藤博幸 (Hiroyuki Toh) - マイポータル

基本情報

所属: 関西学院大学理工学部教授

学位: 博士（理学）(九州大学)

J-GLOBAL ID: 200901083991714708
researchmap会員ID: 5000059150

外部リンク: https://sci-tech.ksc.kwansei.ac.jp/~tohhiro/

研究キーワード

研究分野

ライフサイエンス / 分子生物学 /

経歴

2015年4月 - 現在

関西学院大学, 理工学部, 教授
2014年4月 - 2015年3月

産業技術総合研究所, ゲノム情報研究センター, 副研究センター長
2010年4月 - 2014年3月

産業技術総合研究所, 生命情報工学研究センター, 副研究センター長
2005年4月 - 2010年3月

九州大学, 生体防御医学研究所, 教授
2003年4月 - 2005年3月

京都大学, 化学研究所バイオインフォマティクスセンター, 特任教授
2002年10月 - 2005年3月

京都大学, 化学研究所バイオインフォマティクスセンター, 科学技術振興会研究員（常勤形態）
2002年4月 - 2002年9月

技術研究組合生物分子工学研究所, 生命情報研究部, 部長
1999年4月 - 2002年3月

（株）生物分子工学研究所, 情報解析部門, 部門長
1996年4月 - 1999年3月

（株）生物分子工学研究所, 情報解析部門, 主任研究員
1993年4月 - 1996年3月

九州工業大学, 生物化学システム工学科, 助教授
1989年1月 - 1993年3月

(株）蛋白工学研究所, 第五研究部, 研究員

論文

109

Distorted antibody repertoire developed in the absence of pre-B cell receptor formation

Lin Sun, Naoko Kono, Takeyuki Shimizu, Hiroyuki Toh, Hanbing Xue, Osamu Numata, Manabu Ato, Shigeyuki Itamura, Kazuo Ohnishi

Biochemical and Biophysical Research Communications 495(1) 1411-1417 2018年1月1日査読有り
Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis

Naoko Kono, Lin Sun, Hiroyuki Toh, Takeyuki Shimizu, Hanbing Xue, Osamu Numata, Manabu Ato, Kazuo Ohnishi, Shigeyuki Itamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 487(2) 300-306 2017年5月査読有り
Profile comparison revealed deviation from structural constraint at the positively selected sites

Hiroyuki Oda, Motonori Ota, Hiroyuki Toh

BIOSYSTEMS 147 67-77 2016年9月査読有り
GGIP: Structure and sequence-based GPCR-GPCR interaction pair predictor

Wataru Nemoto, Yoshihiro Yamanishi, Vachiranee Limviphuvadh, Akira Saito, Hiroyuki Toh

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 84(9) 1224-1233 2016年9月査読有り
Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts

Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Junko Okuno, Emi Shimizu, Kenta Kurayoshi, Kazuyuki Kugawa, Hiroyuki Toh, Kiyoshi Ohtani

GENES TO CELLS 20(9) 739-757 2015年9月査読有り
Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3)

Montasir Elahi, Monirul M. Islam, Keiichi Noguchi, Masafumi Yohda, Hiroyuki Toh, Yutaka Kuroda

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844(3) 585-592 2014年3月査読有り
Network inference of AP pattern formation system in D.melanogaster by structural equation modeling

S. Aburatani, H. Toh

2ND INTERNATIONAL CONFERENCE ON MATHEMATICAL MODELING IN PHYSICAL SCIENCES 2013 (IC-MSQUARE 2013) 490 1-4 2014年査読有り
Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

Takehiko Yokobori, Hisae Iinuma, Teppei Shimamura, Seiya Imoto, Keishi Sugimachi, Hideshi Ishii, Masaaki Iwatsuki, Daisuke Ota, Masahisa Ohkuma, Takeshi Iwaya …

CANCER RESEARCH 73(7) 2059-2069 2013年4月査読有り
Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24

Shinya Ishimaru, Koshi Mimori, Ken Yamamoto, Hiroshi Inoue, Seiya Imoto, Shuichi Kawano, Rui Yamaguchi, Tetsuya Sato, Hiroyuki Toh, Hisae Iinuma …

ANNALS OF SURGICAL ONCOLOGY 19(9) 2853-2858 2012年9月査読有り
Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

Takehiko Yokobori, Koshi Mimori, Masaaki Iwatsuki, Hideshi Ishii, Fumiaki Tanaka, Tetsuya Sato, Hiroyuki Toh, Tomoya Sudo, Takeshi Iwaya, Yoichi Tanaka …

INTERNATIONAL JOURNAL OF ONCOLOGY 41(1) 253-259 2012年7月査読有り
Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics

Wataru Nemoto, Hiroyuki Toh

BMC STRUCTURAL BIOLOGY 12 11 2012年5月査読有り
The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer.

Takatsuno Y, Mimori K, Yamamoto K, Sato T, Niida A, Inoue H, Imoto S, Kawano S, Yamaguchi R, Toh H …

Ann Surg Oncol 20 1395-1402 2012年査読有り
Evolutionary analysis of functional divergence among chemokine receptors, decoy receptors, and viral receptors

Hiromi Daiyasu, Wataru Nemoto, Hiroyuki Toh

FRONTIERS IN MICROBIOLOGY 3 264 2012年査読有り
Computational analysis of ligand recognition mechanisms by prostaglandin E-2 (subtype 2) and D-2 receptors

Hiromi Daiyasu, Takatsugu Hirokawa, Narutoshi Kamiya, Hiroyuki Toh

THEORETICAL CHEMISTRY ACCOUNTS 130(4-6) 1131-1143 2011年12月査読有り
VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion

Go Totsukawa, Yayoi Kaneko, Keiji Uchiyama, Hiroyuki Toh, Kaori Tamura, Hisao Kondo

EMBO JOURNAL 30(17) 3581-3593 2011年8月査読有り
Notch-Hes1 pathway is required for the development of IL-17-producing gamma delta T cells

Kensuke Shibata, Hisakata Yamada, Tetsuya Sato, Takashi Dejima, Masataka Nakamura, Tomokatsu Ikawa, Hiromitsu Hara, Sho Yamasaki, Ryoichiro Kageyama, Yoichiro Iwakura …

BLOOD 118(3) 586-593 2011年7月査読有り
GRIPDB - G protein coupled Receptor Interaction Partners DataBase

Wataru Nemoto, Kazuhiko Fukui, Hiroyuki Toh

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 31(3) 199-205 2011年6月査読有り
DROP: an SVM domain linker predictor trained with optimal features selected by random forest

Teppei Ebina, Hiroyuki Toh, Yutaka Kuroda

BIOINFORMATICS 27(4) 487-494 2011年2月査読有り
Protective role of the leukotriene B-4 receptor BLT2 in murine inflammatory colitis

Yoshiko Iizuka, Toshiaki Okuno, Kazuko Saeki, Hiroshi Uozaki, Shinji Okada, Takumi Misaka, Tetsuya Sato, Hiroyuki Toh, Masashi Fukayama, Naoki Takeda …

FASEB JOURNAL 24(12) 4678-4690 2010年12月査読有り
Relative von Neumann entropy for evaluating amino acid conservation

Fredrik Johansson, Hiroyuki Toh

Journal of Bioinformatics and Computational Biology 8(5) 809-823 2010年10月査読有り

もっとみる

MISC

Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization

T Suzuki, K Yamasaki, S Fujita, K Oda, M Iseki, K Yoshida, M Watanabe, H Daiyasu, H Toh, E Asamizu …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 301(3) 711-717 2003年2月
Identification of a New Cryptochrome Class: Structure, Function, and Evolution.

Molecular Cell 11, 59-67 2003年
Deduction of a regulatory network from gene expression data by the application of graphical Gaussian modeling.

Signal Processing 83, 777-788 2003年
Two novel genes expressed in Xenopus germ line: Characteristic features of putative protein structures, their gene expression profiles and their possible roles in gametogenesis and embryogenesis

Y Ikema, M Hiyoshi, H Daiyasu, H Toh, M Mori, K Takamune

MOLECULAR REPRODUCTION AND DEVELOPMENT 62(4) 421-430 2002年8月
Inference of a Genetic Network by a Combined Approach of Cluster Analysis and Graphical Gaussian Modeling

Bioinformatics 18, 287-297 2002年
System for automatically inferring a genetic network from expression profiles

J. Biol. Phys 28, 449-464 2002年
An analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase

Protein Engineering 15, 987-995 2002年
Biochemical Analysis of Replication Factor C from the Hyperthermophilic Archaeon Pyrococcus furiosus.

J. Bacteriol 183, 2614-2623 2001年
Expansion of the zinc-metallo hydrolase family of the b-lactamase fold.

FEBS Lett. 503, 1-6 2001年
A local structural alignment method that accommodates with circular permutation.

CBI Journal 1, 103-114 2001年
Three novel repetitive units of Reelin

Molecular Brain Research 97, 190-193 2001年
Statistical estimation of cluster boundaries in gene expression profile data

Bioinformatics 17, 1143-1151 2001年
Mutational analysis of the Pyrococcus furiosus Holliday junction resolvase hjc revealed functionally important residues for dimer formation, junction DNA binding, and cleavage activities

Kayoko Komori, Shinzi Sakae, Hiromi Daiyasu, Hiroyuki Toh, Kosuke Morikawa, Hideo Shinagawa, Yoshizumi Ishino

Journal of Biological Chemistry 275(51) 40385-40391 2000年12月22日
A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene.

Genetics 154, 1451-1461 2000年
Mutational analysis of the functional motifs of RuvB, an AAA+ class helicase and motor protein for Holliday junction branch migration.

Mol. Microbiol 36, 528-538 2000年
Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803

Nucleic Acids Res 28, 2353-2362 2000年
Homology modeling of leptin/leptin receptor complex

Biochem. Biophys. Res. Commun 275, 154-158 2000年
Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish.

Genes Cells 5, 725-738 2000年
Domain analysis of an archaeal RadA protein for the strand exchange activity.

J. Biol. Chem 275, 33791-33797 2000年
Hjc resolvase is a distantly related member of the type II restriction endonuclease family

Nucleic Acids Res 28, 4540-4543 2000年

もっとみる

書籍等出版物

Phylogenetic Footprinting

Toh, H

Encyclopedia of Bioinformatics and Computational Biology 1st Edition ABC of Bioinformatics (Eds. Ranganathan, S., Nakai, K., Shorbach, C.), Elsevier 2018年
Estimation of Physical Transcriptional Control in Yeast Cell Cycle by Structure Equation Modeling.

Aburatani, S, Toh, H

Protein Purification and Analysis I, iConcept Press 2013年
Evoltionary analysis of lipocalin-type prostaglandin D2 synthase.

Ichihara, H, Kuma, K, Urade, Y, Toh, H

prostaglandin D2 synthase - A Multitude of Biological Functions (Ed. Ragolia, L.),Research Signpost, Kerala 2007年
Inference of Protein-Protein Interaction by Using Co-evolutionary Information

Sato, T, Yamanishi, Y, Horimoto, K, Kanehisa, M, Toh, H

Algebraic Biology - 2nd International Conference, Algebraic Biology 2007 Proceedings - (Eds. Anai, H., Horimoto, K., Kursita T.), Springer, Berlin 2007年
Molecular evolution of proteins involved in the arachidonic acid cascade

Comprehensive Natural Products Chemistry. (Eds. Barton et al.) Volume I Polyketides and secondary metabolites including fatty acids and their derivatives. Elsevier, Amsterdam 1999年
Cyclooxygenase (prostaglandin H synthase):structure and evolutionary aspects

Eicosanoids and Related Compounds in Plants and Animals. (Eds. Rowley et al.) Portland Press, London 1998年
Homology search and prediction of biological function of protein from amino acid sequences.

Methods in Protein Sequence Analysis (Eds. Imahori and Sakiyama) Plenum Press, New York 1993年
Sequence homology among reverse transcriptase-containing viruses and transposable genetic element: functional and evolutionary implications.

Miyata, T, Toh, H, Hayashida, H, Kikuno, R, Inokuchi, Y, Saigo, K

Populaton Genetics and Molecular Evolution, (Eds. Ohta and Aoki) Japan Sci. Soc. Press, Tokyo/Springer-Verlag, Berlin, 1985年
Evolution of Interferon Genes.

Miyata, T, Hayashida, H, Kikuno, R, Toh, H, Kawade, Y

Interferon 6 (Eds. Gresser et al.), Academic Press, London 1985年

藤博幸

基本情報

研究キーワード

研究分野

経歴

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

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