書籍等出版物

2016年3月

Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis

  • R. Ueoka
  • ,
  • Y. Matsumoto
  • ,
  • H. Ichihara
  • ,
  • Y. Komizu

担当区分
共著
出版者・発行元
Springer
総ページ数
270
担当ページ
221-244
記述言語
英語
著書種別
学術書

The uniform and stable structure of HL composed of DMPC and C12(EO)n with a diameter of 80 nm was revealed. The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. Induction of apoptosis by HL was obtained and the pathway of apoptosis induced by HL was clarified. A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL without any side effects in vivo. In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.