2005年3月
Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy
FEBS LETTERS
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- 巻
- 579
- 号
- 7
- 開始ページ
- 1602
- 終了ページ
- 1606
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.febslet.2005.01.074
- 出版者・発行元
- ELSEVIER SCIENCE BV
To explore how the sulfonylurea receptor (SUR1) is involved in docking and fusion of insulin granules, dynamic motion of single insulin secretory granules near the plasma membrane was examined in SUR1 knock-out (Sur1KO) beta-cells by total internal reflection fluorescence microscopy. Sur1KO beta-cells exhibited a marked reduction in the number of fusion events from previously docked granules. However, the number of docked granules declined during stimulation as a consequence of the release of docked granules into the cytoplasm vs. fusion with the plasma membrane. Thus, the impaired docking and fusion results in decreased insulin exocytosis from Sur1KO beta-cells. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.febslet.2005.01.074
- CiNii Articles
- http://ci.nii.ac.jp/naid/80017232831
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15757648
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000227657500007&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.febslet.2005.01.074
- ISSN : 0014-5793
- CiNii Articles ID : 80017232831
- PubMed ID : 15757648
- Web of Science ID : WOS:000227657500007