池口文彦 (Yoshihiko Ikeguchi) - マイポータル

基本情報

学位: 博士(東京理科大学大学院薬学系研究科)
修士(東京大学大学院薬学系研究科)
学士(東京大学薬学部)

J-GLOBAL ID: 200901023326277310
researchmap会員ID: 5000059698

研究キーワード

研究分野

経歴

2000年 - 2003年

米国ペンシルバニア州立大学医学部博士研究員
2000年 - 2003年

Postdoctoralfellow, Pehnsylvania State
University College of Medicine

学歴

- 2000年

東京理科大学大学院, 薬学研究科, 薬学
- 1992年

東京大学, 薬学部, 製薬化学科

論文

A rational free energy-based approach to understanding and targeting disease-causing missense mutations

Zhe Zhang, Shawn Witham, Marharita Petukh, Gautier Moroy, Maria Miteva, Yoshihiko Ikeguchi, Emil Alexov

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION 20(4) 643-651 2013年7月査読有り
Determination of Cellular Aminopropyltransferase Activity Using Precolumn Fluorescent Etheno-Derivatization with High-Performance Liquid Chromatography

Kenichi Yamazaki, Yoshihiko Ikeguchi, Takuya Niwa, Kaoru Hayashi, Takahiro Iwaki, Ikumi Ishii, Masaru Niitsu, Anthony E. Pegg, Akira Shirahata

ANALYTICAL SCIENCES 28(6) 621-624 2012年6月査読有り
Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

Ikumi Ishii, Yoshihiko Ikeguchi, Hiroshi Mano, Masahiro Wada, Anthony E. Pegg, Akira Shirahata

AMINO ACIDS 42(2-3) 619-626 2012年2月査読有り
Brain infarction correlates more closely with acrolein than with reactive oxygen species.

Ryotaro Saiki, Hyerim Park, Itsuko Ishii, Madoka Yoshida, Kazuhiro Nishimura, Toshihiko Toida, Hideki Tatsukawa, Soichi Kojima, Yoshihiko Ikeguchi, Anthony E Pegg, Keiko Kashiwagi, Kazuei Igarashi

Biochemical and biophysical research communications 404(4) 1044-9 2011年1月28日査読有り
Crystal structure of human spermine synthase - Implications of substrate binding and catalytic mechanism

Hong Wu, Jinrong Min, Hong Zeng, Diane E. McCloskey, Yoshihiko Ikeguchi, Peter Loppnau, Anthony J. Michael, Anthony E. Pegg, Alexander N. Plotnikov

JOURNAL OF BIOLOGICAL CHEMISTRY 283(23) 16135-16146 2008年6月査読有り
Amine modification of digested peptide at C-terminal end during protein digestion by protease

Toshiyuki Ito, Yoshiaki Sugita, Koichi Takao, Yoshihiko Ikeguchi, Akira Shirahata

BIOLOGICAL & PHARMACEUTICAL BULLETIN 30(10) 1838-1843 2007年10月査読有り
Formation of polyamine-modified peptides during protein digestion

Toshiyuki Ito, Yoshiaki Sugita, Yoshihiko Ikeguchi, Akira Shirahata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356(1) 159-162 2007年4月査読有り
Aminopropyltransferases: Function, structure and genetics

Y Ikeguchi, MC Bewley, AE Pegg

JOURNAL OF BIOCHEMISTRY 139(1) 1-9 2006年1月査読有り
Spermine synthesis is required for normal viability, growth, and fertility in the mouse

XJ Wang, Y Ikeguchi, DE McCloskey, P Nelson, AE Pegg

JOURNAL OF BIOLOGICAL CHEMISTRY 279(49) 51370-51375 2004年12月査読有り
Characterization of transgenic mice with widespread overexpression of spermine synthase

Y Ikeguchi, XJ Wang, DE McCloskey, CS Coleman, P Nelson, GR Hu, LM Shantz, AE Pegg

BIOCHEMICAL JOURNAL 381(3) 701-707 2004年8月査読有り
X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome

AL Cason, Y Ikeguchi, C Skinner, TC Wood, KR Holden, HA Lubs, F Martinez, RJ Simensen, RE Stevenson, AE Pegg, CE Schwartz

EUROPEAN JOURNAL OF HUMAN GENETICS 11(12) 937-944 2003年12月査読有り
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents

Y Ikeguchi, CA Mackintosh, DE McCloskey, AE Pegg

BIOCHEMICAL JOURNAL 373(3) 885-892 2003年8月査読有り
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

S Korolev, Y Ikeguchi, T Skarina, S Beasley, C Arrowsmith, A Edwards, A Joachimiak, AE Pegg, A Savchenko

NATURE STRUCTURAL BIOLOGY 9(1) 27-31 2002年1月査読有り

MISC

Crystal structure of human spermine synthase - Implications of substrate binding and catalytic mechanism

Hong Wu, Jinrong Min, Hong Zeng, Diane E. McCloskey, Yoshihiko Ikeguchi, Peter Loppnau, Anthony J. Michael, Anthony E. Pegg, Alexander N. Plotnikov

JOURNAL OF BIOLOGICAL CHEMISTRY 283(23) 16135-16146 2008年6月
Structure and mechanism of spermidine synthases

Hong Wu, Jinrong Min, Yoshihiko Ikeguchi, Hong Zeng, Aiping Dong, Peter Loppnau, Anthony E. Pegg, Alexander N. Plotnikov

BIOCHEMISTRY 46(28) 8331-8339 2007年7月
Aminopropyltransferases: Function, structure and genetics

Y Ikeguchi, MC Bewley, AE Pegg

JOURNAL OF BIOCHEMISTRY 139(1) 1-9 2006年1月
Spermine synthesis is required for normal viability, growth, and fertility in the mouse

XJ Wang, Y Ikeguchi, DE McCloskey, P Nelson, AE Pegg

JOURNAL OF BIOLOGICAL CHEMISTRY 279(49) 51370-51375 2004年12月
Spermine synthesis is required for normal viability, growth, and fertility in the mouse

XJ Wang, Y Ikeguchi, DE McCloskey, P Nelson, AE Pegg

JOURNAL OF BIOLOGICAL CHEMISTRY 279(49) 51370-51375 2004年12月
Characterization of transgenic mice with widespread overexpression of spermine synthase

Y Ikeguchi, XJ Wang, DE McCloskey, CS Coleman, P Nelson, GR Hu, LM Shantz, AE Pegg

BIOCHEMICAL JOURNAL 381 701-707 2004年8月
Characterization of transgenic mice with widespread overexpression of spermine synthase

Y Ikeguchi, XJ Wang, DE McCloskey, CS Coleman, P Nelson, GR Hu, LM Shantz, AE Pegg

BIOCHEMICAL JOURNAL 381(3) 701-707 2004年8月
X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome

AL Cason, Y Ikeguchi, C Skinner, TC Wood, KR Holden, HA Lubs, F Martinez, RJ Simensen, RE Stevenson, AE Pegg, CE Schwartz

EUROPEAN JOURNAL OF HUMAN GENETICS 11(12) 937-944 2003年12月
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents

Y Ikeguchi, CA Mackintosh, DE McCloskey, AE Pegg

BIOCHEMICAL JOURNAL 373 885-892 2003年8月
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents

Y Ikeguchi, CA Mackintosh, DE McCloskey, AE Pegg

BIOCHEMICAL JOURNAL 373(3) 885-892 2003年8月
X-linked spermine synthase gene(SMS) defect:the first polyamine deficiency syndrome

European Journal of Human Genetics 11, 937-944 2003年
The crystal structure of spermidine synthase with a multi substrate adduct inhibiter

Nature Structural Biology 9, 27-31 2002年
The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

S Korolev, Y Ikeguchi, T Skarina, S Beasley, C Arrowsmith, A Edwards, A Joachimiak, AE Pegg, A Savchenko

NATURE STRUCTURAL BIOLOGY 9(1) 27-31 2002年1月

所属学協会

共同研究・競争的資金等の研究課題

ポリアミンの生化学的・生理的役割の解明

補助金 2000年
Research for the biochemical and physiological role of polyamine

Grants and Funding 2000年
Research for the biochemical and physiological role of polyamine

0023 (Japanese Only) 2000年