論文

査読有り
2015年3月

Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses

JOURNAL OF RADIATION RESEARCH
  • Masanori Tomita
  • ,
  • Munetoshi Maeda

56
2
開始ページ
205
終了ページ
219
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jrr/rru099
出版者・発行元
OXFORD UNIV PRESS

Elucidating the biological effect of low linear energy transfer (LET), low-dose and/or low-dose-rate ionizing radiation is essential in ensuring radiation safety. Over the past two decades, non-targeted effects, which are not only a direct consequence of radiation-induced initial lesions produced in cellular DNA but also of intra- and inter-cellular communications involving both targeted and non-targeted cells, have been reported and are currently defining a new paradigm in radiation biology. These effects include radiation-induced adaptive response, low-dose hypersensitivity, genomic instability, and radiation-induced bystander response (RIBR). RIBR is generally defined as a cellular response that is induced in non-irradiated cells that receive bystander signals from directly irradiated cells. RIBR could thus play an important biological role in low-dose irradiation conditions. However, this suggestion was mainly based on findings obtained using high-LET charged-particle radiations. The human population (especially the Japanese, who are exposed to lower doses of radon than the world average) is more frequently exposed to low-LET photons (X-rays or gamma-rays) than to high-LET charged-particle radiation on a daily basis. There are currently a growing number of reports describing a distinguishing feature between photon-induced bystander response and high-LET RIBR. In particular, photon-induced bystander response is strongly influenced by irradiation dose, the irradiated region of the targeted cells, and p53 status. The present review focuses on the photon-induced bystander response, and discusses its impact on the low-dose radiation effect.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1093/jrr/rru099
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25361549
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000352490200001&DestApp=WOS_CPL

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