1999年10月
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme
NATURE
- ,
- ,
- ,
- ,
- ,
- 巻
- 401
- 号
- 6754
- 開始ページ
- 713
- 終了ページ
- 718
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/44394
- 出版者・発行元
- MACMILLAN MAGAZINES LTD
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes' and is used to treat neutropenia(2), GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M (ref. 3), Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a noncrystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
- リンク情報
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- DOI
- https://doi.org/10.1038/44394
- CiNii Articles
- http://ci.nii.ac.jp/naid/80011367228
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10537111
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083207400060&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1038/44394
- ISSN : 0028-0836
- CiNii Articles ID : 80011367228
- PubMed ID : 10537111
- Web of Science ID : WOS:000083207400060