MISC

1998年11月

The mechanism of high-density lipoprotein cholesterol elevation in patients treated with simvastatin

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • M Tsuji
  • ,
  • H Ide
  • ,
  • N Yabunaka
  • ,
  • Y Otsuka
  • ,
  • K Tsuchihashi
  • ,
  • S Gasa

59
11
開始ページ
773
終了ページ
784
記述言語
英語
掲載種別
DOI
10.1016/S0011-393X(98)85103-5
出版者・発行元
EXCERPTA MEDICA INC

Fourteen patients with untreated hypercholesterolemia were given simvastatin 5 mg/d for 12 weeks. Cholesteryl ester transfer protein (CETP) activity and lecithin-cholesterol acyltransferase (LCAT) activity were determined every 4 weeks during treatment. Total cholesterol (TC) decreased from 279.1 +/- 55.1 mg/dL before treatment to 224.6 +/- 30.7 mg/dL after 12 weeks, and high-density Lipoprotein cholesterol (HDL-C) rose from 56.2 +/- 13 mg/dL to 61.2 +/- 15.2 mg/dL, These changes were statistically significant. CETP activity decreased significantly from 26.8 +/- 6.4% before treatment to 23.6 +/- 6.3% after 12 weeks, and LCAT activity at 37 degrees C increased significantly from 43.3 +/- 33.5 nmol/mL per hour to 68.4 +/- 32.6 nmol/mL per hour. The changes in TC correlated with those in CETP activity at each time point (r = .674), but not with those in LCAT activity. The HDL-C level was negatively correlated with CETP activity at each time point (r = .655) but not with LCAT activity. These findings show that CETP activity may play a more important role than LCAT activity in simvastatin-induced HDL-C elevation and suggest that simvastatin increases HDL-C by reducing CETP activity secondary to low-density lipoprotein cholesterol reduction.


リンク情報
DOI
https://doi.org/10.1016/S0011-393X(98)85103-5
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000077054900004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0011-393X(98)85103-5
  • ISSN : 0011-393X
  • Web of Science ID : WOS:000077054900004

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