2010年11月
Reduced Expression of the vca0421 Gene of Vibrio cholerae O1 Results in Innate Resistance to Ciprofloxacin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- 巻
- 54
- 号
- 11
- 開始ページ
- 4917
- 終了ページ
- 4919
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/AAC.01652-09
- 出版者・発行元
- AMER SOC MICROBIOLOGY
A mini-Tn5 insertion into a ciprofloxacin (CIP)-resistant mutant of Vibrio cholerae O1 revealed that overexpression of the vca0421 gene, which encodes a hypothetical protein, in the CIP-resistant mutant carrying a mutation in the quinolone resistance-determining region (QRDR) of the gyrA gene causes sensitization to CIP. We propose a new intrinsic mechanism of resistance to fluoroquinolones due to the inherently reduced expression of the vca0421 gene in V. cholerae O1.
- リンク情報
- ID情報
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- DOI : 10.1128/AAC.01652-09
- ISSN : 0066-4804
- PubMed ID : 20805389
- Web of Science ID : WOS:000284155000057