2012年12月
Enhanced Glutamate Uptake into Synaptic Vesicles Fueled by Vesicle-generated ATP from Phosphoenolpyruvate and ADP
NEUROCHEMICAL RESEARCH
- ,
- 巻
- 37
- 号
- 12
- 開始ページ
- 2731
- 終了ページ
- 2737
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11064-012-0864-4
- 出版者・発行元
- SPRINGER/PLENUM PUBLISHERS
Glycolytic ATP synthesis by synaptic vesicles provides an efficient mechanism for fueling vesicular loading of the neurotransmitter glutamate. This is achieved in part by vesicle-bound pyruvate kinase. However, we have found that vesicular glutamate uptake, in the presence of the pyruvate kinase substrates ADP and phosphoenolpyruvate (PEP), substantially exceeds that caused by exogenous ATP. We propose that this much enhanced uptake is in part due to extra ATP produced via a mechanism involving a novel enzyme, PEP-dependent ADP synthase. We discuss implications for this enzyme in energy homeostasis and pathophysiology, as well as in efficient synaptic glutamate transmission.
- リンク情報
- ID情報
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- DOI : 10.1007/s11064-012-0864-4
- ISSN : 0364-3190
- Web of Science ID : WOS:000311537300010