2016年1月
Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards
PHYSICS IN MEDICINE AND BIOLOGY
- 巻
- 61
- 号
- 2
- 開始ページ
- 696
- 終了ページ
- 711
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1088/0031-9155/61/2/696
- 出版者・発行元
- IOP PUBLISHING LTD
The aim of this study was to evaluate the performance of ClairvivoPET using NEMA NU4 standards.
The ClairvivoPET incorporates a LYSO dual depth-of-interaction detector system with 151 mm axial field of view (FOV). Spatial resolution, sensitivity, counting rate capabilities, and image quality were evaluated using NEMA NU4-2008 standards. Normal mouse imaging was also performed for 10min after intravenous injection of F-18(-)-NaF. Data were compared with 19 other preclinical PET scanners.
Spatial resolution measured using full width at half maximum on FBP-ramp reconstructed images was 2.16 mm at radial offset 5 mm of the axial centre FOV. The maximum absolute sensitivity for a point source at the FOV centre was 8.72%. Peak noise equivalent counting rate (NECR) was 415kcps at 14.6MBq ml(-1). The uniformity with the image-quality phantom was 4.62%. Spillover ratios in the images of air and water filled chambers were 0.19 and 0.06, respectively. Our results were comparable with the 19 other preclinical PET scanners based on NEMA NU4 standards, with excellent sensitivity because of the large FOV. The ClairvivoPET with iterative reconstruction algorithm also provided sufficient visualization of the mouse spine.
The high sensitivity and resolution of the ClairvivoPET scanner provided high quality images for preclinical studies.
The ClairvivoPET incorporates a LYSO dual depth-of-interaction detector system with 151 mm axial field of view (FOV). Spatial resolution, sensitivity, counting rate capabilities, and image quality were evaluated using NEMA NU4-2008 standards. Normal mouse imaging was also performed for 10min after intravenous injection of F-18(-)-NaF. Data were compared with 19 other preclinical PET scanners.
Spatial resolution measured using full width at half maximum on FBP-ramp reconstructed images was 2.16 mm at radial offset 5 mm of the axial centre FOV. The maximum absolute sensitivity for a point source at the FOV centre was 8.72%. Peak noise equivalent counting rate (NECR) was 415kcps at 14.6MBq ml(-1). The uniformity with the image-quality phantom was 4.62%. Spillover ratios in the images of air and water filled chambers were 0.19 and 0.06, respectively. Our results were comparable with the 19 other preclinical PET scanners based on NEMA NU4 standards, with excellent sensitivity because of the large FOV. The ClairvivoPET with iterative reconstruction algorithm also provided sufficient visualization of the mouse spine.
The high sensitivity and resolution of the ClairvivoPET scanner provided high quality images for preclinical studies.
- リンク情報
- ID情報
-
- DOI : 10.1088/0031-9155/61/2/696
- ISSN : 0031-9155
- eISSN : 1361-6560
- Web of Science ID : WOS:000369516600019