2007年11月23日
Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins
Biochemical and Biophysical Research Communications
- 巻
- 363
- 号
- 3
- 開始ページ
- 835
- 終了ページ
- 839
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2007.09.062
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca2+-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel crosstalk in Purkinje cells (PCs). To precisely understand aberrations in JP-DKO mice, we further analyzed the mutant PCs. During the induction of cerebellar plasticity via electrical stimuli, JP-DKO PCs showed insufficient depolarizing responses. Immunochemistry detected mild impairment in synaptic maturation and hyperphosphorylation of protein kinase Cγ in JP-DKO PCs. Moreover, gene expression was slightly altered in the JP-DKO cerebellum. Therefore, the mutant PCs bear marginal but widespread abnormalities, all of which likely cause cerebellar motor defects in JP-DKO mice. © 2007 Elsevier Inc. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.bbrc.2007.09.062
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902244870124331
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17904530
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000250359400064&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34848881022&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=34848881022&origin=inward
- ID情報
-
- DOI : 10.1016/j.bbrc.2007.09.062
- ISSN : 0006-291X
- eISSN : 1090-2104
- J-Global ID : 200902244870124331
- PubMed ID : 17904530
- SCOPUS ID : 34848881022
- Web of Science ID : WOS:000250359400064