2010年9月
Electrochemical concentration of no-carrier-added [F-18]fluoride from [O-18]water in a disposable microfluidic cell for radiosynthesis of F-18-labeled radiopharmaceuticals
APPLIED RADIATION AND ISOTOPES
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- 巻
- 68
- 号
- 9
- 開始ページ
- 1703
- 終了ページ
- 1708
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.apradiso.2010.02.005
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [F-18]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [F-18]fluoride was introduced into a disposable microfluidic cell (16 mu L) under an electric potential (10V), followed by anhydrous MeCN. The trapped [F-18]fluoride was released in MeCN containing Kryptofix (R) 222-KHCO3 (ca. 60 mu L) under heat and a reversed potential (-2.5V). An automated module provided the [F-18]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6 min. (C) 2010 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.apradiso.2010.02.005
- ISSN : 0969-8043
- Web of Science ID : WOS:000279415800018