2001年3月30日
Identification of a tumor-associated contact-dependent activity which reversibly downregulates cytolytic function of CD8+ T cells
Cancer Immunity
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- 巻
- 1
- 号
- 開始ページ
- 1
- 終了ページ
- 14
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- Academy of Cancer Immunology
Tumors elicit an immune response in hosts and yet, paradoxically, often grow progressively with fatal consequences. This phenomenon has been attributed to the possible expression by tumor cells of immunomodulatory factors that overcome the anti-tumor effector functions of both specific and non-specific immune cells. This study reports on the ability of the methylcholanthrene- induced fibrosarcoma, Meth A, as well as other tumors of varied histological origins to downregulate the lytic activity of CD8+ T cells. The suppressive activity is contact-dependent and reversible. As tumor-bearing hosts are rarely immunosuppressed systemically, these findings may explain how local events within the tumor bed subvert the specific anti-tumor immune response.
- リンク情報
- ID情報
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- ISSN : 1424-9634
- PubMed ID : 12747766
- SCOPUS ID : 3142618477