KAKEYA Hideaki

J-GLOBAL         Last updated: Jun 16, 2019 at 18:08
 
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Name
KAKEYA Hideaki
Affiliation
Kyoto University
Section
Graduate School of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Division of Bioinformatics and Chemical Genomics
Job title
Professor,Professor
Degree
Ph.D.
ORCID ID
0000-0002-4293-7331

Research Areas

 
 

Academic & Professional Experience

 
1994
   
 
:Research Scientist, RIKEN Institute
 
1998
 - 
2000
:Visiting Scientist, MIT
 
2003
   
 
:Senior Scientist, Team Leader, RIKEN Institute
 
2007
   
 
:Professor, Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemcial Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
 
 
   
 
Visiting Professor, RIKEN Institute
 

Education

 
 
 - 
1994
Keio University
 

Awards & Honors

 
2006
The Sumiki Umezawa Memorial Awards, Japan Antibiotics research Association
 
2006
The Awards, Alumni Association of Faculty of Science and Technology, Keio University
 
2002
Research Promotion Award, Japan Society for Bioscience, Biotechnology, and Agrochemistry
 
1999
Young Investigators Awards of the Japanese Association for Molecular Target Therapy of Cancer
 

Published Papers

 
Ishikawa F, Tanabe G, Kakeya H
Current topics in microbiology and immunology   420 321-349   Sep 2018   [Refereed]
Takahashi N, Hayashi K, Nakagawa Y, Furutani Y, Toguchi M, Shiozaki-Sato Y, Sudoh M, Kojima S, Kakeya H
Bioorganic & medicinal chemistry   27(3) 470-478   Feb 2019   [Refereed]
Lu S, Nishimura S, Takenaka K, Ito M, Kato T, Kakeya H
Organic letters   20(15) 4406-4410   Aug 2018   [Refereed]
Ozaki T, Sugiyama R, Shimomura M, Nishimura S, Asamizu S, Katsuyama Y, Kakeya H, Onaka H
Organic & biomolecular chemistry   17(9) 2370-2378   Feb 2019   [Refereed]
Cornelio K, Espiritu RA, Hanashima S, Todokoro Y, Malabed R, Kinoshita M, Matsumori N, Murata M, Nishimura S, Kakeya H, Yoshida M, Matsunaga S
Biochimica et biophysica acta. Biomembranes   1861(1) 228-235   Jul 2018   [Refereed]
Furutani Y, Toguchi M, Shiozaki-Sato Y, Qin XY, Ebisui E, Higuchi S, Sudoh M, Suzuki H, Takahashi N, Watashi K, Wakita T, Kakeya H, Kojima S
PloS one   14(6) e0216139   2019   [Refereed]
Ozawa H, Imaizumi A, Sumi Y, Hashimoto T, Kanai M, Makino Y, Tsuda T, Takahashi N, Kakeya H.
Biological and Pharmaceutical Bulletin   40(9) 1515-1524   2017   [Refereed]
Sunagawa Y, Funamoto M, Sono S, Shimizu K, Shimizu S, Genpei M, Miyazaki Y, Katanasaka Y, Morimoto E, Ueno M, Komiyama M, Kakeya H, Wada H, Hasegawa K, Morimoto T
Journal of pharmacological sciences   136(4) 212-217   Apr 2018   [Refereed]
Genpei M, Sunagawa Y, Funamoto M, Shimizu K, Miyazaki Y, Katanasaka Y, Takahashi N, Kakeya H, Wada H, Hasegawa K, Morimoto T
European cardiology   13(2) 136   Dec 2018   [Refereed]
Konno S, Ishikawa F, Suzuki T, Dohmae N, Kakeya H, Tanabe G.
ChemBioChem   18(18) 1855-1862   Sep 2017   [Refereed]
Ishikawa F, Kasai S, Kakeya H, Tanabe G
Chembiochem : a European journal of chemical biology   18(22) 2199-2204   Nov 2017   [Refereed]
Lu S, Nishimura S, Ito M, Kato T, Kakeya H.
Journal of Antibiotics   70(5) 718-720   May 2017   [Refereed]
Genpei M, Sunagawa Y, Funamoto M, Shimizu K, Miyazaki Y, Katanasaka Y, Takahashi N, Kakeya H, Wada H, Hasegawa K, Morimoto T
European cardiology   12(2) 107   Dec 2017   [Refereed]
Ishikawa F, Sugimoto H, Kakeya H
Chembiochem : a European journal of chemical biology   17(22) 2137-2142   Nov 2016   [Refereed]
Matsumoto Y, Hibino K, Yonaga M, Kakeya H, Hayashi Y.
Organic Letters   18(14) 3382-3385   Jul 2016   [Refereed]
Cornelio K, Espiritu RA, Todokoro Y, Hanashima S, Kinoshita M, Matsumori N, Murata M, Nishimura S, Kakeya H, Yoshida M, Matsunaga S
Bioorganic & medicinal chemistry   24(21) 5235-5242   Nov 2016   [Refereed]
Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H.
Angewandte Chemie - International Edition   55(35) 10278-10282   Aug 2016   [Refereed]
Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, Harada H
Oncotarget   7(40) 65837-65848   Oct 2016   [Refereed]
Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.
International Journal of COPD   11(1) 2029-2034   2016   [Refereed]
Kasai S, Ishikawa F, Suzuki T, Dohmae N, Kakeya H.
Chemical Communications   52(98) 14129-14132   Dec 2016   [Refereed]
Kanoh N, Itoh S, Fujita K, Sakanishi K, Sugiyama R, Terajima Y, Iwabuchi Y, Nishimura S, Kakeya H.
Chemistry - A European Journal   22(25) 8586-8595   2016   [Refereed]
Ishikawa F, Kakeya H.
ChemBioChem   17(6) 474-478   2016   [Refereed]
Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A, Kakeya H
Journal of biochemistry      Jun 2015   [Refereed]
Ishikawa F, Konno S, Suzuki T, Dohmae N, Kakeya H
ACS chemical biology      Jun 2015   [Refereed]
Kishimoto S, Nishimura S, Hatano M, Igarashi M, Kakeya H
The Journal of organic chemistry   80(12) 6076-6082   Jun 2015   [Refereed]
Lu S, Nishimura S, Hirai G, Ito M, Kawahara T, Izumikawa M, Sodeoka M, Shin-ya K, Tsuchida T, Kakeya H
Chemical communications (Cambridge, England)   51(38) 8074-8077   May 2015   [Refereed]
Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H
Organic letters   17(8) 1918-1921   Apr 2015   [Refereed]
Yasuda Y, Arakawa T, Nawata Y, Shimada S, Oishi S, Fujii N, Nishimura S, Hattori A, Kakeya H
Bioorganic & medicinal chemistry   23(8) 1776-1787   Apr 2015   [Refereed]
Konno S, Ishikawa F, Suzuki T, Dohmae N, Burkart MD, Kakeya H
Chemical communications (Cambridge, England)   51(12) 2262-2265   Feb 2015   [Refereed]
Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H
Nature communications   6 6153   Jan 2015   [Refereed]
Tsunematsu Y, Nishimura S, Hattori A, Oishi S, Fujii N, Kakeya H
Organic letters   17(2) 258-261   Jan 2015   [Refereed]
Sunagawa Y, Hirano S, Katanasaka Y, Miyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T
Journal of nutritional science and vitaminology   61(1) 37-44   2015   [Refereed]
Nishimura S, Tokukura M, Ochi J, Yoshida M, Kakeya H
Chemistry & biology   21(12) 1690-1699   Dec 2014   [Refereed]
Fujita K, Ishikawa F, Kakeya H
Journal of natural products   77(12) 2707-2710   Dec 2014   [Refereed]
Kishimoto S, Nishimura S, Hattori A, Tsujimoto M, Hatano M, Igarashi M, Kakeya H
Organic letters   16(23) 6108-6111   Dec 2014   [Refereed]
Yoshimura A, Kishimoto S, Nishimura S, Otsuka S, Sakai Y, Hattori A, Kakeya H
The Journal of organic chemistry   79(15) 6858-6867   Aug 2014   [Refereed]
K. Miyamoto; F. Ishikawa; S. Nakamura; Y. Hayashi; I. Nakanishi; H. Kakeya
Bioorganic and Medicinal Chemistry   22(8) 2517-2528   Apr 2014   [Refereed]
R. Sugiyama; S. Nishimura; N. Matsumori; Y. Tsunematsu; A. Hattori; H. Kakeya
Journal of the American Chemical Society   136(14) 5209-5212   Apr 2014   [Refereed]
F. Ishikawa; H. Kakeya
Bioorganic and Medicinal Chemistry Letters   24(3) 865-869   Feb 2014   [Refereed]
KOJIMA SOICHI, KAKEYA HIDEAKI, SUDO MASAYUKI, YOSHIMOTO TAKAYUKI, SAITO TAMIO, USUI KENGO, YAMAGUCHI TOKIO, FURUTANI YUTAKA, NAKAMURA AKIKO, INOUE IKUYO, SHIMADA SAYAKA, YUKI MIZUE, YAMAMOTO YUKA, SHIN KAN'YO, TSUKUDA SENKO, SAKATA KOTARO
次世代生命基盤技術を用いたB型肝炎制圧のための創薬研究 平成25年度総括・分担研究報告書   14-19   2014
K. Sakanishi; S. Itoh; R. Sugiyama; S. Nishimura; H. Kakeya; Y. Iwabuchi; N. Kanoh
European Journal of Organic Chemistry   2014(7) 1376-1380   2014   [Refereed]
Sunagawa Y, Sono S, Katanasaka Y, Funamoto M, Hirano S, Miyazaki Y, Hojo Y, Suzuki H, Morimoto E, Marui A, Sakata R, Ueno M, Kakeya H, Wada H, Hasegawa K, Morimoto T
Journal of pharmacological sciences   126(4) 329-336   2014   [Refereed]
KASAI SHOTA, NISHIMURA SHIN'ICHI, KAKEYA HIDEAKI
がん分子標的治療   11(1) 59-64   Nov 2013
J.-M. Fustin; M. Doi; Y. Yamaguchi; H. Hida; S. Nishimura; M. Yoshida; T. Isagawa; M.S. Morioka; H. Kakeya; I. Manabe; H. Okamura
Cell   155(4) 793-806   Nov 2013   [Refereed]
Y. Ohno; A. Hattori; T. Yoshiki; H. Kakeya
Journal of Biochemistry   154(4) 355-362   Oct 2013   [Refereed]
YAMORI TAKAO, UEHARA YOSHIMASA, FUKAZAWA SHUHO, YOSHIDA MINORU, IMOTO MASAYA, SEIMIYA HIROYUKI, MASHIMA TETSUO, MIZUKAMI TAMIO, KAWADA MANABU, OSADA HIROYUKI, DAN SHINGO, MATSUURA MASAAKI, KAKEYA HIDEAKI, TOMIDA AKIHIRO
癌と化学療法   40(Supplement 1) 115-146   Apr 2013
[The 15th result of screening for antineoplastic agents].
T. Yamori; Y. Uehara; H. Fukazawa; M. Yoshida; M. Imoto; H. Kiyomiya; T. Mashima; T. Manakami; M. Kawata; H. Nagata; S. Dan; M. Matsuura; H. Kakeya; A. Tomita
Gan to kagaku ryoho. Cancer & chemotherapy   40 Suppl 1 116-147   Apr 2013   [Refereed]
R.A. Espiritu; N. Matsumori; M. Murata; S. Nishimura; H. Kakeya; S. Matsunaga; M. Yoshida
Biochemistry   52(14) 2410-2418   Apr 2013   [Refereed]
Y. Nagamoto; A. Hattori; H. Kakeya; Y. Takemoto; K. Takasu
Chemical Communications   49(26) 2622-2624   Apr 2013   [Refereed]
S. Otsuki; S. Nishimura; H. Takabatake; K. Nakajima; Y. Takasu; T. Yagura; Y. Sakai; A. Hattori; H. Kakeya
Bioorganic and Medicinal Chemistry Letters   23(6) 1608-1611   Mar 2013   [Refereed]
KAKEYA HIDEAKI
医科学応用研究財団研究報告(CD-ROM)   30 235-237   2013
R. Sugiyama; S. Nishimura; H. Kakeya
Tetrahedron Letters   54(12) 1531-1533   2013   [Refereed]
S. Nishimura; K. Ishii; K. Iwamoto; Y. Arita; S. Matsunaga; Y. Ohno-Iwashita; S.B. Sato; H. Kakeya; T. Kobayashi; M. Yoshida
PLoS ONE   8(12) e83716   2013   [Refereed]
T. Morimoto; Y. Sunagawa; Y. Katanasaka; S. Hirano; M. Namiki; Y. Watanabe; H. Suzuki; O. Doi; K. Suzuki; M. Yamauchi; T. Yokoji; E. Miyoshi-Morimoto; Y. Otsuka; T. Hamada; A. Imaizumi; Y. Nonaka; T. Fuwa; T. Teramoto; H. Kakeya; H. Wada; K. Hasegawa
Biological and Pharmaceutical Bulletin   36(11) 1708-1714   2013   [Refereed]
ONO YUJI, HATTORI AKIRA, KAKEYA HIDEAKI
日本臨床   70 723-727   Nov 2012
[C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy].
Y. Ohno; A. Hattori; H. Kakeya
Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 8 723-727   Nov 2012   [Refereed]
ISHIKAWA FUMIHIRO, ARAKI MICHIHIRO, KAKEYA HIDEAKI
ファルマシア   48(7) 658-662   Jul 2012
Clinical application of "curcumin", a multi-functional substance.
Shimatsu, A. et al.
Anti-Aging Med. (in press)      2012   [Refereed]
S. Kishimoto; Y. Tsunematsu; S. Nishimura; Y. Hayashi; A. Hattori; H. Kakeya
Tetrahedron   68(27-28) 5572-5578   2012   [Refereed]
Y. Sunagawa; H. Wada; H. Suzuki; H. Sasaki; A. Imaizumi; H. Fukuda; T. Hashimoto; Y. Katanasaka; A. Shimatsu; T. Kimura; H. Kakeya; M. Fujita; K. Hasegawa; T. Morimoto
Biological and Pharmaceutical Bulletin   35(2) 139-144   2012   [Refereed]
Y. Ohno; A. Hattori; M. Ueda; S. Kageyama; T. Yoshiki; H. Kakeya
FEBS Journal   278(21) 4088-4099   Nov 2011   [Refereed]
MORIMOTO TATSUYA, KITA TOORU, FUJITA MASATOSHI, KAKEYA HIDEAKI, HASEGAWA KOJI
臨床薬理の進歩   (32) 1-10   Jun 2011
NISHIMURA SHIN'ICHI, KAKEYA HIDEAKI, YOSHIDA MINORU
化学と生物   49(5) 295-297   May 2011
H. Sasaki; Y. Sunagawa; K. Takahashi; A. Imaizumi; H. Fukuda; T. Hashimoto; H. Wada; Y. Katanasaka; H. Kakeya; M. Fujita; K. Hasegawa; T. Morimoto
Biological and Pharmaceutical Bulletin   34(5) 660-665   May 2011   [Refereed]
Y. Sunagawa; T. Morimoto; H. Wada; T. Takaya; Y. Katanasaka; T. Kawamura; S. Yanagi; A. Marui; R. Sakata; A. Shimatsu; T. Kimura; H. Kakeya; M. Fujita; K. Hasegawa
Circulation Journal   75(9) 2151-2159   2011   [Refereed]
K. Takashima; A. Saitoh; S. Hirose; W. Nakai; Y. Kondo; Y. Takasu; H. Kakeya; H.W. Shin; K. Nakayama
Cell structure and function   36(2) 223-235   2011   [Refereed]
L. Lindqvist; F. Robert; W. Merrick; H. Kakeya; C. Fraser; H. Osada; J. Pelletier
RNA   16(12) 2404-2413   Dec 2010   [Refereed]
Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A, Kawasaki H, Kakeya H, Kobayashi T, Matsunaga S, Yoshida M
Nature chemical biology   6(7) 519-526   Jul 2010   [Refereed]
Y. Hayashi; K. Sankar; H. Ishikawa; Y. Nozawa; K. Mizoue; H. Kakeya
Bioorganic and Medicinal Chemistry Letters   19(14) 3863-3865   Jul 2009   [Refereed]
N. Kato; H. Suzuki; H. Takagi; Y. Asami; H. Kakeya; M. Uramoto; T. Usui; S. Takahashi; Y. Sugimoto; H. Osada
ChemBioChem   10(5) 920-928   Mar 2009   [Refereed]
HASEGAWA KOJI, FUKUDA HIROYUKI, FUJITA MASATOSHI, IKEDA TADASHI, KAKEYA HIDEAKI
政策創薬総合研究研究報告書 平成20年度   272-274   2009
Y. Asami; H. Kakeya; Y. Komi; S. Kojima; K. Nishikawa; K. Beebe; L. Neckers; H. Osada
Cancer Science   99(9) 1853-1858   Sep 2008   [Refereed]
H. Kamiyama; T. Usui; H. Sakurai; M. Shoji; Y. Hayashi; H. Kakeya; H. Osada
Bioscience, Biotechnology and Biochemistry   72(7) 1894-1900   Jul 2008   [Refereed]
KAKEYA HIDEAKI
化学   63(5) 68-69   May 2008
H. Kamiyama; T. Usui; M. Uramoto; H. Takagi; M. Shoji; Y. Hayashi; H. Kakeya; H. Osada
Journal of Antibiotics   61(2) 94-97   2008   [Refereed]
H.D. Jain; C. Zhang; S. Zhou; H. Zhou; J. Ma; X. Liu; X. Liao; A.M. Deveau; C.M. Dieckhaus; M.A. Johnson; K.S. Smith; T.L. Macdonald; H. Kakeya; H. Osada; J.M. Cook
Bioorganic and Medicinal Chemistry   16(8) 4626-4651   2008   [Refereed]
Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR
H. Kamiyama; H. Kakeya; T. Usui; K. Nishikawa; M. Shoji; Y. Hayashi; H. Osada
Oncology Research   17(1) 11-21   2008   [Refereed]
Y. Hayashi; M. Shoji; H. Ishikawa; J. Yamaguchi; T. Tamura; H. Imai; Y. Nishigaya; K. Takabe; H. Kakeya; H. Osada
Angewandte Chemie - International Edition   47(35) 6657-6660   2008   [Refereed]
掛谷 秀昭, 齊藤 安貴子, 長田 裕之
Bio industry   24(7) 48-54   Jul 2007
KAKEYA HIDEAKI
新しい薬物療法の導入とその最適化に関する研究 平成18年度 総括・分担研究報告書   32-33   2007
Discovery of novel bioactive small molecules from microbial metabolites and chemical biology research
H. Kakeya
The Japanese journal of antibiotics   60(3) 181-187   2007   [Refereed]
OSADA HIROYUKI, KAKEYA HIDEAKI
がん分子標的治療   4(1) 24-31   Jan 2006
KAKEYA HIDEAKI
新しい薬物療法の導入とその最適化に関する研究 平成17年度 総括・分担研究報告書   25-26   2006
TOMIKI TAKESHI, TOMIKI TAKESHI, SAITO TAMIO, UEKI MASASHI, KONNO HIDEAKI, ASAOKA TAKEO, SUZUKI RYUICHIRO, URAMOTO MASAKAZU, KAKEYA HIDEAKI, OSADA HIROYUKI
J Comput Aided Chem (Web)   7 157-162 (J-STAGE)   2006
M. Matsuzawa; H. Kakeya; J. Yamaguchi; M. Shoji; R. Onose; H. Osada; Y. Hayashi
Chemistry - An Asian Journal   1(6) 845-851   2006   [Refereed]
H. Taguchi; A. Ohkubo; M. Sekine; K. Seio; H. Kakeya; H. Osada; T. Sasaki
Nucleosides, Nucleotides and Nucleic Acids   25(4-6) 647-654   2006   [Refereed]
K. Kikuchi; H. Kakeya
Nature Chemical Biology   2(8) 392-394   2006   [Refereed]
N. Watanabe; Y. Nishihara; T. Yamaguchi; A. Koito; H. Miyoshi; H. Kakeya; H. Osada
FEBS Letters   580(11) 2598-2602   2006   [Refereed]
I. Shiina; T. Uchimaru; M. Shoji; H. Kakeya; H. Osada; Y. Hayashi
Organic Letters   8(6) 1041-1044   2006   [Refereed]
J. Yamaguchi; M. Toyoshima; M. Shoji; H. Kakeya; H. Osada; Y. Hayashi
Angewandte Chemie - International Edition   45(5) 789-793   2006   [Refereed]
Y. Asami; H. Kakeya; G. Okada; M. Toi; H. Osada
Journal of Antibiotics   59(11) 724-728   2006   [Refereed]
Y. Nagumo; H. Kakeya; M. Shoji; Y. Hayashi; N. Dohmae; H. Osada
Biochemical Journal   387 835-840   May 2005   [Refereed]
KAKEYA HIDEAKI
新しい薬物療法の導入とその最適化に関する研究 平成16年度 総括・分担研究報告書   21-22   2005

Conference Activities & Talks

 
源平麻衣, 砂川陽一, 砂川陽一, 砂川陽一, 船本雅文, 船本雅文, 清水果奈, 清水果奈, 清水聡史, NURMILA Sari, 刀坂泰史, 刀坂泰史, 刀坂泰史, 宮崎雄輔, 宮崎雄輔, 宮崎雄輔, 高橋伸明, 掛谷秀昭, 和田啓道, 長谷川浩二, 森本達也, 森本達也, 森本達也
日本薬学会年会要旨集(CD-ROM)   2018   
杉崎俊文, 高須康明, 服部明, 小嶋聡一, 掛谷秀昭
日本薬学会年会要旨集(CD-ROM)   2018   
今泉厚, 高橋伸明, 光金英宣, 金井雅史, 橋本正, 牧野悠治, 津田孝範, 掛谷秀昭
食品薬学シンポジウム講演要旨集   10 Oct 2017   
下村杜人, 尾崎太郎, 杉山龍介, 西村慎一, 浅水俊平, 掛谷秀昭, 尾仲宏康
日本放線菌学会大会講演要旨集   7 Sep 2017   
掛谷秀昭
日本農芸化学会大会講演要旨集(Web)   5 Mar 2017   

Research Grants & Projects

 
Advanced chemical biology research for establishing system chemotherapy in order to cure multi-factorial diseases; e.g. cancer, immunodeficiency, diabetes, and neuronal diseases.
HCS (high-contents screening) and HTS (high throughput screening) for identifying useful small molecules (bioprobes).
Natural product chemistry for mining novel bioactive small molecules
Biosynthetic studies of natural products and their application to combinatorial biosynthesis