Takashi Saito

Profile Information

Affiliation: Research_Center_for_Allergy_and_Immunology, Yokohama Institute, RIKEN(The Institute of Physical and Chemical Research)
: 客員教授, 東京医科歯科大学大学院生命情報科学教育部
: 招聘教授, 大阪大学免疫学フロンティア研究センター
: 客員教授, 千葉大学大学院医学薬学府

Degree: Ph.D.

J-GLOBAL ID: 200901040469121933
researchmap Member ID: 5000072368

Research Interests

Research Areas

Research History

Apr, 1989

. 千葉大学
Apr, 1988

. 千葉大学医学部・附属高次機能制御研究センター・免疫機能分野助手
Mar, 1988

. 千葉大学医学部・附属環境疫学研究施設免疫研究部助手
Jun, 1985

. 国立衛生局（NIH）国立アレルギー感染症研究所（米国）研究員
May, 1982

. ケルン大学遺伝学研究所（西ドイツ）研究員
Apr, 1982

. 日本学術振興会奨励研究員
1977 - 1982

Graduate student
1979

Research Assistant
Department of Microbiology (Dr. J.
Laboratory of Immunology (Dr. Tomio Tada and Dr. Masaru Taniguchi), School of Medicine, Chiba University, Chiba, Japan

Education

- 1982

Chiba University
- 1982

Immunology, Graduate School, Division of Science and Technology, Chiba University

Committee Memberships

Papers

153

A motif in the V3 domain of the kinase PKC-theta determines its localization in the immunological synapse and functions in T cells via association with CD28

Kok-Fai Kong, Tadashi Yokosuka, Ann J. Canonigo-Balancio, Noah Isakov, Takashi Saito, Amnon Altman

NATURE IMMUNOLOGY, 12(11) 1105-U114, Nov, 2011 Peer-reviewed
99

Nanocluster Formation: More with Memory

Takashi Saito

IMMUNITY, 35(3) 318-320, Sep, 2011 Invited
CIN85 regulates the canonical NF-kB pathway and subsequent B cell responses.

Kometani K, Yamada, T, Sasaki, Y, Yokosuka, T, Saito, T, Rajewsky, K, Ishiai, M, Hikida, M, Kurosaki, T

J. Exp. Med., 208(7) 1447-1457, Jul, 2011 Peer-reviewed
49

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

Akiko Hashimoto-Tane, Tadashi Yokosuka, Kumiko Sakata-Sogawa, Machie Sakuma, Chitose Ishihara, Makio Tokunaga, Takashi Saito

IMMUNITY, 34(6) 919-931, Jun, 2011 Peer-reviewed
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid

Masahiko Yabu, Hiroaki Shime, Hiromitsu Hara, Takashi Saito, Misako Matsumoto, Tsukasa Seya, Takashi Akazawa, Norimitsu Inoue

INTERNATIONAL IMMUNOLOGY, 23(1) 29-41, Jan, 2011 Peer-reviewed
A Heat-Stable Extract From Mucuna Stimulates the Differentiation of Bone Marrow Cells Into Dendritic Cells and Induces Apoptosis in Cancer Cells

Kazuhiko Kurokawa, Takao Ishii, Wei-wei An, Yasuko Kanazawa, Mutsumi Ozawa, Takashi Ichiyanagi, Takashi Saito, Eiji Nishihara, Kazuyasu Nakaya

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 63(1) 100-108, 2011 Peer-reviewed
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Koji Atarashi, Takeshi Tanoue, Tatsuichiro Shima, Akemi Imaoka, Tomomi Kuwahara, Yoshika Momose, Genhong Cheng, Sho Yamasaki, Takashi Saito, Yusuke Ohba …

SCIENCE, 331(6015) 337-341, Jan, 2011 Peer-reviewed
Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters

Takashi Saito, Tadashi Yokosuka, Akiko Hashimoto-Tane

FEBS LETTERS, 584(24) 4865-4871, Dec, 2010 Peer-reviewed
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation

Eri Ishikawa, Yasunobu Miyake, Hiromitsu Hara, Takashi Saito, Sho Yamasaki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(46) 19979-19984, Nov, 2010 Peer-reviewed
Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

Tadashi Yokosuka, Wakana Kobayashi, Masako Takamatsu, Kumiko Sakata-Sogawa, Hu Zeng, Akiko Hashimoto-Tane, Hideo Yagita, Makio Tokunaga, Takashi Saito

IMMUNITY, 33(3) 326-339, Sep, 2010 Peer-reviewed
T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering

Akiko Hashimoto-Tane, Tadashi Yokosuka, Chitose Ishihara, Machie Sakuma, Wakana Kobayashi, Takashi Saito

MOLECULAR AND CELLULAR BIOLOGY, 30(14) 3421-3429, Jul, 2010 Peer-reviewed
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.

Shinobu Saijo, Satoshi Ikeda, Keiko Yamabe, Shigeru Kakuta, Harumichi Ishigame, Aoi Akitsu, Noriyuki Fujikado, Toshimasa Kusaka, Sachiko Kubo, Soo-hyun Chung …

Immunity, 32(5) 681-91, May 28, 2010 Peer-reviewed
Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4(+) T cells

Takayoshi Owada, Norihiko Watanabe, Mie Oki, Yoshihiro Oya, Yasushi Saito, Takashi Saito, Itsuo Iwamoto, Theresa L. Murphy, Kenneth M. Murphy, Hiroshi Nakajima

JOURNAL OF LEUKOCYTE BIOLOGY, 87(3) 425-432, Mar, 2010 Peer-reviewed
Dendritic Cell Differentiation and Tumor Cell Apoptosis Induced by Components of a Poly-phenylpropanoid Polysaccharide Complex

Wei-Wei An, Yasuko Kanazawa, Mutsumi Ozawa, Kazuyasu Nakaya, Takashi Saito, Akiko Tanaka, William Guy Bradley

ANTICANCER RESEARCH, 30(2) 613-622, Feb, 2010 Peer-reviewed
CRTAM Confers Late-Stage Activation of CD8(+) T Cells to Regulate Retention within Lymph Node

Arata Takeuchi, Yasushi Itoh, Akiko Takumi, Chitose Ishihara, Noriko Arase, Tadashi Yokosuka, Haruhiko Koseki, Sho Yamasaki, Yoshimi Takai, Jun Miyoshi …

JOURNAL OF IMMUNOLOGY, 183(7) 4220-4228, Oct, 2009 Peer-reviewed
Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal

Satoru Hara, Chiaki Nakaseko, Sho Yamasaki, Masakazu Hattori, Johannes L. Bos, Yasushi Saito, Nagahiro Minato, Takashi Saito

HEMATOLOGY, 14(3) 150-158, Jun, 2009 Peer-reviewed
Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease

Kaori Sato, Kawori Eizumi, Tomohiro Fukaya, Shigeharu Fujita, Yumiko Sato, Hideaki Takagi, Mai Yamamoto, Naohide Yamashita, Atsushi Hijikata, Hiroshi Kitamura …

BLOOD, 113(19) 4780-4789, May, 2009 Peer-reviewed
CARD9 versus CARMA1 in innate and adaptive immunity

Hiromitsu Hara, Takashi Saito

TRENDS IN IMMUNOLOGY, 30(5) 234-242, May, 2009 Invited
The Global Thymus Network: past, present and future

Yousuke Takahama, Takashi Saito, Hiroshi Kawamoto, Manami Itoi, Richard L. Boyd, Ann Chidgey, Rose Zamoyska, Georg A. Hollaender, Graham Anderson, Naomi Taylor …

TRENDS IN IMMUNOLOGY, 30(5) 191-192, May, 2009 Invited
Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

Tadashi Yokosuka, Takashi Saito

IMMUNOLOGICAL REVIEWS, 229 27-40, May, 2009 Invited

Misc.

137

Inhibitory adaptors in lymphocytes

S Yamasaki, T Saito

SEMINARS IN IMMUNOLOGY, 16(6) 421-427, Dec, 2004
The quantity and duration of FcRγ signals determines mast cell degranulation and survival.

Blood, 103 3093, 2004
Inhibitory adaptors in lymphocytes

Semin Immunol., in press, 2004
The quantity and duration of FcRγ signals determines mast cell degranulation and survival.

Blood, 103 3093, 2004
Negative feedback of T cell activation through inhibitory adaptors and co-stimulatory receptors.

Immunol. Rev., 192 143, 2003
Negative feedback of T cell activation through inhibitory adaptors and co-stimulatory receptors.

Immunol. Rev., 192 143, 2003
Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

T Yokosuka, K Takase, M Suzuki, Y Nakagawa, S Taki, H Takahashi, T Fujisawa, H Arase, T Saito

JOURNAL OF EXPERIMENTAL MEDICINE, 195(8) 991-1001, Apr, 2002
Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

T Yokosuka, K Takase, M Suzuki, Y Nakagawa, S Taki, H Takahashi, T Fujisawa, H Arase, T Saito

JOURNAL OF EXPERIMENTAL MEDICINE, 195(8) 991-1001, Apr, 2002
Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.

J. Immunol., 168(2) 541, 2002
Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.

J. Immunol., 168(2) 541, 2002
Azeredo da Silveira, S., Klkuchi, S., Fossati-Jimack, L., Moll, T., Saito, T., Verbeek, J. S., Botto, M., Walport, M. J., Carroll, M. and lzui S.: Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high ・・・

J. Exp. Med., 195(6):665-672, 2002
Snell, D. C., Schulte, V., Jarvis, G. E., Arase, K., Sakurai, D., Saito, T., Watson, S. P., and Nieswandt, B.: Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands.

Biochem. J., 368(Pt 1):293-300, 2002
Murata, Y., Yamashita, A., Saito, T., Sugamura, K. and Hamuro, J.: The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowl disease in Janus family tyrosine kinase 3-/- and IL-2Rγ-/- mice.

Int. Immunol., 14(6):627-636, 2002
Ioan-Facsinay, A., de Kimpe, S. J., Hellwig, S. M. M., van Lent, P. L., Hothuis, F. M. A., van Ojik, H. H., Sedlik, C., da Silveira, S. A., Gerber, J., de Jong, Y. F., Roozendaal, R., Aarden, L. A., van den Berg, W. B., Saito, T., Mosser, D., Amigorena・・・

Immunity, 16(3):391-402, 2002
Nishimura, K., Nakatsu, F., Kashiwagi, K., Ohno, H., Saito, T. and Igarashi, K.: Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development.

Genes Cells, 7(1): 41-47, 2002
Snell, D. C., Schulte, V., Jarvis, G. E., Arase, K., Sakurai, D., Saito, T., Watson, S. P., and Nieswandt, B.: Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands.

Biochem. J., 368(Pt 1):293-300, 2002
Azeredo da Silveira, S., Klkuchi, S., Fossati-Jimack, L., Moll, T., Saito, T., Verbeek, J. S., Botto, M., Walport, M. J., Carroll, M. and lzui S.: Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high ・・・

J. Exp. Med., 195(6):665-672, 2002
Redegeld, F. A., van der Heijden, M. W., Kool, M., Heijdra, B. M., Garssen, J., Kraneveld, A. D., van Loveren, H., Roholl, P., Saito, T., Verbeek, J. S., Claassens, J., Koster, A. S. and Nijkamp, F. P.: Immunoglobulin free light chains elicit immediate・・・

Nat. Med., 8 (7):694-71, 2002
Murata, Y., Yamashita, A., Saito, T., Sugamura, K. and Hamuro, J.: The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowl disease in Janus family tyrosine kinase 3-/- and IL-2Rγ-/- mice.

Int. Immunol., 14(6):627-636, 2002
Ioan-Facsinay, A., de Kimpe, S. J., Hellwig, S. M. M., van Lent, P. L., Hothuis, F. M. A., van Ojik, H. H., Sedlik, C., da Silveira, S. A., Gerber, J., de Jong, Y. F., Roozendaal, R., Aarden, L. A., van den Berg, W. B., Saito, T., Mosser, D., Amigorena・・・

Immunity, 16(3):391-402, 2002

Books and Other Publications

Oxidative stress by tumor-derived macrophages and abnormal structure of T-cell receptor complex.

Marcel Dekker, Inc. Redox Regulation of Cell Signaling and its Clinical Application, 1999
New components assembled with TCR or pre-TCR complex.

Monduzzi Editore S. p. A, The 10th International Congress of Immunology, 1998
Kinases and phosphatases in lymphocyte and neuronal signaling. "Regulation of T cell- and NK cell-acitivation by throsine-based signal motif." (共著)

Springer-Verlag, 1997
Weir's Handbook of Experimental Immunology, "T cell development and TCR signaling. "

Blackwell Science, Inc., 1996
Weir's Handbook of Experimental Immunology, "T cell development and TCR signaling. "

Blackwell Science, Inc., 1996
Welr's Handbook of Experimental Immunology, "T cell development and TCR signaling"(共著)

Blackwell Scientific Publications, 1996
Preferential usage of the Fc receptor γ chain in the T cell antigen receptor complex by γ/δ T cells localized in epithelia.

J. Exp. Med., 1994

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Research History

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