岡野正樹 (Masaki Okano) - マイポータル

基本情報

学位: 農学博士

J-GLOBAL ID: 200901079811029088
researchmap会員ID: 5000072884

研究分野

ライフサイエンス / 分子生物学 /

受賞

1994 - 1995 Research Fellow, Cell Biology, BioScience Center, Nagoya University, Japan 1995 - 2002 Research Fellow in Medicine, Cardiovascular Research Center, Massachusetts General Hospital 1995- 2002 Research Fellow i

論文

Dnmt3a overexpression disrupts skeletal muscle homeostasis, promotes an aging-like phenotype, and reduces metabolic elasticity

Mamoru Oyabu, Yuto Ohira, Mariko Fujita, Kiyoshi Yoshioka, Runa Kawaguchi, Atsushi Kubo, Yukino Hatazawa, Hinako Yukitoshi, Huascar Pedro Ortuste Quiroga, Naoki Horii …

iScience 112144-112144 2025年3月
The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS

Akeo Shinkai, Hideharu Hashimoto, Chikako Shimura, Hiroaki Fujimoto, Kei Fukuda, Naoki Horikoshi, Masaki Okano, Hitoshi Niwa, Erik W Debler, Hitoshi Kurumizaka …

Nucleic Acids Research 52(17) 10194-10219 2024年8月15日
The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases.

Shin-Ichiro Takebayashi, Tyrone Ryba, Kelsey Wimbish, Takuya Hayakawa, Morito Sakaue, Kenji Kuriya, Saori Takahashi, Shin Ogata, Ichiro Hiratani, Katsuzumi Okumura …

Cells 10(2) 2021年1月29日
MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.

Kumi Matsuura, Naoki Tani, Shingo Usuki, Satomi Torikai-Nishikawa, Masaki Okano, Hitoshi Niwa

Experimental cell research 396(1) 112279-112279 2020年9月9日
Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.

Yukino Hatazawa, Yusuke Ono, Yuma Hirose, Sayaka Kanai, Nobuharu L Fujii, Shuichi Machida, Ichizo Nishino, Takahiko Shimizu, Masaki Okano, Yasutomi Kamei …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32(3) 1452-1467 2018年3月査読有り
Developmental Epigenetic Modification Regulates Stochastic Expression of Clustered Protocadherin Genes, Generating Single Neuron Diversity

Shunsuke Toyoda, Masahumi Kawaguchi, Toshihiro Kobayashi, Etsuko Tarusawa, Tomoko Toyama, Masaki Okano, Masaaki Oda, Hiromitsu Nakauchi, Yumiko Yoshimura, Makoto Sanbo …

NEURON 82(1) 94-108 2014年4月査読有り
PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells

Naoki Okashita, Yuichi Kumaki, Kuniaki Ebi, Miyuki Nishi, Yoshinori Okamoto, Megumi Nakayama, Shota Hashimoto, Tomohumi Nakamura, Kaoru Sugasawa, Nakao Kojima …

DEVELOPMENT 141(2) 269-280 2014年1月査読有り
DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

Masaaki Oda, Yuichi Kumaki, Masaki Shigeta, Lars Martin Jakt, Chisa Matsuoka, Akiko Yamagiwa, Hitoshi Niwa, Masaki Okano

PLOS GENETICS 9(6) 2013年6月査読有り
DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

Masaaki Oda, Yuichi Kumaki, Masaki Shigeta, Lars Martin Jakt, Chisa Matsuoka, Akiko Yamagiwa, Hitoshi Niwa, Masaki Okano

PLoS Genetics 9(6) e1003574 2013年6月査読有り
Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver

Tatsuya Ehara, Yasutomi Kamei, Mayumi Takahashi, Xunmei Yuan, Sayaka Kanai, Erina Tamura, Miyako Tanaka, Tomomi Yamazaki, Shinji Miura, Osamu Ezaki …

DIABETES 61(10) 2442-2450 2012年10月査読有り
Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells

Musashi Kubiura, Masaki Okano, Hiroshi Kimura, Fumihiko Kawamura, Masako Tada

CHROMOSOME RESEARCH 20(7) 837-848 2012年10月査読有り
DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

Morito Sakaue, Hiroshi Ohta, Yuichi Kumaki, Masaaki Oda, Yuko Sakaide, Chisa Matsuoka, Akiko Yamagiwa, Hitoshi Niwa, Teruhiko Wakayama, Masaki Okano

CURRENT BIOLOGY 20(16) 1452-1457 2010年8月査読有り
Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation

Masahiro Kaneda, Ryutaro Hirasawa, Hatsune Chiba, Masaki Okano, En Li, Hiroyuki Sasaki

GENES TO CELLS 15(3) 169-179 2010年3月査読有り
Increased Expression of DNA Methyltransferase 3a in Obese Adipose Tissue: Studies With Transgenic Mice

Yasutomi Kamei, Takayoshi Suganami, Tatsuya Ehara, Sayaka Kanai, Koji Hayashi, Yuji Yamamoto, Shinji Miura, Osamu Ezaki, Masaki Okano, Yoshihiro Ogawa

OBESITY 18(2) 314-321 2010年2月査読有り
Abnormal DNA Methyltransferase Expression in Mouse Germline Stem Cells Results in Spermatogenic Defects

Seiji Takashima, Masanori Takehashi, Jiyoung Lee, Shinichiro Chuma, Masaki Okano, Kenichiro Hata, Isao Suetake, Norio Nakatsuji, Hiroyuki Miyoshi, Shoji Tajima …

BIOLOGY OF REPRODUCTION 81(1) 155-164 2009年7月査読有り
QUMA: quantification tool for methylation analysis

Yuichi Kumaki, Masaaki Oda, Masaki Okano

NUCLEIC ACIDS RESEARCH 36(Web Server issue) W170-W175 2008年7月査読有り
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

Mitsuhiro Endoh, Takaho A. Endo, Tamie Endoh, Yu-ichi Fujimura, Osamu Ohara, Tetsuro Toyoda, Arie P. Otte, Masaki Okano, Neil Brockdorff, Miguel Vidal …

DEVELOPMENT 135(8) 1513-1524 2008年4月査読有り
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions

Shin-ichiro Takebayashi, Takashi Tamura, Chisa Matsuoka, Masaki Okano

MOLECULAR AND CELLULAR BIOLOGY 27(23) 8243-8258 2007年12月査読有り
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Jafar Sharif, Masahiro Muto, Shin-ichiro Takebayashi, Isao Suetake, Akihiro Iwamatsu, Takaho A. Endo, Jun Shinga, Yoko Mizutani-Koseki, Tetsuro Toyoda, Kunihiro Okamura …

NATURE 450(7171) 908-U25 2007年12月査読有り
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse

Yuzuru Kato, Masahiro Kaneda, Kenichiro Hata, Kenji Kumaki, Mizue Hisano, Yuji Kohara, Masaki Okano, En Li, Masami Nozaki, Hiroyuki Sasaki

HUMAN MOLECULAR GENETICS 16(19) 2272-2280 2007年10月査読有り

もっとみる

MISC

Selective 5hmC conversion in H3K9me3-negative chromosomal regions in mouse ES cells and human somatic cells

Musashi Kubiura, Masaki Okano, Hiroshi Kimura, Mitsuo Osimura, Masako Tada

GENES & GENETIC SYSTEMS 87(6) 413-413 2012年12月
Role of DNA methylation in the regulation of lipogenic gene expression in the mouse neonatal liver

Yasutomi Kamei, Tatsuya Ehara, Mayumi Takahashi, Xunmei Yuan, Sayaka Kanai, Erina Tamura, Miyako Tanaka, Tomomi Yamazaki, Osamu Ezaki, Takayoshi Suganami …

FASEB JOURNAL 26 2012年4月
Relationship between DNA methylation and gene expression in the protocadherin gene cluster

Shunsuke Toyoda, Masahumi Kawaguchi, Tomoko Toyama, Masaki Okano, Masaaki Oda, Takeshi Yagi

NEUROSCIENCE RESEARCH 68 E352-E352 2010年
The regulation of DNA methylation pattern in the Pcdh-alpha gene cluster during development

Shunsuke Toyoda, Masahumi Kawaguchi, Tomoko Toyama, Masaki Okano, Masaaki Oda, Takeshi Yagi

NEUROSCIENCE RESEARCH 65 S151-S151 2009年
[Regulatory role of DNA methylation during early mouse embryogenesis].

Oda M, Okano M

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 52(16 Suppl) 2183-2188 2007年12月査読有り
[DNA methylation during mouse early embryogenesis].

Oda M, Okano M

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51(14 Suppl) 2027-2034 2006年11月査読有り
Dnmt1/Dnmt3a/Dnmt3bトリプルノックアウトES細胞の解析

津村明子, 早川智博, 熊木勇一, 竹林慎一郎, 阪上守人, 松岡智沙, 下遠野邦忠, 石川冬木, LI En, 上田泰己 …

日本分子生物学会年会講演要旨集 28th 205 2005年11月25日
DNAメチル化酵素Dnmt3bのマウス発生における役割:ICF症候群のマウスモデル

上田佳秀, 岡野正樹, 千葉勉, LI E

日本分子生物学会年会プログラム・講演要旨集 27th 466 2004年11月25日
Genetic analyses of DNA methyltransferase genes in mouse model system

M Okano, E Li

JOURNAL OF NUTRITION 132(8) 2462S-2465S 2002年8月
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation

JE Dodge, BH Ramsahoye, ZG Wo, M Okano, E Li

GENE 289(1-2) 41-48 2002年5月
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

K Hata, M Okano, H Lei, E Li

DEVELOPMENT 129(8) 1983-1993 2002年4月

所属学協会

共同研究・競争的資金等の研究課題

DNAメチル化の制御機構と機能の研究

1995年
Function and regulation of DNA methylation

1995年

岡野正樹

基本情報

研究分野

受賞

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧