Mechanisms of dysgeusia induced by taste receptor dysfunction
Project Year: Apr 2018 - Mar 2021
Examination of the taste disorder associated with cancer chemotherapy in rats and humans.
Project Year: Apr 2013 - Mar 2016
Study of clinical examination for dysgeusia.
Project Year: Apr 2009 - Mar 2012
DAG lipase-lipoxygenase pathway in Ca sensing of parathyroid cells
Project Year: Apr 2008 - Mar 2011
Integrative mechanisms for protopathic sensation including pain and g ravitropism
Project Year: Apr 2006 - Mar 2008    Investigator(s): Toda Kazuo