ITOH Hiroshi

Last updated: Jan 12, 2019 at 01:21

Name	ITOH Hiroshi
E-mail	h_itohnagahama-i-bio.ac.jp
Affiliation	Kyoto University
Section	Graduate School of MedicineHuman Health Sciences
Job title	Assistant Professor,Assistant Professor
Research funding number	20362387

Research Interests

neutrophil(21) , purines(2)

Research Areas

Clinical internal medicine / Hematology /
Basic medicine / Immunology /
Clinical internal medicine / Infectious disease medicine /
Boundary medicine / Laboratory medicine /
Clinical internal medicine / Collagenous pathology/Allergology /

Academic & Professional Experience

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2016

Today

associate professor, Nagahama Institute of Bio-Science and Technology

Published Papers

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Establishment of S100A8 Transgenic Rats to Understand Innate Property of S100A8 and Its Immunological Role.

Okada K, Itoh H, Kamikubo Y, Adachi S, Ikemoto M

Inflammation 41(1) 59-72 Feb 2018 [Refereed]

CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions.

Okada K, Arai S, Itoh H, Adachi S, Hayashida M, Nakase H, Ikemoto M

Journal of leukocyte biology 100(5) 1093-1104 Nov 2016 [Refereed]

CXCR4 Overexpression is a Poor Prognostic Factor in Pediatric Acute Myeloid Leukemia With Low Risk: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group.

Matsuo H, Nakamura N, Tomizawa D, Saito AM, Kiyokawa N, Horibe K, Nishinaka-Arai Y, Tokumasu M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Tanaka S, Adachi S

Pediatric blood & cancer 63(8) 1394-1399 Aug 2016 [Refereed]

Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.

Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S.

Leukemia 29(12) 2438-2441 Dec 2015 [Refereed]

Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.

Matsuo H, Itoh H, Kitamura N, Kamikubo Y, Higuchi T, Shiga S, Ichiyama S, Kondo T, Takaori-Kondo A, Adachi S

Biochemical and biophysical research communications 464(1) 94-99 Aug 2015 [Refereed]

Enhancement of neutrophil autophagy by an IVIG preparation against multidrug-resistant bacteria as well as drug-sensitive strains.

Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, Kamikubo Y, Kondo T, Yamashita K, Sasada M, Takaori-Kondo A, Adachi S

Journal of leukocyte biology 98(1) 107-117 Jul 2015 [Refereed]

Autocrine pathways involving S100A8 and/or S100A9 that are postulated to regulate the immunological functions of macrophages in rats.

Okada K, Arai S, Nakase H, Kohno H, Nakamura F, Takeda M, Toda Y, Itoh H, Adachi S, Ikemoto M

Biochemical and biophysical research communications 456(1) 415-420 Jan 2015 [Refereed]

EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.

Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Shiba N, Ohki K, Hayashi Y, Yamashita Y, Shimada A, Tanaka S, Adachi S

Haematologica 99(11) e225-7 Nov 2014 [Refereed]

Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.

Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Tanaka S, Adachi S.

Blood Cancer J e226 Jul 2014 [Refereed]

Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: A variety of functional roles of the two proteins as regulators in acute inflammatory reaction

A. Koike; S. Arai; S. Yamada; A. Nagae; N. Saita; H. Itoh; S. Uemoto; M. Totani; M. Ikemoto

Inflammation 35(2) 409-419 Apr 2012 [Refereed]

Identification of serum proteins that bind with S100A8, S100A9 and S100A8/A9: Clinical significance of using proteins for monitoring the postoperative condition of liver recipients

T. Namura; S. Arai; K. Okawa; A. Koike; S. Yamada; N. Saita; A. Nagae; H. Itoh; M. Totani; S. Uemoto; M. Ikemoto

Clinica Chimica Acta 411(21-22) 1766-1773 Nov 2010 [Refereed]

Ozone production by amino acids contributes to killing of bacteria

K. Yamashita; T. Miyoshi; T. Arai; N. Endo; H. Itoh; K. Makino; K. Mizugishi; T. Uchiyama; M. Sasad

Proceedings of the National Academy of Sciences of the United States of America 105(44) 16912-16917 Nov 2008 [Refereed]

A case with transient increases in serum S100A8/A9 levels implying acute inflammatory responses after pancreatic islet transplantation

M. Ikemoto; S. Matsumoto; H. Egawa; T. Okitsu; Y. Iwanaga; S. Umemoto; H. Itoh; H. Murayama; M. Fujita

Annals of Clinical Biochemistry 44(Pt 6) 570-572 Nov 2007 [Refereed]

Intrinsic function of S100A8/A9 complex as an anti-inflammatory protein in liver injury induced by lipopolysaccharide in rats

M. Ikemoto; H. Murayama; H. Itoh; M. Totani; M. Fujita

Clinica Chimica Acta 376(1-2) 197-204 Feb 2007 [Refereed]

Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway

H. Chin; A. Arai; H. Wakao; R. Kamiyama; N. Miyasaka; O. Miura

Blood 91(10) 3734-3745 May 1998 [Refereed]

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Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells

H. Chin; T. Saito; A. Arai; K. Yamamoto; R. Kamiyama; N. Miyasaka; O. Miura

Biochemical and Biophysical Research Communications 239(2) 412-417 Oct 1997 [Refereed]

Erythropoietin induces tyrosine phosphorylation of the interleukin-3 receptor β subunit (β(IL3)) and recruitment of Stat5 to possible Stat5- docking sites in β(IL3)

H. Chin; H. Wakao; A. Miyajima; R. Kamiyama; N. Miyasaka; O. Miura

Blood 89(12) 4327-4336 1997 [Refereed]

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Physical and functional interactions between Stat5 and the tyrosine- phosphorylated receptors for erythropoietin and interleukin-3

H. Chin; N. Nakamura; R. Kamiyama; N. Miyasaka; J.N. Ihle; O. Miura

Blood 88(12) 4415-4425 Dec 1996 [Refereed]

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An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells

N. Nakamura; H. Chin; N. Miyasaka; O. Miura

Journal of Biological Chemistry 271(32) 19483-19488 Aug 1996 [Refereed]

Association Memberships

JAPANESE SOCIETY OF LABORATORY MEDICINE(190) , THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY(91) , Japanese Association of Medical Technologists(101) , The Japanese Association for Infectious Diseases(371)

Research Grants & Projects

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Research of neutrophil functions modulated by purines.