書籍等出版物

2002年8月

Chemotherapy with Hybrid Liposomes Composed of Dimyristoylphosphatidylcholine and Polyoxyethylenealkyl Ether without Drugs

  • Ueoka R
  • ,
  • Matsumoto Y
  • ,
  • Ichihara H
  • ,
  • Kiyokawa T

担当区分
共著
出版者・発行元
American Chemical Society
総ページ数
担当ページ
177-189
記述言語
英語
著書種別
学術書
DOI
ISBN
9780841237964

Highly inhibitory effects of hybrid liposomes were obtained on the growth of tumor cells in vitro. Induction of apoptosis by hybrid liposomes through activation of caspase-3 was verified using flow cytometry and microphysiometer. Significantly prolonged survival was obtained in mice inoculated tumor cells after the treatment with hybrid liposomes without any side effect. In clinical applications, prolonged survival was attained in patients with lymphoma after the intravenous injection of hybrid liposomes without drugs and the remarkable reduction of solid tumor was obtained after the local administration of hybrid liposomes.