2010 - 2012
Analysis of a role of Hsp90α in antigen cross presentation
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 22501027
- Japan Grant Number (JGN)
- JP22501027
- Grant amount
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- (Total)
- 4,420,000 Japanese Yen
- (Direct funding)
- 3,400,000 Japanese Yen
- (Indirect funding)
- 1,020,000 Japanese Yen
Analysis of a role of Hsp90α in antigen cross presentation In antigen cross-presentation, dendritic cells (DCs) take up extracellular antigens (Ag) and translocate them from the endosome to the cytosol for proteasomal degradation. The molecules responsible for Ag translocation are unknown. By using Hsp90α KO mice, we demonstrated that HSP90 is essential in pulling endosomal Ag out into the cytosol.
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- ID information
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- Grant number : 22501027
- Japan Grant Number (JGN) : JP22501027