長瀬尚志 (HISASHI NAGASE) - マイポータル

基本情報

所属: 信州大学医学部　医学科　寄生虫感染症学助教

J-GLOBAL ID: 200901042253825300
researchmap会員ID: 5000069602

研究分野

ライフサイエンス / 寄生虫学 /

論文

Endogenous IFN-gamma facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell-depleted mice

Yi Wang, Hisashi Nagase, Yoh-ichi Tagawa, Shinsuke Taki, Masaya Takamoto, ( Y. Wang and H. Nagase equally contributed to this work.)

FEBS Letters 598(13) 1633-1643 2024年6月査読有り筆頭著者
State-of-the-Art Cancer Immunotherapies.

Hisashi Nagase, Takuma Kato, Takayuki Yoshimoto

International journal of molecular sciences 25(5) 2024年2月22日査読有り筆頭著者
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice.

Hisashi Nagase, Masaya Takamoto, Nancy Noben-Trauth

Cellular immunology 393-394 104779-104779 2023年査読有り筆頭著者責任著者
Potential Therapeutic Targets and gamma-Secretase-Regulated APP Signaling in Alzheimer’s Disease

Hisashi Nagase, Kohzo Nakayama

Anals of Neurodegenerative Disorders 2016年
The Intracellular Domain of Amyloid Precursor Protein is a Potential Therapeutic Target in Alzheimer's Disease.

Hisashi Nagase, Kohzo Nakayama

Current drug discovery technologies 11(4) 243-58 2014年筆頭著者
γ-Secretase-regulated signaling typified by Notch signaling in the immune system.

Hisashi Nagase, Kohzo Nakayama

Current stem cell research & therapy 8(5) 341-56 2013年9月筆頭著者
γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh, Takeshi Ohkawara

Cellular and molecular neurobiology 31(6) 887-900 2011年8月
γ-Secretase-regulated signaling pathways, such as notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses.

Hisashi Nagase, Chang-Sung Koh, Kohzo Nakayama

Current stem cell research & therapy 6(2) 131-41 2011年6月筆頭著者
The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.

Takeshi Ohkawara, Hisashi Nagase, Chang-Sung Koh, Kohzo Nakayama

Gene 475(1) 1-9 2011年4月1日査読有り
Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.

Kohzo Nakayama, Hisashi Nagase, Masahiro Hiratochi, Chang-Sung Koh, Takeshi Ohkawara

Current stem cell research & therapy 3(4) 288-302 2008年12月
The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.

Kohzo Nakayama, Takeshi Ohkawara, Masahiro Hiratochi, Chang-Sung Koh, Hisashi Nagase

Neuroscience letters 444(2) 127-31 2008年10月24日査読有り最終著者
Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.

Hisashi Nagase, Kathryn M Jones, Charles F Anderson, Nancy Noben-Trauth

Journal of immunology (Baltimore, Md. : 1950) 179(4) 2435-44 2007年8月15日査読有り筆頭著者
The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.

Masahiro Hiratochi, Hisashi Nagase, Yu Kuramochi, Chang-Sung Koh, Takeshi Ohkawara, Kohzo Nakayama

Nucleic acids research 35(3) 912-22 2007年査読有り
The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.

Nancy Noben-Trauth, Rosalia Lira, Hisashi Nagase, William E Paul, David L Sacks

Journal of immunology (Baltimore, Md. : 1950) 170(10) 5152-8 2003年5月15日査読有り
Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells.

Akio Matsuzawa, Motomu Shimizu, Yasutaka Takeda, Hisashi Nagase, Kazutoshi Sayama, Mikio Kimura

Immunology 106(4) 470-5 2002年8月査読有り
Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor.

Akihiro Tsukadaira, Yoshio Okubo, Sekiya Koyama, Etsuro Sato, Hisashi Nagase, Kazunaga Agematsu, Koh Nakazawa

Experimental lung research 28(2) 123-39 2002年3月査読有り
The different process of class switching and somatic hypermutation; a novel analysis by CD27(-) naive B cells.

Haruo Nagumo, Kazunaga Agematsu, Norimoto Kobayashi, Koji Shinozaki, Sho Hokibara, Hisashi Nagase, Masaya Takamoto, Kozo Yasui, Kazuo Sugane, Atsushi Komiyama

Blood 99(2) 567-75 2002年1月15日査読有り
Characterization of mouse mammary tumour virus-induced migration of lymphoid cells into lymph nodes.

A Matsuzawa, T Yasuda, S Sakamoto, H Nagase, H Nakano, T Yoshimoto

Scandinavian journal of immunology 53(6) 553-62 2001年6月
Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis

Hisashi Nagase, Kazunaga Agematsu, Kiyoshi Kitano, Masaya Takamoto, Yoshio Okubo, Atsushi Komiyama, Kazuo Sugane

Clinical Immunology 100(2) 250-259 2001年
A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice.

Y Zhang, T Yasuda, C R Wang, T Yoshimoto, H Nagase, M Takamoto, A Tsubura, M Kimura, A Matsuzawa

Clinical and experimental immunology 122(1) 124-32 2000年10月

もっとみる

書籍等出版物

Present and Future Therapies for Alzheimer's Disease

Hisashi Nagase, Kohzo Nakayama (担当:共著, 範囲:Immunoregulatory Aspects of Immunotherapy, Chapter 8)

InTechOpen 2018年
Amyloid Precursor Protein: Its signaling aspect and Alzheimer's disease

Kohzo Nakayama, Hisashi Nagase, Chang-Sung Koh, Takeshi Ohkawara (担当:共著, 範囲:Amyloids: Composition, Functions and Pathology, Chapter 2)

Nova Science Publishers, Inc. 2012年

共同研究・競争的資金等の研究課題

ＩＬ－１の活性制御機構に注目した新たな炎症性疾患動物モデルの作出

日本学術振興会科学研究費助成事業基盤研究(C) 2012年4月 - 2015年3月

角田茂, 松本清司, 森政之, 長瀬尚志
γ-セクレターゼ制御Deltaシグナルの末梢CD4T細胞分化における役割

日本学術振興会科学研究費助成事業若手研究(B) 2010年 - 2012年

長瀬尚志
寄生蠕虫プロテアーゼのTh2分化における役割に関する研究

日本学術振興会科学研究費助成事業奨励研究(A) 1999年 - 2000年

長瀬尚志
寄生虫感染時のTH2分化のメカニズムの解析

長瀬尚志

基本情報

研究分野

論文

書籍等出版物

共同研究・競争的資金等の研究課題

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