HOTTA Kikuko

J-GLOBAL         Last updated: Apr 19, 2019 at 15:17
 
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Name
HOTTA Kikuko
Affiliation
Kyoto University
Section
Graduate School of Medicine
Research funding number
30360639
ORCID ID
https://orcid.org/0000-0003-2427-6354

Academic & Professional Experience

 
Jun 2015
 - 
Today
Associate Professor, Department of Medical Innovation, Osaka University Hospital
 
Apr 2010
 - 
Mar 2015
Assistant Professor, Pharmacogenomics, Kyoto University Graduate School of Medicine
 
Apr 2008
 - 
Mar 2010
RIKEN Yokohama Institute
 

Education

 
Apr 1983
 - 
Mar 1989
Medical School, Osaka University
 

Published Papers

 
Sato S, Morimoto T, Hotta K, Fujikado T, Nishida K
Human genome variation   6 14   2019   [Refereed]
Hotta K, Kitamoto A, Kitamoto T, Ogawa Y, Honda Y, Kessoku T, Yoneda M, Imajo K, Tomeno W, Saito S, Nakajima A
Scientific reports   8(1) 13567   Sep 2018   [Refereed]
Hotta K, Kitamoto T, Kitamoto A, Ogawa Y, Honda Y, Kessoku T, Yoneda M, Imajo K, Tomeno W, Saito S, Nakajima A
Hepatology research : the official journal of the Japan Society of Hepatology   48(3) E320-E334   Feb 2018   [Refereed]
Hotta K, Kikuchi M, Kitamoto T, Kitamoto A, Ogawa Y, Honda Y, Kessoku T, Kobayashi K, Yoneda M, Imajo K, Tomeno W, Nakaya A, Suzuki Y, Saito S, Nakajima A
Hepatology research : the official journal of the Japan Society of Hepatology   47(13) 1445-1458   Feb 2017   [Refereed]
Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A, Hotta K
Hepatology research : the official journal of the Japan Society of Hepatology   46(10) 1011-1018   Sep 2016   [Refereed]
Kitamoto A, Kitamoto T, Nakamura T, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K
Journal of atherosclerosis and thrombosis   23(3) 309-319   Oct 2015   [Refereed]
Kan H, Hyogo H, Ochi H, Hotta K, Fukuhara T, Kobayashi T, Naeshiro N, Honda Y, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Chayama K
Hepatology research : the official journal of the Japan Society of Hepatology   46(3) E146-53   Jul 2015   [Refereed]
Kitamoto T, Kitamoto A, Ogawa Y, Honda Y, Imajo K, Saito S, Yoneda M, Nakamura T, Nakajima A, Hotta K
Journal of hepatology   63(2) 494-502   Mar 2015   [Refereed]
Kitamoto A, Kitamoto T, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K
Endocrine journal   62(6) 513-521   2015   [Refereed]
Matsuo T, Nakata Y, Hotta K, Tanaka K
Metabolism: clinical and experimental   63(7) 912-917   Jul 2014   [Refereed]
Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K
Journal of human genetics   59 241-246   May 2014   [Refereed]
He D, Fu M, Miao S, Hotta K, Chandak GR, Xi B
Metabolism: clinical and experimental   63 633-639   May 2014   [Refereed]
Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K
Endocrine journal   61(7) 683-689   May 2014   [Refereed]
Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Nakamura T, Teranishi H, Mizusawa S, Ueno T, Chayama K, Nakajima A, Nakao K, Sekine A, Hotta K
Human genetics   132(7) 783-792   Jul 2013   [Refereed]
Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A, Hotta K
Endocrine journal   60(8) 991-1000   2013   [Refereed]
K. Hotta; A. Kitamoto; T. Kitamoto; S. Mizusawa; H. Teranishi; R. So; T. Matsuo; Y. Nakata; H. Hyogo; H. Ochi; T. Nakamura; S. Kamohara; N. Miyatake; K. Kotani; N. Itoh; I. Mineo; J. Wada; M. Yoneda; A. Nakajima; T. Funahashi; S. Miyazaki; K. Tokunaga; H. Masuzaki; T. Ueno; K. Chayama; K. Hamaguchi; K. Yamada; T. Hanafusa; S. Oikawa; T. Sakata; K. Tanaka; Y. Matsuzawa; K. Nakao; A. Sekine
Journal of Atherosclerosis and Thrombosis   20(4) 336-350   2013   [Refereed]
Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y
Biochemical and biophysical research communications   425 560-564   Aug 2012   [Refereed]
Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Iseda I, Matsushita Y, Miyatake N, McDonald JF, Hotta K, Makino H
The Journal of clinical endocrinology and metabolism   97(7) E1202-7   Jul 2012   [Refereed]
Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A
Journal of human genetics   57(5) 305-310   May 2012   [Refereed]
Matsuo T, Nakata Y, Murotake Y, Hotta K, Tanaka K
Obesity (Silver Spring, Md.)   20(5) 1122-1126   May 2012   [Refereed]
H. Li; T.O. Kilpeläinen; C. Liu; J. Zhu; Y. Liu; C. Hu; Z. Yang; W. Zhang; W. Bao; S. Cha; Y. Wu; T. Yang; A. Sekine; B.Y. Choi; C.S. Yajnik; D. Zhou; F. Takeuchi; K. Yamamoto; J.C. Chan; K.R. Mani; L.F. Been; M. Imamura; E. Nakashima; N. Lee; T. Fujisawa; S. Karasawa; W. Wen; C.V. Joglekar; W. Lu; Y. Chang; Y. Xiang; Y. Gao; S. Liu; Y. Song; S.H. Kwak; H.D. Shin; K.S. Park; C.H.D. Fall; J.Y. Kim; P.C. Sham; K.S.L. Lam; W. Zheng; X. Shu; H. Deng; H. Ikegami; G.V. Krishnaveni; D.K. Sanghera; L. Chuang; L. Liu; R. Hu; Y. Kim; M. Daimon; K. Hotta; W. Jia; J.S. Kooner; J.C. Chambers; G.R. Chandak; R.C. Ma; S. Maeda; R. Dorajoo; M. Yokota; R. Takayanagi; N. Kato; X. Lin; R.J.F. Loos
Diabetologia   55(4) 981-995   Apr 2012   [Refereed]
Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A
Journal of human genetics   57(1) 46-51   Jan 2012   [Refereed]
Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A
Journal of human genetics   56(10) 716-719   Oct 2011   [Refereed]
Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Nakao K, Sekine A
Journal of human genetics   56(9) 647-651   Sep 2011   [Refereed]
Hotta K, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Chayama K, Nakajima A, Nakao K, Sekine A
BMC medical genetics   11(1) 172   Dec 2010   [Refereed]
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Masuzaki H, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Nakamura Y, Kamatani N
Journal of human genetics   55(11) 738-742   Nov 2010   [Refereed]
Lee YS, Choi JW, Hwang I, Lee JW, Lee JH, Kim AY, Huh JY, Koh YJ, Koh GY, Son HJ, Masuzaki H, Hotta K, Alfadda AA, Kim JB
The Journal of biological chemistry   285(29) 22174-22185   Jul 2010   [Refereed]
Yoneda M, Nozaki Y, Endo H, Mawatari H, Iida H, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Kobayashi N, Kubota K, Saito S, Maeyama S, Hotta K, Nakajima A
Digestive diseases and sciences   55(3) 808-814   Mar 2010   [Refereed]
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y
Journal of human genetics   54 727-731   Dec 2009   [Refereed]
Matsuo T, Nakata Y, Katayama Y, Iemitsu M, Maeda S, Okura T, Kim MK, Ohkubo H, Hotta K, Tanaka K
Obesity (Silver Spring, Md.)   17(10) 1924-1931   Oct 2009   [Refereed]
Yoneda M, Hotta K, Nozaki Y, Endo H, Tomeno W, Watanabe S, Hosono K, Mawatari H, Iida H, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Kubota K, Shimamura T, Saito S, Maeyama S, Wada K, Nakajima A
Hepatology research : the official journal of the Japan Society of Hepatology   39(10) 963-971   Oct 2009   [Refereed]
Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A
Liver international : official journal of the International Association for the Study of the Liver   29(7) 1078-1085   Aug 2009   [Refereed]
Hotta K, Hosaka M, Tanabe A, Takeuchi T
The Journal of endocrinology   202(1) 111-121   Jul 2009   [Refereed]
Hotta K, Nakamura T, Takasaki J, Takahashi H, Takahashi A, Nakata Y, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y
Journal of human genetics   54(4) 230-235   Apr 2009   [Refereed]
Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, Higurashi T, Uchiyama T, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Abe Y, Kubota K, Saito S, Kobayashi N, Yamaguchi N, Maeyama S, Yamamoto S, Tsutsumi S, Aburatani H, Wada K, Hotta K, Nakajima A
Hepatology research : the official journal of the Japan Society of Hepatology   38(12) 1204-1212   Dec 2008   [Refereed]
Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Hosono K, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A
BMC gastroenterology   8 27   Jun 2008   [Refereed]
Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
Journal of human genetics   53(9) 857-862   2008   [Refereed]
Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y
Journal of human genetics   53(6) 546-553   2008   [Refereed]
Yanagiya T, Tanabe A, Iida A, Saito S, Sekine A, Takahashi A, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K
Human molecular genetics   16(24) 3017-3026   Dec 2007   [Refereed]
Yanagiya T, Tanabe A, Hotta K
Obesity (Silver Spring, Md.)   15(3) 572-582   Mar 2007   [Refereed]
Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K
The Journal of clinical endocrinology and metabolism   92(3) 1145-1154   Mar 2007   [Refereed]
M. Yoneda; H. Endo; Y. Nozaki; A. Tomimoto; T. Fujisawa; K. Fujita; K. Yoneda; H. Takahashi; S. Saito; T. Iwasaki; S. Yamamoto; S. Tsutsumi; H. Aburatani; K. Wada; K. Hotta; A. Nakajima
Journal of Pharmacological Sciences   105(2) 151-156   2007   [Refereed]
Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, Nakamura T, Shimomura I, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y
Circulation   105 2893-2898   Jun 2002   [Refereed]
Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, Takeda J, Funahashi T, Matsuzawa Y
The Journal of biological chemistry   277 1586-1592   Jan 2002   [Refereed]
Kishida K, Shimomura I, Nishizawa H, Maeda N, Kuriyama H, Kondo H, Matsuda M, Nagaretani H, Ouchi N, Hotta K, Kihara S, Kadowaki T, Funahashi T, Matsuzawa Y
The Journal of biological chemistry   276 48572-48579   Dec 2001   [Refereed]
Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance.
Nagaretani H, Nakamura T, Funahashi T, Kotani K, Miyanaga M, Tokunaga K, Takahashi M, Nishizawa H, Kishida K, Kuriyama H, Hotta K, Yamashita S, Matsuzawa Y
Diabetes care   24 2127-2133   Dec 2001   [Refereed]
Nakamura T, Funahashi T, Yamashita S, Nishida M, Nishida Y, Takahashi M, Hotta K, Kuriyama H, Kihara S, Ohuchi N, Nishimura T, Kishino BI, Ishikawa K, Kawamoto T, Tokunaga K, Nakagawa C, Mineo I, Watanabe F, Tarui S, Matsuzawa Y
Diabetes research and clinical practice   54 181-190   Dec 2001   [Refereed]
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y
Diabetes   50 2094-2099   Sep 2001   [Refereed]
Hotta K, Funahashi T, Matsukawa Y, Takahashi M, Nishizawa H, Kishida K, Matsuda M, Kuriyama H, Kihara S, Nakamura T, Tochino Y, Bodkin NL, Hansen BC, Matsuzawa Y
The Journal of biological chemistry   276 34089-34097   Sep 2001   [Refereed]
Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA
The Journal of clinical endocrinology and metabolism   86 1930-1935   May 2001   [Refereed]
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.
Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y
Diabetes   50 1126-1133   May 2001   [Refereed]
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages.
Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y, Yamashita S, Funahashi T, Matsuzawa Y
Circulation   103 1057-1063   Feb 2001   [Refereed]
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway.
Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
Circulation   102 1296-1301   Sep 2000   [Refereed]
Genomic structure and mutations in adipose-specific gene, adiponectin.
Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity   24 861-868   Jul 2000   [Refereed]
Kishida K, Kuriyama H, Funahashi T, Shimomura I, Kihara S, Ouchi N, Nishida M, Nishizawa H, Matsuda M, Takahashi M, Hotta K, Nakamura T, Yamashita S, Tochino Y, Matsuzawa Y
The Journal of biological chemistry   275 20896-20902   Jul 2000   [Refereed]
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y
Arteriosclerosis, thrombosis, and vascular biology   20 1595-1599   Jun 2000   [Refereed]
Hotta K, Matsukawa Y, Nishida M, Kotani K, Takahashi M, Kuriyama H, Nakamura T, Wada K, Yamashita S, Funahashi T, Matsuzawa Y
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme   32 33-34   Jan 2000   [Refereed]
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
Circulation   100 2473-2476   Dec 1999   [Refereed]
Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPARgamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys.
Hotta K, Bodkin NL, Gustafson TA, Yoshioka S, Ortmeyer HK, Hansen BC
The journals of gerontology. Series A, Biological sciences and medical sciences   54 B183-8   May 1999   [Refereed]
Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y
Biochemical and biophysical research communications   257 79-83   Apr 1999   [Refereed]
Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys.
Hotta K, Gustafson TA, Yoshioka S, Ortmeyer HK, Bodkin NL, Hansen BC
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity   22 1000-1010   Oct 1998   [Refereed]
Monkey leptin receptor mRNA: sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys.
Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Hansen BC
Obesity research   6 353-360   Sep 1998   [Refereed]
Kuwajima M, Lu K, Sei M, Ono A, Hayashi M, Ishiguro K, Ozaki K, Hotta K, Okita K, Murakami T, Miyagawa J, Narama I, Nikaido H, Hayakawa J, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y, Shima K
Journal of molecular and cellular cardiology   30 773-781   Apr 1998   [Refereed]
Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.
Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C
Molecular and cellular biology   17 6633-6644   Nov 1997   [Refereed]
Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Nicolson MA, Hansen BC
The Journal of biological chemistry   271 25327-25331   Oct 1996   [Refereed]
O'Neill TJ, Rose DW, Pillay TS, Hotta K, Olefsky JM, Gustafson TA
The Journal of biological chemistry   271 22506-22513   Sep 1996   [Refereed]
Hotta K, Kuwajima M, Ono A, Nakajima H, Horikawa Y, Miyagawa J, Namba M, Hanafusa T, Horiuchi M, Nikaido H, Hayakawa J, Saheki T, Kono N, Noguchi T, Matsuzawa Y
Diabetes research and clinical practice   32 117-123   May 1996   [Refereed]
Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Otsuka Long-Evans Tokushima fatty rats with spontanteous long-term hyperglycemia.
Hotta K, Kuwajima M, Ono A, Nakajima H, Shingu R, Miyagawa J, Namba M, Hanafusa T, Noguchi T, Kono N, Matsuzawa Y
Biochimica et biophysica acta   1289 145-149   Feb 1996   [Refereed]
Hotta K, Kuwajima M, Ono A, Uenaka R, Nakajima H, Miyagawa J, Namba M, Hanafusa T, Horiuchi M, Nikaido H, Hayakawa J, Kono N, Saheki T, Matsuzawa Y
Biochimica et biophysica acta   1289 131-135   Feb 1996   [Refereed]
Hotta K, Nakajima H, Yamasaki T, Hamaguchi T, Kuwajima M, Noguchi T, Tanaka T, Kono N, Tarui S
European journal of biochemistry / FEBS   202 293-298   Dec 1991   [Refereed]
Yamasaki T, Nakajima H, Kono N, Hotta K, Yamada K, Imai E, Kuwajima M, Noguchi T, Tanaka T, Tarui S
Gene   104 277-282   Aug 1991   [Refereed]
A genetic defect in muscle phosphofructokinase deficiency, a typical clinical entity presenting myogenic hyperuricemia.
Nakajima H, Kono N, Yamasaki T, Hotta K, Kawachi M, Hamaguchi T, Nishimura T, Mineo I, Kuwajima M, Noguchi T
Advances in experimental medicine and biology   309B 141-144   1991   [Refereed]
Nakajima H, Kono N, Yamasaki T, Hamaguchi T, Hotta K, Kuwajima M, Noguchi T, Tanaka T, Tarui S
Biochemical and biophysical research communications   173 1317-1321   Dec 1990   [Refereed]
Genetic defect in muscle phosphofructokinase deficiency. Abnormal splicing of the muscle phosphofructokinase gene due to a point mutation at the 5'-splice site.
Nakajima H, Kono N, Yamasaki T, Hotta K, Kawachi M, Kuwajima M, Noguchi T, Tanaka T, Tarui S
The Journal of biological chemistry   265 9392-9395   Jun 1990   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2011 - 2012    Investigator(s): Takuya KITAMOTO
For GWAS, 372 Japanese NAFLD subjects and 934 control individuals were analyzed. For replication studies, 172 NAFLD and 1012 control subjects were monitored. Rs738409 in the PNPLA3 gene was most strongly associated with NAFLD. Rs2896019, and rs381...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2011 - 2012    Investigator(s): Aya KITAMOTO
SNPs in the SH2B1, FTO, NUDT3, and LYPLAL1 genes were associated with fat distribution. We performed genome-wide association study (GWAS) and identified the genomic region including PNPLA3, SAMM50, and PARVB genes as susceptible locus for the deve...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Kikuko HOTTA
We identified SCG2, which bound to SCG3 and facilitated the aggregation of NPY, orexin and MCH. We found that variations in the SEC16B, TMEM18, GNPDA2, BDNF, and FAIM2 genes were associated with obesity in the Japanese population. We also found th...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Kikuko HOTTA
SNPs in the obesity-related gene 3, that is myotubularin-related protein 9 (MTMR9) gene, was associated with obesity and hypertension. The mRNA with risk alleles of SNPs existed in 37UTR was less stable that that without risk alleles, suggesting t...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Kikuko HOTTA
Gap-junctional communication (GJC) plays critical roles in cell growth and differentiation. Several studies have demonstrated the involvement of GJC in myogenesis and osteogenesis, however, the role of GJC in adipogenesis has not been fully studie...