EGUSA Hiroshi

J-GLOBAL         Last updated: Nov 14, 2018 at 14:20
EGUSA Hiroshi
Tohoku University
Graduate School of Dentistry
Job title
DDS, PhD(Hiroshima University)
Other affiliation
Tohoku University Hospital

Research Areas


Academic & Professional Experience

Apr 2018
Director, Liaison Center for Innovative Dentistry Director, Tohoku University Graduate School of Dentistry
Apr 2018
Vice-Director, Tohoku University Hospital
Apr 2014
Professor and Chair, Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry
Jun 2002
May 2004
Visiting Scholar (Resident Postdoctoral Research Fellow), University of California, Los Angels (UCLA), The Jane and Jerry Weintraub Center for Reconstructive Biotechnology
Apr 2002
Mar 2004
Japanese Government Special Postdoctoral Research Fellow, Japan Society for the Promotion of Science (JSPS)
Jan 1999
Jul 1999
Technical Assistant, University of Hong Kong, Department of Oral Microbiology


Apr 1998
Mar 2002
PhD: Division of Dental Science, Graduate School, Hiroshima University
Apr 1992
Mar 1998
DDS: Faculty of Dentistry, Hiroshima University

Awards & Honors

Aug 2013
Distinguished Achievement and Contributions Award, Osaka University
Jun 2012
Distinguished Scientist Award (Young Investigator Award), International Association for Dental Research (IADR)
Aug 2011
Distinguished Achievement and Contributions Award for Research, Osaka University
Award for Distinguished Research in the Oral Sciences
2010 Best Paper Award
Best Oral Presentation Award (1st Prize)
Distinguished Faculty Award for Research (Yumikura Award)
Outstanding Poster Presentation Award
Best Poster Presentation Award: The 6th Biennial Meeting of Asian Academy of Prosthodontics
Outstanding Oral Presentation Award
Winner, Arthur R. Frechette Research Award Competition in Prosthodontics,
Winner, Arthur R. Frechette Research Award Competition in Prosthodontics,
1st Place Winner, Edward H. Hatton Awards Competition (Senior Category)
Unilever Division Travel Award (Finalist of the Japanese Association for Dental Research)
1st Place Winner, Edward H. Hatton Awards Competition (Senior Category)
Unilever Division Travel Award (Finalist of the Japanese Association for Dental Research)

Published Papers

A thick frame decreases the fracture toughness of veneering ceramics used for zirconia-based all-ceramic restorations
Yamauchi S, Miura S, Kasahara S, Sun J, Egusa H.
J Prosthodont Res   in press    2019   [Refereed]
A novel pathway for the photooxidation of catechin in relation to its prooxidative activity
Shishido S, Miyano R, Nakashima T, Matsuo H, Iwatsuki M, Nakamura K, Kanno T, Egusa H, Niwano Y
Sci Rep   8(1) 12888   2018   [Refereed]
Clinical evaluation of zirconia-based all-ceramic single crowns: an up to 12-year retrospective cohort study
Miura S, Kasahara S, Yamauchi S, Okuyama Y, Izumida A, Aida J, Egusa H
Clin Oral Investig   22(2) 697-706   2018   [Refereed]
Miura S, Kasahara S, Yamauchi S, Egusa H
Eur J Oral Sci   126(2) 159-165   2018   [Refereed]
Kamano Y, Watanabe J, Iida T, Kondo T, Okawa H, Yatani H, Saeki M, Egusa H
Biochem Biophys Res Commun   496(1) 83-88   2018   [Refereed]
Nowwarote N, Chanjavanakul P, Kongdecha P, Clayhan P, Egusa H, Pavasant P, Osathanon T
Arch Oral Biol   88 24-33   2018   [Refereed]
RNA sequencing data of Notch ligand treated human dental pulp cells
Manokawinchoke J, Nattasit P, Thongngam T, Pavasant P, Tompkins KA, Egusa H, Osathanon T
Data Brief   17 407-413   2018   [Refereed]
Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns
Ankyu S, Nakamura K, Harada A, Inagaki R, Kastuda Y, Kanno T, Niwano Y, Örtengren U, Egusa H
J Mech Behav Biomed Mater   86(89) 97   2018   [Refereed]
Prolonged release of bone morphogenetic protein-2 in vivo by gene transfection with DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds
Tenkumo T, Vanegas Sáenz JR, Nakamura K, Shimizu Y, Sokolova V, Epple M, Kamano Y, Egusa H, Sugaya T, Sasaki K
Mater Sci Eng C Mater Biol Appl   92 172-183   2018   [Refereed]
The effects of platelet-derived growth factor-BB on bone marrow stromal cell-mediated vascularized bone regeneration
Zhang M, Yu W, Niibe K, Zhang W, Egusa H, Jiang X
Stem Cells Int   Article ID 3272098    2018   [Refereed]
A possible risk of CAD/CAM-produced composite resin premolar crowns on a removable partial denture abutment tooth: A 3-year retrospective cohort study
Miura S, Kasahara S, Yamauchi S, Katsuda Y, Harada A, Aida J, Egusa H
J Prosthodont Res   in press    2018   [Refereed]
Yamada M, Egusa H
J Prosthodont Res   62(2) 152-161   2018   [Refereed]
Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress
Watanabe J, Yamada M, Niibe K, Maolin Z, Kondo T, Ishibashi M, Egusa H
Biomaterials   185 25-38   2018   [Refereed]
Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation
Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Örtengren U, Kanno T, Niwano Y, Egusa H.
PLoS One   13(9) e0203849   2018   [Refereed]
Three-dimensional finite element analysis of zirconia all-ceramic cantilevered fixed partial dentures with different framework designs
Miura S, Kasahara S, Yamauchi S, Egusa H
Eur J Oral Sci   125(3) 208-214   2017   [Refereed]
Activation of osteoblastic function on titanium surface with titanium-doped hydroxyapatite nano-particle coating: an in vitro study
Nakazawa M, Yamada M, Wakamura M, Egusa H
Int J Oral Maxillofac Implants   32(4) 779-791   2017   [Refereed]
Osathanon T, Manokawinchoke J, Egusa H, Pavasant P
J Oral Sci   59(3) 405-413   2017   [Refereed]
Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells
Manokawinchoke J, Nattasit P, Thongngam T, Pavasant P, Tompkins KA, Egusa H, Osathanon T
Sci Rep   7(1) 10124   2017   [Refereed]
Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles
Vanegas Sáenz JR, Tenkumo T, Kamano Y, Egusa H, Sasaki K
PLoS One   12(11) e0188347   2017   [Refereed]
Niibe K, Suehiro F, Oshima M, Nishimura M, Kuboki T, Egusa H
J Prosthodont Res   61(1) 3-5   2017   [Refereed]
Niibe K, Zhang M, Nakazawa K, Morikawa S, Nakagawa T, Matsuzaki Y, Egusa H
Jpn Dent Sci Rev   53(2) 25-33   2017   [Refereed]
Progress of the Journal of Prosthodontic Research under the four-year action plan
Egusa H
J Prosthodont Res   61(3) 231-232   2017   [Refereed][Invited]
Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model
Takagi R, Ishimaru J, Sugawara A, Toyoshima K, Ishida K, Ogawa M, Sakakibara K, Asakawa K, Kashiwakura A, Oshima M, Minamide R, Sato A, Yoshitake T, Takeda A, Egusa H, Tsuji T
Science Advances   2 e1500887   Apr 2016   [Refereed]
Okawa H, Kayashima H, Sasaki JI, Miura J, Kamano Y, Kosaka Y, Imazato S, Yatani H, Matsumoto T, Egusa H
Stem Cells Int   Article ID 6240794   Mar 2016   [Refereed]
Egusa H
Journal of prosthodontic research   60(1) 1-2   Jan 2016   [Refereed][Invited]
Yu G, Okawa H, Okita K, Kamano Y, Wang F, Saeki M, Yatani H, Egusa H
J Dent Res   95(1) 110-118   Jan 2016   [Refereed]
Nakamura K, Katsuda Y, Ankyu S, Harada A, Tenkumo T, Kanno T, Niwano Y, Egusa H, Milleding P, Örtengren U
European journal of oral sciences   in press   2016   [Refereed]
Akiba Y, Mizuta A, Kakihara Y, Nakata J, Nihara J, Saito I, Egusa H, Saeki M
Biochem Biophys Rep   5 253-258   2016   [Refereed]
Manokawinchoke J, Osathanon T, Egusa H, Pavasant P
Tissue Eng Regen Med   in press   2016   [Refereed]
Ankyu S, Nakamura K, Harada A, Hong G, KannoT, Niwano Y, Örtengren U, Egusa H
Eur J Oral Sci   124(4) 387-395   2016   [Refereed]
Sato H, Niwano Y, Nakamura K, Mokudai T, Ikai H, Kanno T, Egusa H
J Toxicol Sci   41(6) 793-799   2016   [Refereed]
Harada A, Nakamura K, Kanno T, Inagaki R, Örtengren U, Niwano Y, Sasaki K, Egusa H
European journal of oral sciences   123(2) 122-129   Apr 2015   [Refereed]
Takeichi T, Miura S, Kasahara S, Egusa H, Hara M, Sato T, Yoshinari M, Odatsu T, Watanabe I, Sawase T
Journal of prosthodontic research   59(2) 81-83   Apr 2015   [Refereed]
Toki T, Nakamura K, Kurauchi M, Kanno T, Katsuda Y, Ikai H, Hayashi E, Egusa H, Sasaki K, Niwano Y
Journal of bioscience and bioengineering   119(3) 358-362   Mar 2015   [Refereed]
Shiomi A, Izumi K, Uenoyama A, Saito T, Saito N, Ohnuki H, Kato H, Kanatani M, Nomura S, Egusa H, Maeda T
J Oral Rehabil   42(3) 192-201   Mar 2015   [Refereed]
Watamoto T, Egusa H, Sawase T, Yatani H
Frontiers in microbiology   6 1453   2015   [Refereed]
Wang F, Okawa H, Kamano Y, Niibe K, Kayashima H, Osathanon T, Pavasant P, Saeki M, Yatani H, Egusa H
PloS one   10(12) e0145677   2015   [Refereed]
Katsuda Y, Niwano Y, Nakashima T, Mokudai T, Nakamura K, Oizumi S, Kanno T, Kanetaka H, Egusa H
PloS one   10(8) e0134704   2015   [Refereed]
Ono H, Obana A, Usami Y, Sakai M, Nohara K, Egusa H, Sakai T
BioMed research international   2015 293570   2015   [Refereed]
Matsumoto T, Egusa H, Kato K, Tsuji T
J Oral Biosci   57(2) 80-85   2015   [Refereed][Invited]
Saeki M, Egusa H
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   144(6) 277-280   Dec 2014   [Refereed]
Nagao S, Goto T, Kataoka S, Toyono T, Joujima T, Egusa H, Yatani H, Kobayashi S, Maki K
Neuropeptides   48(6) 399-406   Dec 2014   [Refereed]
Kurauchi M, Niwano Y, Shirato M, Kanno T, Nakamura K, Egusa H, Sasaki K
PloS one   9(11) e113403   Nov 2014   [Refereed]
Tsuruya M, Niwano Y, Nakamura K, Kanno T, Nakashima T, Egusa H, Sasaki K
Applied biochemistry and biotechnology   174(6) 2223-2235   Nov 2014   [Refereed]
Egusa H
Journal of Prosthodontic Research   58(4) 191-192   Oct 2014   [Refereed]
Egusa H, Kayashima H, Miura J, Uraguchi S, Wang F, Okawa H, Sasaki J-I, Saeki M, Matsumoto Y, Yatani H
Stem Cells Dev   23(18) 2156-2169   Sep 2014   [Refereed]
Ko N, Mine A, Egusa H, Shimazu T, Ko R, Nakano T, Yatani H
J Prosthodont   23(6) 501-503   Aug 2014   [Refereed]
Arakaki M, Egusa H, Otsu K, Saito I, Miura T, Harada H
Journal of Oral Biosciences   55(4) 191-199   Nov 2013   [Refereed][Invited]
Watamoto T, Egusa H, Sawase T, Yatani H
International Journal of Prosthodontics   26(6) 541-544   Nov 2013   [Refereed]
Kamano Y, Saeki M, Egusa H, Kakihara Y, Houry WA, Yatani H, Kamisaki Y
FEBS Letter   587(20) 3303-3308   Oct 2013   [Refereed]


Gene delivery and expression systems in induced pluripotent stem cells
Zhang M, Niibe K, Kondo T, Kamano Y, Saeki M, Egusa H
Interface Oral Health Science 2016, Springer   121-133   2017   [Invited]
Yu G, Kamano Y, Wang F, Okawa H, Yatani H, Egusa H
Interface Oral health Science 2014, Eds: Sasaki K, Suzuki O, Takahashi N, Springer   2014 145-159   2015   [Invited]
Egusa H
Interface Oral health Science 2011, Eds: Sasaki K, Suzuki O, Takahashi N, Springer   2011 9-13   Mar 2012   [Invited]
In vitro engineering of patterned three-dimensional tissue using fibrin gel
Journal of Osaka Univeristy Dental Society   55(2): 83-89    2011
Possible Application of Gingiva-Derived iPS Cells in Dentistry
Nippon Dental Review   71 (7):9-11    2011
Recent advances in iPS cell research
Journal of Osaka Univeristy Dental Society   55(1): 11-29    2010
Impact of iPS cell research on dentistry -Potential of gingiva as an iPS cell source-
Dental Diamond   35 (514):60-64    2010
Current Developments in Oromaxillofacial Regeneration. In Cutting-Edge Biodentistry (Ed. Yoneda T)
Osaka University Press      2008
Cementation and trial cement. In Word Book for Esthetic and Implant Dentistry
Practice in Prosthodontics, Sp. Iss   92-93    2008
Disinfection of dental impressions
Dental Outlook   112 (2):341-347    2008

Books etc

Handbook of immunohistochemistry and in situ hybridization of human carcinomas ~Molecular genetics: Liver and Pancreatic Carcinomas~ Vol. 3.
Zhou X, Egusa H, Cole SW, Nishimura I, Wong DTW (Part:Contributor, Methodology of microarray data analysis)
Elsevier Academic Press   2005   
Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression in Candida albicans-Infected Human Gingival Epithelial Cells. In Interface Oral Health Science: International Congress Series No. 1284
Elsevier B.V.   2005   
Textbook of preclinical training in fixed prothodontics
Osaka University Press   2010   

Conference Activities & Talks

In vitro bone tissue fabrication by using iPS cells [Invited]
EGUSA Hiroshi
The 96th IADR General Session   26 Jul 2018   
Emerging approaches for “regenerative prosthodontics” [Invited]
EGUSA Hiroshi
20 Oct 2017   
iPS cell-based strategies in bone tissue engineering
EGUSA Hiroshi
The 2nd Annual Academic Conference of Society of Dental Research Administration, CSA   25 Aug 2017   
iPS cell-based strategies in bone tissue engineering [Invited]
EGUSA Hiroshi
The 6th International Symposium for Interface Oral Health Science   19 Jan 2016   
iPS cells: What they are and what they can contribute to the field of dentistry [Invited]
EGUSA Hiroshi
Chulalongkorn-Tohoku Joint Symposium in Dental Science 2015   9 Dec 2015   

Research Grants & Projects

Differentiation mechanism of adult stem cell


特許米国(第8222216号) : Mesenchymal cell proliferation promoter and skeletal system biomaterial
EGUSA Hiroshi