書籍等出版物

2011年6月

Membrane Targeted Chemotherapy with Hybr id Liposomes for Tumor Cells Leading to Apoptosis

  • Ueoka R
  • ,
  • Matsumoto Y
  • ,
  • Goto K
  • ,
  • Ichihara H
  • ,
  • Komizu Y

担当区分
共著
出版者・発行元
Bentham Science Publishers
総ページ数
担当ページ
1709-1719
記述言語
英語
著書種別
学術書

We have employed HL for chemotherapy and interesting results are as follows; (A) The uniform and stable structure of HL composed of L-alfa-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenedodecyl ether (C12(EO)n) with a diameter of 80 nm was revealed. (B) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (C) Induction of apoptosis by HL was obtained and the pathway of apoptosis induced by HL was clarified. (D) A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. (E) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL without any side effects in vivo. (F) In clinical applications, prolonged survival and remarkable reduction of neoplasm were attained in patients with lymphoma after the treatment with HL without any side effects after the approval of the bioethics committee.