Usui Takeo

J-GLOBAL         Last updated: Oct 17, 2019 at 02:50
Usui Takeo
University of Tsukuba
Faculty of Life and Environmental Sciences
Job title

Research Areas


Academic & Professional Experience

Apr 1994
Sep 1995
Research Fellow, JSPS
Oct 1995
Mar 2004
Researcher, RIKEN institute
Oct 2001
Feb 2002
Postdoctrol fellow, Beatson Cancer Research Institute (Glasgow, Great Britain)
Mar 2002
Apr 2003
Postdoctrol fellow, Paterson Cancer Research Institute (Manchester, Great Britain)
Apr 2005
Aug 2006
Senior Researcher, RIKEN institute


Apr 1986
Mar 1990
Faculty of Agriculture, The University of Tokyo
Apr 1990
Mar 1992
Graduate School, Division of Agricultural Science, The University of Tokyo
Apr 1992
Mar 1995
Graduate School, Division of Agricultural Science, The University of Tokyo

Awards & Honors

Mar 2012
Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry, Japan Society for Bioscience, Biotechnology, and Agrochemistry
Mar 2007
Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry, Japanese Society for Bioscience, Biotechnology, and Agrochemistry

Published Papers

Mukaiyama, Minagi;Yamasaki, Yohei;Usui, Takeo;Nagumo, Yoko
FEBS letters   593(16) 2250-2260   Jun 2019   [Refereed]
The transient receptor potential V4 channel (TRPV4) is responsive to a variety of physical and chemical stimuli, including a synthetic agonist GSK1016790A (GSK). Here, we show that TRPV4 is functionally expressed in, and that GSK induces the rever...
Hamada, Keisuke;Naito, Akari;Kanesaki, Yu;Hamaguchi, Yu;Kasahara, Koji;Omura, Noriko;Taguchi, Akihiro;Hayashi, Yoshio;Usui, Takeo
Bioscience, biotechnology, and biochemistry   Epub 1-4   Jun 2019
In this study, we found that dipeptide transporter Ptr2p is the putative transporter of read-through compounds (+)-negamycin derivatives TCP-126 and TCP-112, in budding yeast. Ptr2p expression and activity were correlated with the TCP-112 sensitiv...
Sakai, Katsuyuki; Suga, Takuya; Iwatsuki, Masato; Chinen, Takumi; Nonaka, Kenichi; Usui, Takeo; Asami, Yukihiro; Ōmura, Satoshi; Shiomi, Kazuro
The Journal of antibiotics   71(12) 1031-1035   Sep 2018   [Refereed]
Secondary metabolites of microorganisms have proven to be an excellent source of drugs. We isolated a new antibiotic, named pestiocandin (1), from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI-7473, using a multidrug-sensitive ...
Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay
Sakai, Katsuyuki;Hirose, Tomoyasu;Iwatsuki, Masato;Chinen, Takumi;Kimura, Toru;Suga, Takuya;Nonaka, Kenichi;Nakashima, Takuji;Sunazuka, Toshiaki;Usui, Takeo;Asami, Yukihiro;O Mura, Satoshi;Shiomi, Kazuro
Journal of natural products   81 1604-1609   Jul 2018   [Refereed]
Symposium on the Chemistry of Natural Products, symposium papers   56(0) Poster78   2014
<p>V-ATPase is a ubiquitous proton pump, which is correlated with an increasing number of life-style diseases such as osteopetrosis and cancer. Therefore, its inhibitors play a pivotal role in understanding these diseases. Bafilomycin (Baf, 1), is...

Books etc

The Yeast Role in Medical Applications
Chinen, Takumi;Hamada, Keisuke;Taguchi, Akihiro;Asami, Yukihiro;Shiomi, Kazuro;Hayashi, Yoshio;Usui, Takeo (Part:Contributor, Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics)
Jan 2018   
Bioprobes (second edition)
Hiroyuki, Koshino;Usui, Takeo (Part:Contributor, Bioprobes at a Glance)
Springer Japan KK   Apr 2017   
Mar 1995   
吉田稔;臼井健郎 (Part:Supervisor)
Cell Science   Jan 1992   
長田裕之;臼井健郎;掛谷秀昭 (Part:Supervisor)
バイオインダストリー   Jan 1998   

Conference Activities & Talks

アクチンの FD-891 結合部位検討
吉田 香里;吉田 英輝;江口 正;工藤 史貴;臼井, 健郎
日本農芸化学会関東支部2017年度大会   2 Sep 2017   
薬剤共処理による γ- チューブリン特異的阻害剤 gatastatin の細胞毒性増強
恵比須 春菜;早川 一郎;木越 英夫;臼井, 健郎
日本農芸化学会関東支部2017年度大会   2 Sep 2017   
酵母を用いた negamycin 類縁体によるリードスルー活性の作用機構解析
濱田 圭佑;内藤 あかり;兼崎 友;笠原 浩司;林 良雄;臼井, 健郎
日本農芸化学会関東支部2017年度大会   2 Sep 2017   
抗腫瘍活性物質 vicenistatin 耐性に関与する遺伝子の同定
工藤 駿;知念 巧実;兼崎 友;笠原 浩司;工藤 史貴;江口 正;臼井, 健郎
日本農芸化学会関東支部2017年度大会   2 Sep 2017   
非侵襲的薬剤投与法を可能にする上皮タイトジャンクション可逆的開口剤の開発 [Invited]
第13回農芸化学研究企画賞受賞者による最終報告会   16 Mar 2018   


6430246 : 微小管重合阻害剤
臼井, 健郎;木越 英夫;早川 一郎;知念 拓実;塩田 秀也
6311097 : 微小管脱重合剤
臼井, 健郎;林 良雄;薬師寺文華;高山健太郎
6311097 : 微小管脱重合剤
林, 良雄;薬師寺文華;高山健太郎;林, 良樹;臼井, 健郎