HASHIMOTO Tadafumi

J-GLOBAL         Last updated: Sep 27, 2019 at 16:35
 
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Name
HASHIMOTO Tadafumi
Affiliation
The University of Tokyo
Section
Graduate School of Pharmaceutical Sciences, Department of Pharmaceutical Technology

Research Areas

 
 

Published Papers

 
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies.
Sangeun Park, Sei-Kyoung Park, Naruaki Watanabe, Tadafumi Hashimoto, Takeshi Iwatsubo, Tatyana A. Shelkovnikova, Susan W Liebman
PLoS Genetics   15(8) e1008308   Aug 2019   [Refereed]
Characterization of the unique in vitro effects of unsaturated fatty acids on the formation of amyloid  fibrils.
Miki Eto, Tadafumi Hashimoto, Takao Shimizu, Takeshi Iwatsubo
PLoS ONE   14(7) E0219465   Jul 2019   [Refereed]
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease.
Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Molecular Neurodegeneration   143(1) 15   Apr 2019   [Refereed]
Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight.
Taro Bannai, Tatsuo Mano, Xigui Chen, Gaku Ohtomo, Ryo Ohtomo, Takeyuki Tsuchida, Kagari Koshi-Mano, Tadafumi Hashimoto, Hitoshi Okazawa, Takeshi Iwatsubo, Shoji Tsuji, Tatsushi Toda, and Atsushi Iwata
Scientific Reports   9(1) 2827   Feb 2019   [Refereed]
Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplication and missense mutations in APP gene, Down Syndrome and sporadic Alzheimer’s disease.
David MA Mann, Yvonne S Davidson, Andrew C Robinson, Nancy Allen, Tadafumi Hashimoto, Anna Richardson, Matthew Jones, Julie S Snowden, Neil Pendleton, Marie-Claude Potter, Annie Laquerrière, Vee Prasher, Takeshi Iwatsubo, Andre Strydom
Acta Neuropathologica   136(4) 569-587   May 2018   [Refereed]
Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T.
Human Molecular Genetics   27(8) 1353-1365   Apr 2018   [Refereed]
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.
Proceedings of the National Academy of Science of the USA   114(45) E9645-E9654   Nov 2017   [Refereed]
Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.
Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ
Molecular Neurodegeneration   12(1) 27   Mar 2017   [Refereed]
Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T
The Journal of Biological Chemistry   291(45) 23464-23476   Nov 2016   [Refereed]
Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T
The Journal of Biological Chemistry   290(24) 15163-15174   Jun 2015   [Refereed]
Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T
Cell reports   11(6) 859-865   May 2015   [Refereed]
Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA
Molecular neurodegeneration   10 20   Apr 2015   [Refereed]
Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT
PLoS One   9(2) e9901   Feb 2014   [Refereed]
Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience   34(4) 1370-1379   Jan 2014   [Refereed]
Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T
Human molecular genetics   22(22) 4474-4484   Nov 2013   [Refereed]
Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT
Science translational medicine   5(212) 212ra161   Nov 2013   [Refereed]
Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   27(8) 3239-3248   Aug 2013   [Refereed]
Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O
Neurobiology of disease   50 127-134   Feb 2013   [Refereed]
Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D
Scientific reports   3 1823   2013   [Refereed]
Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT
The American journal of pathology   181(4) 1426-1435   Oct 2012   [Refereed]
Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT
The Journal of neuroscience : the official journal of the Society for Neuroscience   32(43) 15181-15192   Oct 2012   [Refereed]
Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL
Brain : a journal of neurology   135(Pt 7) 2155-2168   Jul 2012   [Refereed]
Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT
The Journal of neuroscience : the official journal of the Society for Neuroscience   32(15) 5298-5309   Apr 2012   [Refereed]
Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong STC and Degterev A
The Journal of Biological Chemistry   287(12) 8714-8723   Mar 2012   [Refereed]
Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT
The Journal of neuroscience : the official journal of the Society for Neuroscience   32(9) 3176-3192   Feb 2012   [Refereed]
DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T.
Neurobiology of Disease   45(1) 425-437   Jan 2012   [Refereed]
Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T.
Journal of Neurochemistry   118(3) 407-415   Aug 2011   [Refereed]
Hashimoto T, Adams KW, Fan Z, McLean PJ, Hyman BT
The Journal of biological chemistry   286(31) 27081-27091   Aug 2011   [Refereed]
DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T.
Journal of Neuropathology and Experimental Neurology   70(5) 360-376   Jan 2011   [Refereed]
Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   25(1) 326-336   Jan 2011   [Refereed]
Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT
PloS one   6(1) e14586   Jan 2011   [Refereed]
Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O
Nature communications   1 130   Nov 2010   [Refereed]
Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT
The Journal of neuroscience : the official journal of the Society for Neuroscience   30(7) 2636-2649   Feb 2010   [Refereed]
Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience   29(36) 11393-11398   Sep 2009   [Refereed]
Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL
Proceedings of the National Academy of Sciences of the United States of America   106(10) 4012-4017   Mar 2009   [Refereed]
Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T
The Journal of biological chemistry   283(50) 34554-34562   Dec 2008   [Refereed]
Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T.
Neurochemistry International   52(6) 956-961   May 2008   [Refereed]
Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K
Journal of Biochemistry   143(4) 475-486   Apr 2008   [Refereed]
Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T.
Analytical Chemistry   79(13) 4887-4891   Jul 2007   [Refereed]
Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T
The Journal of biological chemistry   282(7) 4916-4923   Feb 2007   [Refereed]
Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T.
Pharmaceutical Research   23(7) 1407-1416   Jul 2006   [Refereed]
Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T
The Journal of biological chemistry   280(9) 8596-8605   Mar 2005   [Refereed]
Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K.
Journal of Neurology, Neurosurgery, and Psychiatry   75(7) 1039-1042   Jul 2004   [Refereed]
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T
The American journal of pathology   165(1) 273-281   Jul 2004   [Refereed]
Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.
Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J.
Journal of Neuropathology and Experimental Neurology   62(11) 1108-1117   Nov 2003   [Refereed]
Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T
The EMBO journal   21(7) 1524-1534   Apr 2002   [Refereed]
Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, Verkkoniemi A, Kalimo H, Somer M, Paetau A, Martin JJ, Van Broeckhoven C, Golde T, Hardy J, Haltia M, Revesz T.
Annals of Neurology   48(5) 806-808   Nov 2000   [Refereed]
Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T.
The Journal of Biological Chemistry   273(33) 21153-21160   Aug 1998   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(研究活動スタート支援)
Project Year: 2012 - 2013    Investigator(s): Tadafumi HASHIMOTO
To elucidate the mechanism of the metabolism of amyloid beta peptide (Abeta) oligomers in the brain, we have developed in vivo microdialysis technique using a 1,000 kDa cut-off microdialysis probe. Using this techqnique, we identified that the cle...