A new response: A new type of hybridization switch-free ON-eRS (eukaryotic upregulating riboswitch) activates ribosomal shunting in response to a ligand. Whereas the ribosome that has finished sORF translation scans the 5′-side strand of the aptamer and stops at the rigid stem in the absence of the ligand, it shunts over the stem bearing the aptamer-ligand complex and then reinitiates translation of dORF in the presence of the ligand. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.